3-mercapto-N-n-dodecylpropionamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-mercapto-N-n-dodecylpropionamide
• 英文别名: N-dodecyl-3-sulfanylpropanamide
• 化学式: C₁₅H₃₁NOS
• 分子量: 273.483
• InChiKey: ULQLHYXRXYRJKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  30.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Thioacetic acid S-(2-dodecylcarbamoyl-ethyl) ester 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 3-mercapto-N-n-dodecylpropionamide
  参考文献：
  名称：

  Control of Monolayer Assembly Structure by Hydrogen Bonding Rather Than by Adsorbate−Substrate Templating

  摘要：

  Stratified amide-containing self-assembled monolayers (SAMs) provide opportunities for investigating the fundamental dependence of supramolecular structure upon molecular constitution. We report a series of amide-containing alkanethiol SAMs (C-n-1AT/Au, n = 9, 11-16, 18) in which the hydrophobic overlayer thickness is systematically varied and the thickness of the polar region is held constant. The results from X-ray photoelectron spectroscopy, contact angle goniometry, reflective IR spectroscopy, and electrochemical measurements provide a consistent structural picture of the series. The amide underlayers in all the SAMs are well-ordered and extensively hydrogen bonded. However, the alkyl chains are disordered below n = 15. Comparison of the assembly structures shows that the chain length threshold for alkyl ordering is several methylenes higher than in n-alkanethiol SAMs. This indicates that alkyl chains adjacent to an amide underlayer are destabilized as compared to n-alkanethiols and that the amide underlayer destructively interferes with alkyl close packing as compared to the Au(lll)-sulfur template. However, the amide regions of the SAMs are all well-ordered, showing that the amide sublayer acts as a "template" that is independent of alkyl chain length. The amide region dominates over gold-sulfur epitaxy in establishing the structure of these assemblies, and the amide-alkyl boundary provides an example of a "rigid-elastic" buried organic interface. Implications of these studies for molecular control of bulk properties, lipid-linked protein structure and function, buried organic interfaces in other systems, rationally designed ordered multilayers, and hybrid supramolecular systems are discussed.

  DOI：

  10.1021/ja9901011

文献信息

• PATTERNING PROCESS
  申请人：Zu Lijun

  公开号：US20110226733A1

  公开（公告）日：2011-09-22

  A patterning process comprises (a) providing at least one substrate having at least one major surface; (b) providing at least one patterning composition comprising at least one functionalizing molecule that is a perfluoropolyether organosulfur compound; (c) applying the patterning composition to the major surface of the substrate in a manner so as to form at least one functionalized region and at least one unfunctionalized region of the major surface; and (d) etching at least a portion of the unfunctionalized region.

  一种图案化处理过程包括：(a)提供至少一个具有至少一个主表面的基板；(b)提供至少一种图案化组合物，其中包含至少一种功能化分子，该分子是一种全氟聚醚有机硫化合物；(c)以一种方式将图案化组合物应用于基板的主表面，以形成至少一个主表面的功能化区域和至少一个未功能化区域；(d)蚀刻至少部分未功能化区域。
• Neue schwefelhaltige Phospholipide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0050327B1

  公开（公告）日：1984-06-20
• INSULIN RECEPTOR PARTIAL AGONISTS
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US20170313755A1

  公开（公告）日：2017-11-02

  Disclosed herein are insulin analog conjugates comprising an insulin agonist covalently linked to an insulin antagonist peptide. The conjugates are high potency insulin agonists but with decreased maximal activity relative to the maximal activity of native insulin.
• US8858813B2
  申请人：——

  公开号：US8858813B2

  公开（公告）日：2014-10-14
• US9593156B2
  申请人：——

  公开号：US9593156B2

  公开（公告）日：2017-03-14