benzyl n-undecyl ether | 91842-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl n-undecyl ether
• 英文别名: benzyl undecyl ether；[(Undecyloxy)methyl]benzene；undecoxymethylbenzene
• CAS: 91842-62-5
• 化学式: C₁₈H₃₀O
• 分子量: 262.436
• InChiKey: VSIFAGKRCRXTLP-UHFFFAOYSA-N

物化性质

• 沸点：
  341.3±11.0 °C(Predicted)
• 密度：
  0.893±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  10-十一烯-1-醇 在 palladium on activated charcoal 氢气 、 sodium hydride 、 正丁胺 作用下， 以 乙醇 为溶剂， 25.0~60.0 ℃ 、310.27 kPa 条件下， 反应 1.0h， 生成 benzyl n-undecyl ether
  参考文献：
  名称：

  Effect of amines on O-benzyl group hydrogenolysis

  摘要：

  DOI：

  10.1021/jo00195a045

文献信息

• A novel method for synthesis of benzyl alkyl ethers using vanadium-based metal complex catalysts
  作者：R. I. Khusnutdinov、A. R. Bayguzina、L. I. Gallyamova、U. M. Dzhemilev

  DOI：10.1134/s0965544112040044

  日期：2012.7

  A novel method has been developed for the synthesis of benzyl alkyl ethers in 25–85% yields via the reaction of toluene with alcohols in a CCl4 medium catalyzed by Et3N-activated VO(acac)2.

  通过在Et 3 N活化的VO（acac）2催化下，在CCl 4介质中甲苯与醇的反应，已开发出一种新的合成苄基烷基醚的方法，产率为25-85％。
• IMIDAMIDE SPHINGOSINE KINASE INHIBITORS
  申请人：Lynch Kevin R.

  公开号：US20120214858A1

  公开（公告）日：2012-08-23

  Imidamide (amidine) analogs that can inhibit the activity of sphingosine kinase 1 and sphingosine kinase 2 (SphK1 & SphK2) are provided. The compounds can prevent angiogenesis in tumors.

  提供可以抑制神经酰胺激酶1和神经酰胺激酶2（SphK1和SphK2）活性的Imidamide（胺基）类似物。这些化合物可以预防肿瘤中的血管生成。
• Synthesis of Benzyl Alkyl Ethers by Intermolecular Dehydration of Benzyl Alcohol with Aliphatic Alcohols under the Effect of Copper Containing Catalysts
  作者：А. R. Bayguzina、L. I. Gimaletdinova、R. I. Khusnutdinov

  DOI：10.1134/s1070428018080055

  日期：2018.8

  Synthesis of benzyl alkyl ethers was performed in high yields by intermolecular dehydration of benzyl and primary, secondary, tertiary alcohols under the effect of copper containing catalysts. The formation of benzyl alkyl ethers occurs with participation of benzyl cation.

  在含铜催化剂的作用下，通过苄基与伯，仲，叔醇的分子间脱水，可以高收率地合成苄基烷基醚。苄基烷基醚的形成是在苄基阳离子的参与下发生的。
• LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS
  申请人：UNIVERSITY OF VIRGINIA PATENT FOUNDATION

  公开号：US20150210675A1

  公开（公告）日：2015-07-30

  The invention relates to inhibitors of Sphingosine Kinase enzymatic activity, and methods of treating diseases and disorders by administering inhibitors of Sphingosine Kinase enzymatic activity.

  本发明涉及抑制鞘氨醇激酶酶活性的抑制剂，以及通过给予鞘氨醇激酶酶活性抑制剂治疗疾病和疾患的方法。
• From Dimethylamine to Pyrrolidine: The Development of an Improved Nickel Pincer Complex for Cross-Coupling of Nonactivated Secondary Alkyl Halides
  作者：Pablo M. Perez Garcia、Thomas Di Franco、Alexandre Epenoy、Rosario Scopelliti、Xile Hu

  DOI：10.1021/acscatal.5b02324

  日期：2016.1.4

  Replacement of a dimethyl amino group of the amidobis(amine) nickel(II) pincer complex (1), [((N2N)-N-Me)-Ni-Cl], by a pyrrolidino group resulted in a new nickel(II) pincer complex (2), [((PNNN)-N-yr-N-Me)Ni-Cl]. Complex 2 is an efficient catalyst for Kumada and Suzuki-Miyaura cross-coupling of nonactivated secondary alkyl halides, while complex 1 is largely inactive. The significant activity difference is tentatively attributed to a minimal structural difference, which leads to a more hemilabile ligand.