dimethyl 3-methyl-3-phenoxy-2-oxo-butylphosphonate | 40665-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: dimethyl 3-methyl-3-phenoxy-2-oxo-butylphosphonate
• 英文别名: dimethyl 3-methyl-2-oxo-3-phenoxybutylphosphonate；dimethyl 2-oxo-3-methyl-3-phenoxybutylphosphonate；dimethyl 3,3-dimethyl-3-phenoxy, 2-oxo-propylphosphonate；1-dimethoxyphosphoryl-3-methyl-3-phenoxybutan-2-one
• CAS: 40665-74-5
• 化学式: C₁₃H₁₉O₅P
• 分子量: 286.265
• InChiKey: UCRKAQICLXTYQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  dimethyl 3-methyl-3-phenoxy-2-oxo-butylphosphonate 以85%的产率得到
  参考文献：
  名称：

  OHNO, KIYOTAKA;NAGASE, HIROSHI;ISHIKAWA, MAMORU;MATSUMOTO, KARUHISA;NISHI+

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基2-甲基-2-(苯氧基)丙酸酯 生成 dimethyl 3-methyl-3-phenoxy-2-oxo-butylphosphonate
  参考文献：
  名称：

  SHIBASAKI, MASAKATSU;TAKAHASHI, ATSUO;AOKI, TSUYOSHI;SATO, HIROYASU;NARIT+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 1647-1649

  摘要：

  DOI：

文献信息

• 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI.sub.2 derivatives
  申请人：Toray Industries, Inc.

  公开号：US04775692A1

  公开（公告）日：1988-10-04

  Disclosed herein are novel prostaglandin I.sub.2 (PGI.sub.2) derivatives exhibiting excellent in vivo duration and activities, said derivatives being represented by the general formula: ##STR1## wherein R.sub.1, X, R.sub.2 and R.sub.3 are as defined herein.

  本文披露了一种展现出优异体内持续时间和活性的新型前列腺素I.sub.2（PGI.sub.2）衍生物，所述衍生物由以下一般式表示：##STR1##其中R.sub.1、X、R.sub.2和R.sub.3如本文所定义。
• 16-Phenoxy prostaglandin A2 analogs
  申请人：The Upjohn Company

  公开号：US04087616A1

  公开（公告）日：1978-05-02

  Prostaglandin-type compounds with a phenoxy or substituted-phenoxy substituent at the C-16 position are disclosed, with processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, labor inducement at term, and wound healing.

  在C-16位置具有苯氧基或取代苯氧基取代基的前列腺素类化合物已被披露，以及制备它们的方法。这些化合物可用于多种药理目的，包括抗溃疡、抑制血小板聚集、增加鼻腔通气、催产以及伤口愈合。
• Synthesis of cis-bicyclo(4.3.0)non-2-ene derivatives. The potent homoisocarbacyclin analogs.
  作者：Masakatsu SHIBASAKI、Atsuo TAKAHASHI、Tsuyoshi AOKI、Hiroyasu SATO、Sen-ichi NARITA

  DOI：10.1248/cpb.37.1647

  日期：——

  Synthesis of homoisocarbacyclin has been achieved efficiently by a general strategy with stereo- and regiochemical control. One of homoisocarbacyclin derivatives, 3-oxa homoisocarbacyclin analog (4), was shown to be potently active in inhibiting gastric ulcer. Another analog, conjugated diene derivative (5), was found to have a biological profile similar to prostacyclin.

  已经通过立体和区域化学控制的一般策略有效地实现了高异碳环素的合成。均异碳环素衍生物之一，3-氧杂均碳环素类似物（4）被证明在抑制胃溃疡方面具有有效活性。发现另一种类似物，共轭二烯衍生物（5），具有与前列环素相似的生物学特性。
• 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0232776A2

  公开（公告）日：1987-08-19

  Disclosed herein are novel prostaglandin I2 (PGI2) derivatives exhibiting excellent in vivo duration and acitivities, said derivatives being represented by the general formula: wherein R1, X, R2 and R3 are as defined herein.

  本文公开了新型前列腺素 I2 (PGI2) 衍生物，其在体内的持续时间和活性极佳，所述衍生物由通式表示： 其中 R1、X、R2 和 R3 如本文所定义。
• Prostacyclin analogue and anti-ulcer composition containing it as active ingredient
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP0273216A2

  公开（公告）日：1988-07-06

  A prostacyclin analogue having the formula: wherein R¹ is a hydrogen atom or a lower alkyl group; R² and R³ each is a hydrogen atom or a lower alkyl group; R⁴ is a hydrogen atom, a halogen atom or a lower alkoxy group.

  一种前列环素类似物，其式如下 其中 R¹ 为氢原子或低级烷基；R² 和 R³ 各为氢原子或低级烷基；R⁴ 为氢原子、卤素原子或低级烷氧基。