1-(hept-1-en-yl)pyrrolidine | 39995-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(hept-1-en-yl)pyrrolidine
• 英文别名: 1-hept-1-en-ξ-yl-pyrrolidine；1-Hept-1-en-ξ-yl-pyrrolidin；1-Hept-1-enylpyrrolidine
• CAS: 39995-02-3
• 化学式: C₁₁H₂₁N
• 分子量: 167.294
• InChiKey: INKLZJSYMQAVCB-UHFFFAOYSA-N

物化性质

• 沸点：
  110 °C(Press: 12 Torr)
• 密度：
  0.920±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(hept-1-en-yl)pyrrolidine 在 lithium aluminium tetrahydride 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 41.0h， 生成
  参考文献：
  名称：

  长春花生物碱及相关化合物LXXXV †的合成。azepino [3,4- b ]吲哚的研究

  摘要：

  描述了从吲哚-3-丙胺1开始合成一些新的吡啶并[1'，2'：1,2] azepino [3,4- b ]吲哚。讨论了立体化学和观察到的副反应。

  DOI：

  10.1002/jhet.5570340430
• 作为产物：
  描述：

  四氢吡咯 、 庚醛 在 potassium carbonate 作用下， 生成 1-(hept-1-en-yl)pyrrolidine
  参考文献：
  名称：

  Method for the production of alpha-substituted organic carbonyl compounds

  摘要：

  公开号：

  US02773087A1

文献信息

• A New Stereoselective Cyclopropane Synthesis
  作者：András Dancsó、Mária Kajtár-Peredy、Csaba Szántay、György Kalaus

  DOI：10.1055/s-1985-31443

  日期：——

  2-Alkyl-2-formyl-cyclopropane-1-carbonitriles 4, 5 and 4-formyl-2-haloalkanenitriles 3 were prepared from aliphatic enamines 1 and 2-haloacrylonitriles 2. Both stereoisomers of the cyclopropane derivatives were obtained stereoselectively using appropriate reaction conditions.

  由脂肪族烯胺1和2-卤代丙烯腈2制备2-烷基-2-甲酰基-环丙烷-1-甲腈4、5和4-甲酰基-2-卤代烷腈3。使用适当的反应条件立体选择性地获得环丙烷衍生物的两种立体异构体。
• Rhodium exchanged ETS-10 and ETS-4: Efficient heterogeneous catalyst for hydroaminomethylation
  作者：N. Sudheesh、Ram S. Shukla

  DOI：10.1016/j.apcata.2014.01.002

  日期：2014.3

  Rhodium exchanged titanosilicates (ETS-10 and ETS-4) were synthesized and found to be efficient and stable catalysts for hydroaminomethylation reaction. The catalyst was highly active and selective towards amine product within lower reaction time of 4 h. 1-Hexene and pyrrolidine were taken as representative substrates for parametric variations using Rh-ETS-10. The increase in pyrrolidine ratio gave some significant information showing a decrease in conversion with increased selectivity. The reason may be the competition between pyrrolidine and 1-hexene for coordination sites in rhodium and which prevents the beta-hydride elimination. The ratios of H-2 and CO have influenced hydroaminomethylation and the best performance was in the CO: H-2 ratio of 1:4 under the studied conditions. The initial rate of formation of amine was double than that of isomerization of 1-hexene. The Rh cluster like complex was formed on treating the catalyst with syn gas. A homogenous-heterogeneous dual nature of Rh was found during hydroaminomethylation. The catalyst was effectively recycled for three times without much loss in its activity and selectivity. (C) 2014 Elsevier B.V. All rights reserved.