1-((E)-5-Benzyloxy-octa-1,7-dienyl)-4-methoxy-benzene | 506417-54-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-((E)-5-Benzyloxy-octa-1,7-dienyl)-4-methoxy-benzene
• 英文别名: 1-methoxy-4-[(1E)-5-phenylmethoxyocta-1,7-dienyl]benzene
• CAS: 506417-54-5
• 化学式: C₂₂H₂₆O₂
• 分子量: 322.447
• InChiKey: MIPVYSVRDLMEOG-JXMROGBWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-((E)-5-Benzyloxy-octa-1,7-dienyl)-4-methoxy-benzene 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷-D2 为溶剂， 以73%的产率得到((cyclohex-3-enyloxy)methyl)benzene
  参考文献：
  名称：

  Relative Rate Profile for Ring-Closing Metathesis of a Series of 1-Substituted 1,7-Octadienes as Promoted by a 4,5-Dihydroimidazol-2-ylidene-Coordinated Ruthenium Catalyst

  摘要：

  GraphicsThis report details the kinetic responses of nine compounds of type 6 to ring-closing metathesis as promoted by 2 to give the identical product 7. The experimental observations have been subjected to Hammett analysis. The rho value for the composite aromatic derivatives (R = p-XC6H4-) differs from that of the aliphatic series, although both are negative because electron-donating groups accelerate the reaction.

  DOI：

  10.1021/ol0272794
• 作为产物：
  描述：

  (4-benzyloxy-hept-6-enyloxy)-tert-butyl-dimethyl-silane 在 正丁基锂 、 四丁基氟化铵 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.25h， 生成 1-((E)-5-Benzyloxy-octa-1,7-dienyl)-4-methoxy-benzene
  参考文献：
  名称：

  Relative Rate Profile for Ring-Closing Metathesis of a Series of 1-Substituted 1,7-Octadienes as Promoted by a 4,5-Dihydroimidazol-2-ylidene-Coordinated Ruthenium Catalyst

  摘要：

  GraphicsThis report details the kinetic responses of nine compounds of type 6 to ring-closing metathesis as promoted by 2 to give the identical product 7. The experimental observations have been subjected to Hammett analysis. The rho value for the composite aromatic derivatives (R = p-XC6H4-) differs from that of the aliphatic series, although both are negative because electron-donating groups accelerate the reaction.

  DOI：

  10.1021/ol0272794

文献信息

• Relative Rate Profile for Ring-Closing Metathesis of a Series of 1-Substituted 1,7-Octadienes as Promoted by a 4,5-Dihydroimidazol-2-ylidene-Coordinated Ruthenium Catalyst
  作者：Xin Guo、Kallol Basu、Jose A. Cabral、Leo A. Paquette

  DOI：10.1021/ol0272794

  日期：2003.3.1

  GraphicsThis report details the kinetic responses of nine compounds of type 6 to ring-closing metathesis as promoted by 2 to give the identical product 7. The experimental observations have been subjected to Hammett analysis. The rho value for the composite aromatic derivatives (R = p-XC6H4-) differs from that of the aliphatic series, although both are negative because electron-donating groups accelerate the reaction.