4,4'-bis(allyloxy)biphenyl | 41481-62-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-bis(allyloxy)biphenyl
• 英文别名: 4,4'-bis(allylyloxy)biphenyl；4,4'-Bis(allyloxy)-1,1'-biphenyl；1-prop-2-enoxy-4-(4-prop-2-enoxyphenyl)benzene
• CAS: 41481-62-3
• 化学式: C₁₈H₁₈O₂
• 分子量: 266.34
• InChiKey: MAGNOYSFAOOVKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

上下游信息

• 上游原料

  中文名称	英文名称	CAS号	化学式	分子量
  4,4'-二羟基联苯	4,4'-Dihydroxybiphenyl	92-88-6	C12H10O2	186.21

反应信息

• 作为反应物：
  描述：

  4,4'-bis(allyloxy)biphenyl 在 双(乙腈)氯化钯(II) 、 氧气 、 sodium carbonate 、 copper dichloride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 10.0h， 以80%的产率得到2,2'-dimethyl[5,5']bibenzofuranyl
  参考文献：
  名称：

  Synthesis of 5,5′-bis-benzofurans and 5-arylbenzofurans

  摘要：

  A facile synthetic route of the tandem Claisen rearrangement/aerobic Wacker-type oxidative cyclization toward 5,5'-bis-benzofurans 2 and 5-arylbenzofurans 3 starting with bis-allyl aryl ethers 4 or allyl aryl ethers 5 with good yields is described. Skeletons 4 or 5 was prepared from 4,4'-biphenol (1) in moderate total yields via the known protocol. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.02.031
• 作为产物：
  描述：

  4-碘苯酚 在 palladium on activated charcoal 、 potassium carbonate 作用下， 以 水 、 丙酮 为溶剂， 生成 4,4'-bis(allyloxy)biphenyl
  参考文献：
  名称：

  小分子 NF-κB 抑制剂作为增强疫苗佐剂的免疫增强剂

  摘要：

  疫苗中添加佐剂可增强免疫反应并增强对疾病的保护。在过去的十年中，数百种合成免疫佐剂被创造出来，但许多都会诱导促炎细胞因子（包括 TNF-α 和 IL-6）达到不良水平。在这里，我们提出了小分子 NF-κB 抑制剂，可与免疫佐剂联合使用，以减少与耐受性差相关的标记物并改善疫苗接种的保护反应。此外，我们合成了和厚朴酚衍生物库，确定了几种有希望用于疫苗制剂的候选物。

  DOI：

  10.3389/fimmu.2020.511513

文献信息

• Polyaryl-poly(ethylene glycol) supports for solution-phase combinatorial
  申请人：Merck & Co., Inc.

  公开号：US05877214A1

  公开（公告）日：1999-03-02

  The present invention is directed to the certain polyaryl-poly(ethylene glycol) compounds ("polyaryl-PEG" compounds) which are useful as soluble polyvalent supports in the preparation of combinatorial libraries of compounds. The resultant combinatorial libraries are useful in screening for biologically active moieties in the drug discovery process or in developing compounds with desired physical and chemical properties.

  本发明涉及某些聚芳基-聚乙二醇化合物（“聚芳基-PEG”化合物），其可用作在制备化合物组合库中的可溶性多价支撑物。由此产生的化合物组合库可用于筛选药物发现过程中的生物活性基团，或开发具有期望的物理和化学性质的化合物。
• THERMOSETTING ALKOXYSILYL COMPOUND HAVING TWO OR MORE ALKOXYSILYL GROUPS, COMPOSITION AND CURED PRODUCT COMPRISING SAME, USE THEREOF, AND METHOD FOR PREPARING ALKOXYSILYL COMPOUND
  申请人：KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY

  公开号：US20180155370A1

  公开（公告）日：2018-06-07

  The present invention relates to: a thermosetting alkoxysilyl compound (hereinafter, referred to as “alkoxysilyl compound”)having two or more alkoxysilyl groups showing excellent heat-resistance characteristics in a composite; a composition and a cured product comprising the same; a use thereof; and a method for preparing an alkoxysilyl compound. The composition of an alkoxysilyl compound, comprising a novel alkoxysilyl compound according to the present invention shows, in a composite, improved heat-resistance characteristics, i.e., an effect of decreasing the CTE of the composition of an alkoxysilyl compound and not showing a glass transition temperature (hereinafter, referred to as “Tg-less”). Further, the cured product comprising an alkoxysilyl compound according to the present invention shows excellent flame retardant properties due to the alkoxysilyl groups.

  本发明涉及一种热固性烷氧基硅基化合物（以下简称“烷氧基硅基化合物”），其具有两个或两个以上的烷氧基硅基团，在复合材料中表现出优异的耐热特性；包括该烷氧基硅基化合物的组合物和固化产物；其用途；以及制备烷氧基硅基化合物的方法。根据本发明的一种烷氧基硅基化合物的组合物显示出改善的耐热特性，即降低烷氧基硅基化合物组合物的CTE并且不显示玻璃转变温度（以下简称“Tg-less”）的效果。此外，根据本发明的一种烷氧基硅基化合物的固化产物由于烷氧基硅基团表现出优异的阻燃性能。
• Silylated polycarbonate polymers, method of making, and articles
  申请人：Lens Jan Pleun

  公开号：US20080306294A1

  公开（公告）日：2008-12-11

  A silylated dihydroxy aromatic compound of the formula (1a); wherein G a and G b are each independently C 1-12 alkyl, —OSi(C 1-12 alkyl) 3 , C 1-12 arylalkyl, or —OSi(C 1-12 arylalkyl) 3 ; Z a and Z b are each independently a straight or branched C 2-18 alkylene, a C 8-18 arylalkylene, or a C 8-18 alkylarylene, X a is a direct bond, a heteroatom-containing group, or a C 1-18 organic group, and r and s are each independently 1 or 2 is disclosed.

  一种具有式(1a)的硅烷化二羟基芳香族化合物；其中Ga和Gb各自独立地为C1-12烷基、—OSi(C1-12烷基)3、C1-12芳基烷基或—OSi(C1-12芳基烷基)3；Za和Zb各自独立地为直链或支链的C2-18亚烷基、C8-18芳基亚烷基或C8-18烷基芳基亚烷基，Xa为直接键、含杂原子基团或C1-18有机基团，且r和s各自独立地为1或2。
• EPOXY COMPOUND HAVING ALKOXYSILYL GROUP, METHOD OF PREPARING THE SAME, COMPOSITION AND CURED PRODUCT COMPRISING THE SAME, AND USES THEREOF
  申请人：KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGY

  公开号：US20140179836A1

  公开（公告）日：2014-06-26

  Disclosed are an epoxy compound having an alkoxysilyl group, a composite of which exhibits good heat resistant properties and/or a cured product of which exhibits good flame retardant properties, a method of preparing the same, a composition comprising the same, and a cured product and a use of the composition. An alkoxysilylated epoxy compound comprising at least one of Chemical Formula S1 substituent and at least two epoxy groups in a core, a method of preparing the epoxy compound by an allylation, a claisen rearrangement, an epoxidation and an alkoxysilylation, an epoxy composition comprising the epoxy compound, and a cured product and a use of the composition are provided. The composite of the disclosed exhibits improved chemical bonding, good heat resistant properties, a low CTE, a high glass transition temperature or Tg-less The cured product of the composition exhibits good flame retardant properties.

  揭示了一种具有烷氧基硅基团的环氧化合物，其复合材料具有良好的耐热性能和/或其固化产物具有良好的阻燃性能，以及其制备方法，包括该化合物的组合物，固化产物和组合物的用途。所述的烷氧基硅化环氧化合物包括至少一种化学式S1取代基和至少两个环氧基团在核心中，通过烯丙基化、克莱森重排、环氧化和烷氧基硅化制备环氧化合物的方法，包括该环氧化合物的环氧组合物，固化产物和组合物的用途。所述的复合材料具有改善的化学键合、良好的耐热性能、低CTE、高玻璃转变温度或Tg-less。该组合物的固化产物具有良好的阻燃性能。
• Polyphosphoric Acid Promoted Synthesis of 10,11-Dihydrobenzo[<i>j</i>]fluoranthen-12-one
  作者：Meng-Yang Chang、Tein-Wei Lee、Ming-Hao Wu

  DOI：10.1021/ol3006979

  日期：2012.5.4

  A straightforward synthesis of 3,8-dimethoxy-10,11-dihydrobenzo[j]fluoranthen-12-ones 1 is reported in a seven-step route from biphenyl-4,4′-diol 2 via the transformation of a double Claisen rearrangement, cross metathesis with ethyl acrylate, and polyphosphoric acid (PPA)-promoted Friedel–Crafts electrophilic benzannulation in good yields.

  据报道，通过双克莱森重排的转化，由联苯-4,4'-二醇2以七步路线直接合成了3,8-二甲氧基-10,11-二氢苯并[ j ]荧蒽-12-酮1。，与丙烯酸乙酯和多磷酸（PPA）促进的Friedel–Crafts亲电苯环化交叉复分解反应，收率良好。