4-dodecylcarbamoylpyridine | 81660-72-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-dodecylcarbamoylpyridine
• 英文别名: N-dodecylcarbamoylpyridine；N-dodecylisonicotinamide；N-1-dodecylisonicotinamide；N-dodecylpyridine-4-carboxamide
• CAS: 81660-72-2
• 化学式: C₁₈H₃₀N₂O
• 分子量: 290.449
• InChiKey: APGIDZYILREERN-UHFFFAOYSA-N

物化性质

• 沸点：
  460.3±18.0 °C(Predicted)
• 密度：
  0.953±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3-丙烷磺内酯 、 4-dodecylcarbamoylpyridine 以 甲苯 为溶剂， 以74%的产率得到dodecylcarbamoyl-1-(3-sulfopropyl)pyridinium betaine
  参考文献：
  名称：

  3D Continuous Water Nanosheet as a Gyroid Minimal Surface Formed by Bicontinuous Cubic Liquid-Crystalline Zwitterions

  摘要：

  Co-organization of amphiphilic zwitterions and bis(trifluoromethanesulfonyl)imide led to the formation of bicontinuous cubic liquid-crystalline structures having 3D continuous hydrophilic gyroid minimal surface. The gyroid surface, incorporating a small amount of water, provided extremely thin but macroscopically continuous water nanosheet with a thickness of approximately 5 angstrom. The water nanosheet functioned as alignment free proton conduction pathway.

  DOI：

  10.1021/ja304124w
• 作为产物：
  描述：

  异烟酸 在 吡啶 、 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 4-dodecylcarbamoylpyridine
  参考文献：
  名称：

  形成液晶相的两亲性两性离子的设计及锂盐添加对其相行为的影响

  摘要：

  我们制备了基于吡啶的两亲性两性离子，并在存在和不存在锂盐的情况下检查了它们的液晶 (LC) 相行为。添加锂盐诱导纳米...

  DOI：

  10.1246/bcsj.20140049

文献信息

• An Efficient Heterobimetallic Lanthanide Alkoxide Catalyst for Transamidation of Amides under Solvent-Free Conditions
  作者：Hongting Sheng、Ruijie Zeng、Wenjuan Wang、Shuwen Luo、Yan Feng、Jing Liu、Weijian Chen、Manzhou Zhu、Qingxiang Guo

  DOI：10.1002/adsc.201600373

  日期：2017.1.19

  lanthanide catalysts showed high catalytic activity and a wide scope of substrates with good to excellent yields under solvent‐free conditions. Efficient activation of the transamidation can be realized by the above complexes acting as cooperative acid–base bifunctional catalysts, which are proposed to be responsible for the higher reactivity in comparison with simple monometallic catalysts.

  已经开发出一种实用的杂双金属镧系元素催化的伯，仲和叔酰胺与脂肪族和芳香族胺的酰胺化反应。该方法还应用于弱反应性硫代酰胺，以证明其多功能性和广泛的底物范围。杂双金属镧系元素催化剂在无溶剂条件下显示出高催化活性和多种底物，收率良好至优异。可以通过上述配合物作为酸基双官能催化剂，来实现转酰胺基的有效活化，与简单的单金属催化剂相比，这些络合物被认为具有更高的反应活性。
• [EN] MOLECULES AND COMPOSITIONS THAT INHIBIT GRAM NEGATIVE BACTERIA AND THEIR USES<br/>[FR] MOLÉCULES ET COMPOSITIONS INHIBANT DES BACTÉRIES À GRAM NÉGATIF, ET LEURS UTILISATIONS
  申请人：UNIV PRINCETON

  公开号：WO2015042363A1

  公开（公告）日：2015-03-26

  Antivirulence strategies to combat Pseudomonas aeruginosa, are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.

  防毒力策略用于对抗铜绿假单胞菌，其中一种策略包括合成一系列化合物，抑制该病原体产生的一种氧化还原活性毒力因子——吡菌素。另一种相关策略包括合成抑制两种铜绿假单胞菌群体感应受体LasR和RhlR的化合物，抑制吡菌素的产生，并抑制生物膜形成。
• Anionic or cationic dendrimer antimicrobial or antiparasitic compositions
  申请人：STARPHARMA LIMITED

  公开号：US20030129158A1

  公开（公告）日：2003-07-10

  To inhibit, prophylactically or therapeutically, a bacterial, yeast, fungal, or parasitic agent in a patient, an effective amount of a dendrimer is administered to the patient, which dendrimer has a plurality of terminal groups, at least one of which has an anionic- or cationic-moiety covalently bonded or linked thereto. The anionic-containing moiety is not a disaccharide or oligosaccharide moiety, and, where the anionic-containing moiety is a neuraminic- or sialic acid-containing moiety, it is modified in the 4-position by substitution with an amino, amido, cyano, azido or guanido group, or is unsaturated.

  为了抑制、预防或治疗患者体内的细菌、酵母菌、真菌或寄生虫，需要向患者注射有效量的树状分子，该树状分子具有多个末端基团，其中至少一个基团与其共价键合或连接成阳离子或阴离子基团。阴离子含有的基团不是二糖或寡糖基团，当阴离子含有的基团是神经酰胺酸或唾液酸含有的基团时，在4位被氨基、酰胺、氰基、叠氮基或鸟氨酸基团取代或不饱和。
• Mechanistic Insights into the Charge Transfer Dynamics of Photocatalytic Water Oxidation at the Lipid Bilayer–Water Interface
  作者：Hongwei Song、Agnese Amati、Andrea Pannwitz、Sylvestre Bonnet、Leif Hammarström

  DOI：10.1021/jacs.2c06842

  日期：2022.10.26

  transfer from PS+ to catalyst is rather fast in homogeneous solution (kobs > 1 × 104 s–1 at [catalyst] > 50 μM), in liposomes at pH = 4, the reaction is rather slow (kobs ≈ 17 s–1 for 5 μM catalyst in 100 μM DMPC lipid). Overall, the better understanding of these productive and unproductive pathways explains what limits the rate of photocatalytic water oxidation in liposomal vs homogeneous systems, which

  光系统 II 是天然的水氧化系统，是嵌入磷脂膜中的大型蛋白质复合物。一个更简单的光催化水氧化系统由用两亲性钌 (II)-三-联吡啶光敏剂 (PS) 和 6,6'-dicarboxylato-2,2'-联吡啶-钌 (II) 催化剂 (Cat) 功能化的脂质体组成水溶性牺牲电子受体（Na 2 S 2 O 8). 然而，将这种光催化系统嵌入脂质体膜对光催化水氧化机制的影响尚不清楚。在这里，光谱工具已经确定了几种现象，这些现象解释了与类似的均相系统相比，水光氧化脂质体的动力学截然不同。首先，S 2 O 8 2–在脂质体表面对光激发的 PS* 的氧化猝灭仅通过静态猝灭发生，而在均相系统中观察到动态猝灭。此外，淬灭反应后的电荷分离效率远小于单位，与 PS +的定量生成相反在均匀溶液中。同时，膜结合 PS 的局部高浓度会在 10:1–40:1 的脂质-PS 摩尔比下引起自淬灭。最后，虽然从 PS +到催化剂的空穴转移在均相溶液中相当快（k
• New cephem compounds and processes for preparation thereof
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0042154A1

  公开（公告）日：1981-12-23

  New cephem compounds of the formula: wherein R1 is amino or a protected amino group; R2 is hydrogen, lower aliphatic hydrocarbon group which may be substituted with suitable substituent(s), cyclo(lower)alkyl or cyclo(lower)alkenyl; and R3 is a thiazolio group which may be substituted with suitable substituent(s) or a pyridinio group substituted with substituent(s) selected from the group consisting of halogen, cyano, hydroxy, amino, acylamino, lower alkanoyl, hydroxycarbamoyl, alkylcarbamoyl, carboxy, protected carboxy, lower alkyl, hydroxy(lower)alkyl, sulfo(lower)-alkyl, protected amino(lower)alkyl, amino(lower)alkyl, carboxy(lower)alkyl and hydroxyimino(lower)alkyl; and pharmaceutically acceptable salts thereof, and process for their preparation, and also a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient. The invention also relates to the starting compounds. and their preparation.

  新的 Cephem 化合物，其式如下 式中 R1 是氨基或受保护的氨基； R2 是氢、可被适当取代基取代的低脂族烃基、环（低）烷基或环（低）烯基；以及 R3 是可被适当取代基取代的噻唑基或被选自卤素、氰基、羟基、氨基、酰氨基、低级烷酰基、羟基氨基甲酰基、烷基氨基甲酰基、羧基、受保护羧基、低级烷基、羟基（低级）烷基、磺酰（低级）烷基、受保护氨基（低级）烷基、氨基（低级）烷基、羧基（低级）烷基和羟基亚氨基（低级）烷基组成的取代基取代的吡啶基；和它们的药学上可接受的盐，以及它们的制备工艺，还有一种药物组合物，其中作为有效成分，上述化合物与药学上可接受的、基本上无毒的载体或赋形剂结合在一起。本发明还涉及起始化合物。 及其制备方法。