N-Dodecyl-N,N-bis<2-(methoxycarbonyl)ethyl>amine | 102464-90-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Dodecyl-N,N-bis<2-(methoxycarbonyl)ethyl>amine
• 英文别名: dimethyl 3,3'-(dodecylazanediyl)dipropanoate；dimethyl 3,3'-(dodecylamino)dipropionate；Lauryl di(-β-methoxycarbonylethyl)amin；N-dodecyliminodipropionate dimethyl ester；methyl 3-[dodecyl-(3-methoxy-3-oxopropyl)amino]propanoate
• CAS: 102464-90-4
• 化学式: C₂₀H₃₉NO₄
• 分子量: 357.534
• InChiKey: XEOMMWPLEQDQGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-Dodecyl-N,N-bis<2-(methoxycarbonyl)ethyl>amine 在 盐酸 、 甲醇 、 sodium hydride 作用下， 以 苯 为溶剂， 反应 19.0h， 生成 1-Dodecyl-4-piperidinone
  参考文献：
  名称：

  Catalytic Epoxidation of Alkenes with Oxone

  摘要：

  A practical, general and efficient protocol for the catalytic epoxidation of alkenes has been developed. The in situ generation of reactive dioxiranes capable of epoxidizing a variety of alkenes under biphasic conditions has been accomplished using phase transfer catalysts bearing a carbonyl group. Optimal epoxidation conditions employ 10 mol % of 1-dodecyl-1-methyl-4-oxopiperidinium triflate (8d(+)OTf(-)) in a CH2Cl2/pH 7.5-8.0 biphase using potassium monoperoxosulfate (Oxone) as the oxidant. Optimization of the conditions identified (1) slow addition rate, (2) pH 7.5-8.0, (3) N-dodecyl chain, and (4) the triflate salt as key experimental and structural variables. A selection of nine olefins was successfully oxidized to the corresponding epoxides in 83-96% yield.

  DOI：

  10.1021/jo00110a049
• 作为产物：
  描述：

  十二烷基伯胺 、 丙烯酸甲酯（MA） 以 甲醇 为溶剂， 反应 4.0h， 生成 N-Dodecyl-N,N-bis<2-(methoxycarbonyl)ethyl>amine
  参考文献：
  名称：

  胺类抗氧剂及其制备方法与应用

  摘要：

  本发明公开一种胺类抗氧剂及其制备方法与应用，该胺类抗氧剂具有以下结构：#imgabs0#其中，n为1‑20的整数。该制备方法包括如下步骤：步骤1，正烷基胺与丙烯酸甲酯反应得到式Ⅰ化合物；步骤2，式Ⅰ化合物与二氯亚砜反应生成式Ⅱ化合物；步骤3，式Ⅱ化合物与对苯二胺反应生成式Ⅲ化合物；步骤4，式Ⅲ化合物与β‑萘酚反应生成式Ⅳ胺类抗氧剂。本发明得到的胺类抗氧剂为浅黄色粉末，无味，通过红外光谱和核磁碳谱的表征结果证明该抗氧剂的分子结构与理论结构一致。该方法中未使用价格昂贵的催化剂，反应条件温和，且原料便宜易得，具有很好的经济性。

  公开号：

  CN113527133B

文献信息

• ANTIMICROBIALS FOR PRESERVATION OF HOME AND PERSONAL CARE PRODUCTS
  申请人：GALAXY SURFACTANTS LTD.

  公开号：US20190106378A1

  公开（公告）日：2019-04-11

  Disclosed herein are antimicrobial N-Alkyl-N,N-bis(2-carboxyethyl)-N-benzyl ammonium chlorides of Formula I for preservation of home and personal care products. The invention further discloses a process for preparation of the antimicrobial compounds and home & personal care compositions comprising the N-Alkyl-N,N-bis(2-carboxyethyl)-N-benzyl ammonium chlorides of Formula I R=C 8-18 saturated or unsaturated alkyl group

  本文揭示了用于保护家居和个人护理产品的抗菌N-烷基-N,N-双(2-羧乙基)-N-苄基氯化铵的化合物I的公式。该发明还揭示了一种制备抗菌化合物和含有公式I的家居和个人护理组合物的方法。其中，R=C8-18饱和或不饱和烷基。
• 含有可电离脂质的肺部递送系统、其制备方法和应用
  申请人：晟迪生物医药（苏州）有限公司

  公开号：CN117919200A

  公开（公告）日：2024-04-26

  本发明提供含有可电离脂质的肺部递送系统、其制备方法和应用，属于生物医药技术领域。本发明的含有可电离脂质的肺部递送系统包括可电离脂质、辅助脂质和生物活性物质，不含聚合物缀合脂质，所述含有可电离脂质的肺部递送系统可以将生物活性物质递送至肺部。所述肺部递送系统具有粒径均一、安全性高的特点，能够将治疗剂高效地递送至肺部，且在雾化前后，颗粒性质如粒径、粒径分布系数、电位、包封率等颗粒特性均保持不变，为肺部疾病的治疗提供了安全有效的解决方案，具有广阔的应用前景。
• 空白脂质纳米颗粒在制备体内递送产品中的应用
  申请人：晟迪生物医药（苏州）有限公司

  公开号：CN117919199A

  公开（公告）日：2024-04-26

  本发明提供空白脂质纳米颗粒在制备体内递送产品中的应用，属于生物医药技术领域。所述空白脂质纳米颗粒在制备体内递送产品中的应用，包括将空白脂质纳米颗粒与生物学活性物质在溶剂中混合，得到基于空白脂质纳米颗粒的组合物的步骤；所述空白脂质纳米颗粒组成包括：可电离脂质、磷脂、胆固醇以及聚乙二醇缀合脂质。本发明采用所述空白脂质纳米颗粒，可根据使用者需求灵活调整生物学活性物质的剂量，并且可以通过静脉注射、肌肉注射、腹腔注射以及皮下注射等多种途径给药，均可获得理想的递送效果。
• Synthesis and characterization of Au nanocatalyst on modifed bentonite and silica and their applications for solvent free oxidation of cyclohexene with molecular oxygen
  作者：M.Shahabi nejad、G. Ghasemi、M.V. Martínez-Huerta、M. Ghiaci

  DOI：10.1016/j.molcata.2015.05.026

  日期：2015.9

  In the present work, the selective liquid phase oxidation of cyclohexene mainly to 2-cyclohexe-1-one has been investigated over gold nanoparticles (GNPs) with molecular oxygen in a solvent-free condition. Gold nanoparticles were synthesised on two modified supports of silica and bentonite. In this respect the surface of silica and bentonite was modified with organic ligands consist of thiol and thioester groups. The catalysts were characterized by TEM, XPS, N-2 adsorption/desorption, FT-IR, and CHNS techniques. TEM images show that the gold nanoparticles over modified bentonite and silica have diameters in the range Of 50 and less than 10 nm, respectively. The results show that the catalytic activity of gold nanoparticles over modified silica, SiO2-pA-Acrylate-Thioamide-Au (0), is much better than the gold nanoparticles immobilized on the modified bentonite, MEDPT@CP-bentonite-Au (0). The catalytic activity over SiO2-pA-Acrylate-Thioamide-Au (0) recycled catalyst remained at a satisfactory state after at least 4 cycles. Activity tests were carried out in an autoclave under solvent-free conditions. In order to obtain maximum conversion, the reaction parameters such as reaction temperature and time were optimized. Under optimized conditions, a maximum of 92% conversion and 97% selectivity was achieved with the SiO2-pA-Acrylate-Thioamide-Au (0) catalyst. (C) 2015 Elsevier B.V. All rights reserved.
• Preparation of Pd (0) and Pd (II) nanotubes and nanoparticles on modified bentonite and their catalytic activity in oxidation of ethyl benzene to acetophenone
  作者：M. Ghiaci、Z. Sadeghi、M.E. Sedaghat、H. Karimi-Maleh、J. Safaei-Ghomi、A. Gil

  DOI：10.1016/j.apcata.2010.03.062

  日期：2010.6

  The synthesis and application of palladium nanotubes and nanoparticles on modified bentonite was studied. In the first step, an organo-bentonite was prepared by the exchange of the exchangeable Na(+) cations of a homoionic Na-bentonite by cetyl pyridinium cations (CP-bentonite), especially in the range of low coverage ratios where surfactant ions are adsorbed through cation exchange with the counter ions of bentonite. At this stage, there will be a disordered liquid-like monolayer arrangement of alkyl chain within the gallery. This modified bentonite was loaded with the first generation of amidoamine hyperbranch cascade, 3,3'-(dodecylazanediyl) bis(N-(2-(2-aminoethylamino)ethyl)propanamide) (DAEP), which has a long aliphatic tail (C(12)) and a hydrophilic head. The solid/liquid interfacial layer of this architecturally designed bentonite (DAEP-bentonite) was utilized as a nanoreactor for the synthesis of nanoparticles of Pd(2+) and Pd(0). The structure, specific surface area, and porosity of bentonite are significantly altered by the incorporation of nanoparticles. These alterations were monitored by several techniques such as N(2) adsorption, X-ray diffraction (XRD), transmission electron microscopy (TEM) and electrochemical impedance spectroscopy (EIS). The size of the palladium nanoparticles prepared in this work was in the range of 5-15 nm. Solvent free oxidation of ethyl benzene using tert-butyl hydroperoxide as an oxidant showed that the palladium nanocatalysts prepared in this work, were highly active and selective. (C) 2010 Elsevier B.V. All rights reserved.