isophthalic acid bis(trimethylsilyl)ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: isophthalic acid bis(trimethylsilyl)ester
• 英文别名: bis(trimethylsilyl) 1,3-benzenediacetate；Bis(trimethylsilyl) isophthalate；bis(trimethylsilyl) benzene-1,3-dicarboxylate
• 化学式: C₁₄H₂₂O₄Si₂
• 分子量: 310.497
• InChiKey: XBYWPSUAELKTET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.67
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  isophthalic acid bis(trimethylsilyl)ester 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 生成 间苯二甲酰氯
  参考文献：
  名称：

  Asymmetric synthesis of phenylbis(glycines)

  摘要：

  (S,S)-alpha,alpha'-Diamino-1,4- and 1,3-benzenediacetic acids and N-Boc- and N-Fmoc-derivatives have been prepared by stereoselective syntheses. The chiral auxiliary (S)-4-benzyl-2-oxazolidinone formed bisimides with benzenediacetyl dichlorides The imides were lithiated at both a-sites to the carbonyl groups and azidated stereoselectively alpha to both carbonyl groups by trisyl azide to provide (S,S)-alpha,alpha'-diazidobenzenediacetic acid derivatives which were reduced to amines by Sn(II) chloride or by hydrogenolysis over Pd. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4020(96)00344-4
• 作为产物：
  描述：

  间苯二甲酸 、 trimethylsilyl 2,2,2-trifluoro-N-(trimethylsilyl)acetimidate 生成 isophthalic acid bis(trimethylsilyl)ester
  参考文献：
  名称：

  GHOLSON, ALEXANDER ROGERS;LOUIS, ROBERT ST.;HILL, HERBERT HENDERSON, J. CHROMATOGR., 408,(1987) 329-334

  摘要：

  DOI：

文献信息

• Silacyclophanones – cyclic organosilicon esters of isophthalic acid
  作者：Sergey V. Basenko、Anastasiya S. Soldatenko

  DOI：10.1007/s10593-018-2239-5

  日期：2018.1

  of previously unknown 16-membered cyclic organosilicon esters of isophthalic acid (silacyclophanones) in 69–77% yields. The reaction of isophthalic ester with 1,3-dichloro-1,3-dimethyl-1,3-divinyldisiloxane gave 14-membered cyclosiloxane ester as the main product, while the reaction of disiloxane with trimethylsilyl ester of phthalic acid produced a 9-membered cyclic ester in 65% yield.

  甲基（有机基）二氯硅烷（MeRSiCl 2，R = Me，CH = CH 2，Ph）与间苯二甲酸三甲基甲硅烷基酯的反应导致形成了以前未知的间苯二甲酸十六碳环有机硅酯（硅环环酮） –77％的收益率。间苯二甲酸酯与1,3-二氯-1,3-二甲基-1,3-二乙烯基二硅氧烷的反应生成了14元环硅氧烷酯为主要产物，而二硅氧烷与邻苯二甲酸三甲基甲硅烷基酯的反应生成了9元环酯产率为65％。
• GHOLSON, ALEXANDER ROGERS;LOUIS, ROBERT ST.;HILL, HERBERT HENDERSON, J. CHROMATOGR., 408,(1987) 329-334
  作者：GHOLSON, ALEXANDER ROGERS、LOUIS, ROBERT ST.、HILL, HERBERT HENDERSON

  DOI：——

  日期：——
• AL-TIMIMI, K. Y.;ALLEN, B. J., ABSTR. PAP. PITTSBURGH CONF. AND EXPO. ANAL. CHEM. AND APPL. SPECTROSC., +
  作者：AL-TIMIMI, K. Y.、ALLEN, B. J.

  DOI：——

  日期：——
• Asymmetric synthesis of phenylbis(glycines)
  作者：Mette Lene Falck-Pedersen、Kjell Undheim

  DOI：10.1016/s0040-4020(96)00344-4

  日期：1996.5

  (S,S)-alpha,alpha'-Diamino-1,4- and 1,3-benzenediacetic acids and N-Boc- and N-Fmoc-derivatives have been prepared by stereoselective syntheses. The chiral auxiliary (S)-4-benzyl-2-oxazolidinone formed bisimides with benzenediacetyl dichlorides The imides were lithiated at both a-sites to the carbonyl groups and azidated stereoselectively alpha to both carbonyl groups by trisyl azide to provide (S,S)-alpha,alpha'-diazidobenzenediacetic acid derivatives which were reduced to amines by Sn(II) chloride or by hydrogenolysis over Pd. Copyright (C) 1996 Elsevier Science Ltd

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