3-(2-hydroxyethylthiomethyl)pyridine | 136993-26-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(2-hydroxyethylthiomethyl)pyridine
• 英文别名: 2-[(pyridin-3-ylmethyl)sulfanyl]ethanol；2-[3]pyridylmethylsulfanyl-ethanol；2-[3]Pyridylmethylmercapto-aethanol；2-(3-pyridylmethylthio)ethanol；2-(pyridin-3-ylmethylthio)ethanol；2-(pyridin-3-ylmethylsulfanyl)ethanol
• CAS: 136993-26-5
• 化学式: C₈H₁₁NOS
• 分子量: 169.247
• InChiKey: SAWSUHYFYCIVHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  58.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-hydroxyethylthiomethyl)pyridine 在 m-chloroperoxybenzoic acid 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 生成 2-(pyridin-3-ylmethylsulphinyl)ethanol
  参考文献：
  名称：

  Oxathiane derivatives

  摘要：

  式子为##STR1##的Oxathiane衍生物，其中R代表烷基，A代表可选取代的苯基或含有1或2个氮原子的杂环芳基，可选取代为烷基，烷氧基或卤素，其盐具有药理活性，同时也有助于抑制头发脱落。

  公开号：

  US05389649A1
• 作为产物：
  描述：

  3-溴-5-氯甲基吡啶盐酸盐 在 咪唑 、 正丁基锂 、 sodium 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成 3-(2-hydroxyethylthiomethyl)pyridine
  参考文献：
  名称：

  Synthesis and Biological Evaluation of Some Acyclic Pyridine C-Nucleosides. Part Two

  摘要：

  3-Bromo-5-(2-hydroxyethylthiomethyl)pyridine ((7) under bar) was synthesized by reaction of 3-bromo-5-chloromethylpyridine hydrochloride ((6) under bar) with the mono sodium salt of 2-mercaptoethanol. 3-Bromo-5-hydroxymethylpyridine (<(10)under bar>) was, after protection as a silyl ether, converted to the 3-carboxy analogue using BuLi and CO2. After deprotection with NH4F, the alcohol function was chlorinated using SOCl2. Finally, attachment of the acyclic chain and ammonolysis gave the acyclic nicotinamide nucleosides. Treatment of the latter compounds with Lawesson's reagent gave the thioamide analogues. All compounds were identified by NMR and DCI-MS. The acyclic pyridine C-nucleosides were evaluated against a series of tumor-cell lines and a variety of viruses. No marked biological activity was found.

  DOI：

  10.1080/07328319608007388

文献信息

• THIAZOLIDINONE COMPOUNDS AND USE THEREOF
  申请人：National Health Research Institutes

  公开号：US20170253569A1

  公开（公告）日：2017-09-07

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

  一种含有化合物（I）的药物组合物，用于治疗与阿片受体相关的疾病。还公开了一种使用这种化合物治疗阿片受体相关疾病的方法。进一步公开了两组式（I）的噻唑烷酮化合物：（i）每种化合物的对映体过量大于90%；（ii）每种化合物被氘取代。
• Thiazolidinone compounds and use thereof
  申请人：National Health Research Institutes

  公开号：US10544113B2

  公开（公告）日：2020-01-28

  A pharmaceutical composition containing a compound of Formula (I) for treating an opioid receptor-associated condition. Also disclosed is a method for treating an opioid receptor-associated condition using such a compound. Further disclosed are two sets of thiazolidinone compounds of formula (I): (i) compounds each having an enantiomeric excess greater than 90% and (ii) compounds each being substituted with deuterium.

  一种含有用于治疗阿片受体相关疾病的式 (I) 化合物的药物组合物。还公开了一种使用此类化合物治疗阿片受体相关疾病的方法。进一步公开了两组式(I)的噻唑烷酮化合物：(i)对映体过量大于 90%的化合物和(ii)各自被氘取代的化合物。
• Vejdelek et al., Chemicke Listy, 1953, vol. 47, p. 49,53
  作者：Vejdelek et al.

  DOI：——

  日期：——
• OXATHIANE DERIVATIVES
  申请人：RHONE-POULENC RORER S.A.

  公开号：EP0511297A1

  公开（公告）日：1992-11-04
• US4246263A
  申请人：——

  公开号：US4246263A

  公开（公告）日：1981-01-20