[4-Oxo-5-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-4,5-dihydro-[1,3,5]triazin-2-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester | 431890-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-Oxo-5-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-4,5-dihydro-[1,3,5]triazin-2-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester
• CAS: 431890-06-1
• 化学式: C₂₃H₃₅N₅O₈Si₂
• 分子量: 565.731
• InChiKey: UAAIGBZJCLJHEO-XUVXKRRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  38.0
• 可旋转键数：
  11.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  156.94
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  [4-Oxo-5-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-4,5-dihydro-[1,3,5]triazin-2-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester 以 N,N-二甲基甲酰胺 为溶剂， 反应 96.0h， 以65%的产率得到2'-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]-5-azacytidine
  参考文献：
  名称：

  Synthesis and Properties of Oligonucleotides Containing 5-Aza-2′-deoxycytidine

  摘要：

  The preparation of a protected derivative of 5-aza-2'-deoxycytidine carrying the 2-(p-nitrophenyl)ethyl group is described. The new derivative is useful for the preparation of oligonucleotides containing 5-aza-2'-deoxycytidine using a special methodology that avoids the use of ammonia.

  DOI：

  10.1080/07328319708006144
• 作为产物：
  描述：

  地西他滨 生成 [4-Oxo-5-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-4,5-dihydro-[1,3,5]triazin-2-yl]-carbamic acid 2-(4-nitro-phenyl)-ethyl ester
  参考文献：
  名称：

  Synthesis and Properties of Oligonucleotides Containing 5-Aza-2′-deoxycytidine

  摘要：

  The preparation of a protected derivative of 5-aza-2'-deoxycytidine carrying the 2-(p-nitrophenyl)ethyl group is described. The new derivative is useful for the preparation of oligonucleotides containing 5-aza-2'-deoxycytidine using a special methodology that avoids the use of ammonia.

  DOI：

  10.1080/07328319708006144