N-(hydroxyethyl)-N-methylbutylamide | 152656-51-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(hydroxyethyl)-N-methylbutylamide
• 英文别名: N-(2-hydroxyethyl)-N-methylbutanamide
• CAS: 152656-51-4
• 化学式: C₇H₁₅NO₂
• 分子量: 145.202
• InChiKey: DVABXBSMVJVVKK-UHFFFAOYSA-N

物化性质

• 沸点：
  256.0±23.0 °C(Predicted)
• 密度：
  0.994±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(hydroxyethyl)-N-methylbutylamide 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 N-methyl-N-(2-oxoethyl)butylamide
  参考文献：
  名称：

  EP1721905

  摘要：

  公开号：
• 作为产物：
  描述：

  N-甲基-2-羟基乙胺 、 丁酰氯 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 0.33h， 生成 N-(hydroxyethyl)-N-methylbutylamide
  参考文献：
  名称：

  EP1721905

  摘要：

  公开号：

文献信息

• Thiadiazoline derivative
  申请人：Murakata Chikara

  公开号：US20070213380A1

  公开（公告）日：2007-09-13

  (wherein R 1 and R 4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R 5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R 2 represents —C(═W)R 6 or the like; R 3 represents a hydrogen atom, —C(═W A )R 6A , or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.

  本发明提供了一种以上述通式(I)所代表的噻二唑衍生物或其药学上可接受的盐为活性成分的抗肿瘤剂。其中R1和R4相同或不同，每个表示氢原子，取代或未取代的低级烷基，取代或未取代的低级炔基，取代或未取代的低级烯基或类似物；R5表示取代或未取代的杂环基，取代或未取代的芳基或类似物；R2表示-C(═W)R6或类似物；R3表示氢原子，-C(═WA)R6A或类似物。
• THIADIAZOLINE DERIVATIVE
  申请人：MURAKATA Chikara

  公开号：US20080207706A1

  公开（公告）日：2008-08-28

  (wherein R 1 and R 4 are the same or different and each represents a hydrogen atom, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkynyl, substituted or unsubstituted lower alkenyl, or the like; R 5 represents a substituted or unsubstituted heterocyclic group, substituted or unsubstituted aryl, or the like; R 2 represents —C(═W)R 6 or the like; R 3 represents a hydrogen atom, —C(═W A )R 6A , or the like) Antitumor agents which comprises a thiadiazoline derivative represented by the aforementioned general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient are provided.

  提供了一种抗肿瘤剂，其包括由上述一般式（I）表示的噻二唑啉衍生物或其药学上可接受的盐作为活性成分，其中R1和R4相同或不同，每个代表氢原子，取代或未取代的低碳基，取代或未取代的低炔基，取代或未取代的低烯基或类似物; R5代表取代或未取代的杂环基，取代或未取代的芳基或类似物; R2代表-C（═W）R6或类似物; R3代表氢原子，-C（═WA）R6A或类似物。
• Thiazole derivative
  申请人：Sato Masakazu

  公开号：US20070154428A1

  公开（公告）日：2007-07-05

  A thiazolylimidazole derivative represented by the formula or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient, wherein: X 1 and X 2 are different from each other and represent a sulfur atom or a carbon atom; R 1 represents a phenyl group; a substituted phenyl group; a phenyl group condensed with a hetero aromatic ring; a pyridyl group; or a pyridyl group condensed with a hetero aromatic ring; R 2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms substituted with 1 to 5 halogen atoms, an alkoxy group having 1 to 6 carbon atoms, an alkanoyl group having 1 to 5 carbon atoms, or a hydroxyalkyl group having 1 to 6 carbon atoms, A represents a group which is represented by the formula. The present invention provides an inhibitory substance against ALK5 which is a TGF-β type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.

  一种由以下公式表示的噻唑咪唑衍生物或其药学上可接受的盐，以及ALK5抑制剂，作为治疗脱发或促进头发生长的活性成分。其中：X1和X2不同，分别表示硫原子或碳原子；R1表示苯基；取代苯基；与杂环芳香环融合的苯基；吡啶基；或与杂环芳香环融合的吡啶基；R2表示氢原子，卤素原子，具有1到6个碳原子的烷基，具有1到6个碳原子的烷基，该烷基被1到5个卤素原子取代，具有1到6个碳原子的烷氧基，具有1到5个碳原子的烷酰基或具有1到6个碳原子的羟基烷基；A表示由以下公式表示的基团。本发明提供了一种抗TGF-β类型I受体ALK5的抑制物质，并基于其新颖的活性提供了一种促进头发生长的刺激剂或头发生长剂。
• Mitotic kinesin inhibitor
  申请人：Murakata Chikara

  公开号：US20070155804A1

  公开（公告）日：2007-07-05

  A mitotic kinesin Eg5 inhibitor which comprises a thiadiazoline derivative represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient: [wherein R 1 represents a hydrogen atom and the like, R 2 represents a hydrogen atom, —C(═W)R 6 (wherein W represents an oxygen atom or a sulfur atom, and R 6 represents substituted or unsubstituted lower alkyl and the like) and the like, R 3 represents —C(═Z)R 19 (wherein Z represents an oxygen atom or a sulfur atom, and R 19 represents substituted or unsubstituted lower alkyl and the like) and the like, R 4 represents substituted or unsubstituted lower alkyl and the like, and R 5 represents substituted or unsubstituted aryl and the like] and the like are provided.

  一种有丝分裂动力蛋白Eg5抑制剂，其包括由通式（I）表示的噻二唑衍生物或其药学上可接受的盐作为活性成分：[其中R1代表氢原子等，R2代表氢原子，-C（═W）R6（其中W代表氧原子或硫原子，R6代表取代或未取代的低级烷基等）等，R3代表-C（═Z）R19（其中Z代表氧原子或硫原子，R19代表取代或未取代的低级烷基等）等，R4代表取代或未取代的低级烷基等，R5代表取代或未取代的芳基等]等。
• THIAZOLE DERIVATIVE
  申请人：Sato Masakazu

  公开号：US20100216787A1

  公开（公告）日：2010-08-26

  A thiazolylimidazole derivative represented by the formula or a pharmaceutically acceptable salt thereof, and an ALK5 inhibitor, an therapeutic agent for alopecia or a hair growth agent having the above as an active ingredient, wherein: X 1 and X 2 are different from each other and represent a sulfur atom or a carbon atom; R 1 represents a phenyl group; a substituted phenyl group; a phenyl group condensed with a hetero aromatic ring; a pyridyl group; or a pyridyl group condensed with a hetero aromatic ring; R 2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkyl group having 1 to 6 carbon atoms substituted with 1 to 5 halogen atoms, an alkoxy group having 1 to 6 carbon atoms, an alkanoyl group having 1 to 5 carbon atoms, or a hydroxyalkyl group having 1 to 6 carbon atoms, A represents a group which is represented by the formula. The present invention provides an inhibitory substance against ALK5 which is a TGF-β type I receptor and provides a hair growth stimulant or a hair growth agent based on its novel activities.

  一种由式表示的噻唑咪唑衍生物或其药学上可接受的盐，并且一种ALK5抑制剂，用作脱发的治疗剂或具有上述物质作为活性成分的生发剂，其中：X1和X2不同且表示硫原子或碳原子；R1表示苯基；取代苯基；与杂环芳香环融合的苯基；吡啶基；或与杂环芳香环融合的吡啶基；R2表示氢原子、卤原子、具有1至6个碳原子的烷基、1至6个碳原子的烷基，其上取代有1至5个卤原子、具有1至6个碳原子的烷氧基、具有1至5个碳原子的烷酰基或具有1至6个碳原子的羟基烷基；A表示由式表示的基团。本发明提供了一种抗ALK5的抑制物质，该物质是一种TGF-β类型I受体，并基于其新的活性提供了一种生发刺激剂或生发剂。