methyl 1-O-(4-ethoxycarbonyl-2-methoxyphenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate | 1376574-28-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 1-O-(4-ethoxycarbonyl-2-methoxyphenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate
• CAS: 1376574-28-5
• 化学式: C₂₃H₂₈O₁₃
• 分子量: 512.468
• InChiKey: BQZZZKPEWVGVPM-BCYLSMINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.94
• 重原子数：
  36.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  159.19
• 氢给体数：
  0.0
• 氢受体数：
  13.0

反应信息

• 作为反应物：
  描述：

  methyl 1-O-(4-ethoxycarbonyl-2-methoxyphenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate 在 水 、 potassium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 72.0h， 生成 1-O-(2-methoxy-4-carboxyphenyl)-β-D-glucuronic acid
  参考文献：
  名称：

  Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids

  摘要：

  Epidemiological studies indicate that flavonoid intake is inversely associated with the risk of coronary heart disease, yet the mechanisms responsible for their bioactivity are still a matter of debate. Based on the rapid and extensive metabolism of most flavonoids, their health effects most likely result from the biological activity of their metabolites. However, a lack of commercially available compounds/standards has prevented the study of metabolite bioactivity and resulted in a focus on non-physiologically relevant precursor/parent structures. This paper details the synthesis of a series of phenolic glucuronide 1a-e and sulfate 2a-e derivates as candidate metabolites for use as reference compounds in metabolic profiling studies and for the exploration of flavonoid bioactivity. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2012.03.100
• 作为产物：
  描述：

  香草酸乙酯 、 3,4,6-三邻乙酰基-alpha-D-吡喃葡萄糖 1,2-(原酸甲酯) 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以83%的产率得到methyl 1-O-(4-ethoxycarbonyl-2-methoxyphenyl)-2,3,4-tri-O-acetyl-β-D-glucopyranosiduronate
  参考文献：
  名称：

  Flavonoid metabolism: the synthesis of phenolic glucuronides and sulfates as candidate metabolites for bioactivity studies of dietary flavonoids

  摘要：

  Epidemiological studies indicate that flavonoid intake is inversely associated with the risk of coronary heart disease, yet the mechanisms responsible for their bioactivity are still a matter of debate. Based on the rapid and extensive metabolism of most flavonoids, their health effects most likely result from the biological activity of their metabolites. However, a lack of commercially available compounds/standards has prevented the study of metabolite bioactivity and resulted in a focus on non-physiologically relevant precursor/parent structures. This paper details the synthesis of a series of phenolic glucuronide 1a-e and sulfate 2a-e derivates as candidate metabolites for use as reference compounds in metabolic profiling studies and for the exploration of flavonoid bioactivity. (C) 2012 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2012.03.100