N,N'-L-cystyl-bis-glycine diethyl ester | 33642-58-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-L-cystyl-bis-glycine diethyl ester
• 英文别名: L-Cystin-bis-(aethoxycarbonylmethyl-amid)；N,N'-L-Cystyl-bis-glycin-diaethylester；H-Cys(1)-Gly-OEt.H-Cys(1)-Gly-OEt；ethyl 2-[[(2R)-2-amino-3-[[(2R)-2-amino-3-[(2-ethoxy-2-oxoethyl)amino]-3-oxopropyl]disulfanyl]propanoyl]amino]acetate
• CAS: 33642-58-9
• 化学式: C₁₄H₂₆N₄O₆S₂
• 分子量: 410.516
• InChiKey: ASYXAYBHPLTSBA-UWVGGRQHSA-N

物化性质

• 沸点：
  620.7±55.0 °C(Predicted)
• 密度：
  1.305±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  213
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  N,N'-L-cystyl-bis-glycine diethyl ester 在 barium dihydroxide 作用下， 生成 -L-胱氨酰基二甘氨酸
  参考文献：
  名称：

  679.由脱水N-羧基氨基酸合成简单的肽

  摘要：

  DOI：

  10.1039/jr9500003461
• 作为产物：
  描述：

  N,N'-双(叔丁氧羰基)-L-胱氨酸 在 三乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 N,N'-L-cystyl-bis-glycine diethyl ester
  参考文献：
  名称：

  Thiirancarboxamides 作为木瓜蛋白酶的抑制剂

  摘要：

  合成含有肽键的硫茚甲酸结构单元的衍生物，并针对模型半胱氨酸蛋白酶木瓜蛋白酶进行筛选。该系列中最活跃的表现出与母体化合物相当的二阶失活速率常数。肽部分的插入似乎弥补了在酶活性位点与组氨酸鎓离子相互作用的游离羧酸盐的缺乏。

  DOI：

  10.1002/ardp.200300820

文献信息

• [EN] COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSÉS POUR L'ADMINISTRATION DE GLUTATHION À UNE CIBLE ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
  申请人：UNIV OREGON STATE

  公开号：WO2017214297A1

  公开（公告）日：2017-12-14

  Disclosed herein are embodiments of compounds that can be used to target glutathione to various target sites, such as cells, mitochondria, and other organelles. Also disclosed herein are embodiments of methods for making and using the compounds. In particular disclosed embodiments, the compounds can be used to treat, ameliorate, and/or prevent diseases or conditions associated with low or reduced glutathione levels, as well as other types of diseases/conditions.

  本文披露了可以用于靶向谷胱甘肽到各种目标位点的化合物实施例，例如细胞、线粒体和其他细胞器。本文还披露了制备和使用这些化合物的方法的实施例。特别披露的实施例中，这些化合物可用于治疗、改善和/或预防与低谷胱甘肽水平或减少有关的疾病或症状，以及其他类型的疾病/症状。
• A Magnetic Resonance Imaging Study of Regional Cortical Volumes Following Stereotactic Anterior Cingulotomy
  作者：Scott L. Rauch、Nikos Makris、G. Rees Cosgrove、Hackjin Kim、Edwin H. Cassem、Bruce H. Price、Lee Baer、Cary R. Savage、Verne S. Caviness、Michael A. Jenike、David N. Kennedy

  DOI：10.1017/s1092852900008592

  日期：2001.3

  The purpose of this study was to test the hypothesis that orbitofrontal cortical volume would be reduced following anterior cingulotomy for obsessive-compulsive disorder (OCD). Whole brain cortical parcellation was performed on magnetic resonance imaging (MRI) data from nine patients, before and 9(±6) months following anterior cingulotomy. No significant volumetric reductions were found in the orbitofrontal cortex. Exploratory findings of reduced volume in ventral temporo-fusiform and posterior cingulate regions were consistent with chance differences, in the face of multiple comparisons. Therefore, though the circumscribed lesions of anterior cingulotomy have recently been associated with corresponding volumetric reductions in the caudate nucleus, no comparable volumetric reductions are evident in cortical territories. Taken together, these results are most consistent with a model of cingulo-striatal perturbation as a putative mechanism for the efficacy of this procedure. While limitations in sensitivity may have also contributed to these negative findings, the methods employed have previously proven sufficient to detect cortical volumetric abnormalities in OCD. The current results may reflect a relatively diffuse pattern of cortico-cortical connections involving the neurons at the site of cingulotomy lesions. Future functional neuroimaging studies are warranted to assess possible cortical or subcortical metabolic changes associated with anterior cingulotomy, as well as predictors of treatment response.

  摘要 本研究的目的是验证强迫症（OCD）前部蝶鞍切除术后眶额叶皮质体积会缩小的假设。研究人员对九名患者的磁共振成像（MRI）数据进行了全脑皮质解析，结果显示，在前枕叶切除术前和切除术后9（±6）个月，患者的眶额皮质体积均有所减少。结果发现，眶额皮质的体积没有明显缩小。腹侧颞-纺锤形区和后扣带回区体积缩小的探索性发现与多重比较下的偶然差异一致。因此，虽然前扣带回切除术的环形损伤最近与尾状核相应的体积缩小有关，但在皮质区域并没有明显的可比体积缩小。综合来看，这些结果最符合作为该手术疗效推定机制的脊髓-纹状体扰动模型。虽然灵敏度方面的局限性也可能是导致这些负面结果的原因之一，但之前采用的方法已被证明足以检测出强迫症患者的皮质容积异常。目前的研究结果可能反映了涉及蝶窦切除术病变部位神经元的皮质-皮质连接的相对弥散模式。今后有必要进行功能神经影像学研究，以评估与前部cingulotomy相关的皮质或皮质下代谢变化，以及治疗反应的预测因素。
• COMPOUNDS FOR DELIVERING GLUTATHIONE TO A TARGET AND METHODS OF MAKING AND USING THE SAME
  申请人：Oregon State University

  公开号：US20190106456A1

  公开（公告）日：2019-04-11

  Disclosed herein are embodiments of compounds that can be used to target glutathione to various target sites, such as cells, mitochondria, and other organelles. Also disclosed herein are embodiments of methods for making and using the compounds. In particular disclosed embodiments, the compounds can be used to treat, ameliorate, and/or prevent diseases or conditions associated with low or reduced glutathione levels, as well as other types of diseases/conditions.