N-Boc-4-acetylphenylalanine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Boc-4-acetylphenylalanine
• 英文别名: Boc-4-acetyl-L-phenylalanine；(2S)-3-(4-acetylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
• 化学式: C₁₆H₂₁NO₅
• 分子量: 307.346
• InChiKey: YVBRFBNRDRVUAF-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-Boc-4-acetylphenylalanine 在 potassium tert-butylate 、 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 0.3h， 生成
  参考文献：
  名称：

  COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES

  摘要：

  公开号：

  EP1828224B1
• 作为产物：
  描述：

  4-乙酰基-L-苯基丙氨酸 、 二碳酸二叔丁酯 在 碳酸氢钠 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 7.0h， 以100%的产率得到N-Boc-4-acetylphenylalanine
  参考文献：
  名称：

  COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES

  摘要：

  公开号：

  EP1828224B1

文献信息

• Compounds and methods for treatment of HCV
  申请人：Li Guolin

  公开号：US20090041723A1

  公开（公告）日：2009-02-12

  Aryl substituted pyrazole derivatives are provided, as well as processes for their preparation. The invention also provides compositions and methods for the treatment of HCV by administering a compound of the present invention, alone or in combination with additional antiviral agents, in a therapeutically effective amount.

  本发明提供了取代芳基吡唑衍生物，以及其制备方法。本发明还提供了组合物和方法，通过单独或与其他抗病毒药物联合使用本发明的化合物来治疗HCV，以达到治疗效果。
• Methods and compositions for ribosomal synthesis of macrocyclic peptides
  申请人：University of Rochester

  公开号：US10544191B2

  公开（公告）日：2020-01-28

  Methods and compositions are provided for generating macrocyclic peptides from genetically encoded, ribosomally produced polypeptide precursors. Also provided are nucleic acid molecules, polypeptides, and methods for generating combinatorial libraries of macrocyclic peptides. These methods can be used to produce vast libraries of conformationally constrained peptide ligands as well as facilitate the functional screening of these libraries to identify compound(s) with desired activity properties.

  提供了从基因编码、核糖体产生的多肽前体生成大环肽的方法和组合物。还提供了核酸分子、多肽和生成大环肽组合库的方法。这些方法可用于产生大量的构象受限多肽配体库，以及促进这些库的功能筛选，以确定具有所需活性特性的化合物。
• [EN] METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LA SYNTHÈSE RIBOSOMIQUE DE PEPTIDES MACROCYCLIQUES
  申请人：UNIV ROCHESTER

  公开号：WO2015100277A9

  公开（公告）日：2015-10-01
• Identification of potent phenyl imidazoles as opioid receptor agonists
  作者：Henry J. Breslin、Chaozhong Cai、Tamara A. Miskowski、Santosh V. Coutinho、Sui-Po Zhang、Pamela Hornby、Wei He

  DOI：10.1016/j.bmcl.2006.01.082

  日期：2006.5

  Using previously reported opioid receptor (OR) agonist analogs 4a-c as starting points, the structure-activity relationship (SAR) for their related series has been further refined. This SAR Study has led to the identification of 2,6-di-Me-Tyr (DMT) analogs 4h and 4j as the most potent OR agonist within the series. in addition, it was discovered that 4-(aminocarbonyl)-2,6-dimethyl-Phe is a reasonable bioisostere surrogate for the DMT moiety, as supported by the OR activities Of Compounds 4x and 4y. (C) 2006 Elsevier Ltd. All rights reserved.
• METHODS AND COMPOSITIONS FOR RIBOSOMAL SYNTHESIS OF MACROCYCLIC PEPTIDES
  申请人：University Of Rochester

  公开号：EP3087088A2

  公开（公告）日：2016-11-02