N-(1-ethoxyethyl)-N'-methyl-acetamide | 17361-96-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(1-ethoxyethyl)-N'-methyl-acetamide
• 英文别名: N-(methyl)-N-(1-ethoxyethyl)acetamide；N-α-ethoxyethyl-N-methylacetamide；N-(1-ethoxyethyl)-N-methylacetamide
• CAS: 17361-96-5
• 化学式: C₇H₁₅NO₂
• 分子量: 145.202
• InChiKey: ISIHNWKJZISSBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-ethoxyethyl)-N'-methyl-acetamide 生成 N-甲基-N-乙烯基乙酰胺
  参考文献：
  名称：

  Process for production of N-vinyl compound

  摘要：

  本发明提供了一种生产N-乙烯基化合物的方法，包括将N-（-烷氧基烷基）化合物经气相分子内醇消除反应，直接一步转化为N-乙烯基化合物，其中使用含有磷和碱金属和/或碱土金属的固体氧化物作为催化剂。该方法不需要使用任何溶剂或任何辅助原料，因此可以简单安全地生产N-乙烯基化合物，而不会产生任何与辅助原料相关的废弃物。

  公开号：

  US05700946A1
• 作为产物：
  描述：

  N-(2-Ethoxyethyl)-acetamid 在 氨 、 硫酸二甲酯 作用下， 生成 N-(1-ethoxyethyl)-N'-methyl-acetamide
  参考文献：
  名称：

  Process for the preparation of N-vinyl-N-alkyl-carboxylic acid amides

  摘要：

  N-乙基羧酸酰胺经过3个阶段的过程制备N-乙烯基-N-烷基-羧酸酰胺，包括以下阶段：(a) 将N-乙基羧酸酰胺进行阳极烷氧基化，得到N-α-烷氧乙基羧酸酰胺；(b) 在碱性介质中用烷基卤化物或二烷基硫酸盐烷基化这些N-α-烷氧乙基羧酸酰胺，得到N-α-烷氧乙基-N-烷基羧酸酰胺；(c) 通过加热至约60度至约350度C的温度，从(b)阶段产物中分离出醇。在(a)阶段之后，也可以执行以下阶段代替(b)和(c)阶段：(b.sub.1) 将在(a)阶段获得的N-α-烷氧乙基羧酸酰胺加热至约60度至约600度C，分离出醇，得到N-乙烯基羧酸酰胺；(c.sub.1) 将这些N-乙烯基羧酸酰胺在碱性介质中通过与与(b)阶段相同类型的烷基化剂反应进行烷基化。该过程获得的N-乙烯基-N-烷基-羧酸酰胺是有价值的中间产物，特别适用于制造具有有趣性能的均聚物和共聚物。

  公开号：

  US04322271A1

文献信息

• Process for the preparation of N-.alpha.-alkoxyalkyl-carboxamides, and
  申请人：Hoechst Aktiengesellschaft

  公开号：US04334097A1

  公开（公告）日：1982-06-08

  N-.alpha.-Alkoxyalkyl-carboxamides are prepared by reacting primary or secondary amides of aliphatic, araliphatic or aromatic carboxylic acids, or cyclic carboxamides (lactams) which are not capable of forming an aromatic system, with open-chain .alpha.-halogenoalkyl ethers with at least 3 C atoms per molecule, in the presence of tertiary amines. N,N-Bis-.alpha.-alkoxyalkylcarboxamides can also be obtained from the primary carboxiamides. The reaction products, of which the compounds V and VI: ##STR1## wherein R.sup.4 =C.sub. -C.sub.4 -alkyl and R.sup.5 =CH.sub.3 or C.sub.2 H.sub.5, are new, are intermediates mainly for the preparation of N-alkenyl- or N-vinyl-carboxamides, of which, in turn, the compounds VII are new: ##STR2## The N-alkenyl- or N-vinyl-carboxamides can themselves be processed to give valuable homopolymers and copolymers.

  N-.alpha.-Alkoxyalkyl-羧酰胺是通过将脂肪族、芳基脂肪族或芳香族羧酸的一级或二级酰胺，或者不能形成芳香体系的开链α-卤代烷醚与每个分子至少有3个碳原子的环状羧酰胺（内酰胺）在三级胺存在下反应制备的。N,N-双α-烷氧基烷基羧酰胺也可以从一级羧胺中得到。其中化合物V和VI的反应产物是新的，其中R⁴=C-C⁴-烷基且R⁵=CH₃或C₂H₅，主要用于制备N-烯基或N-乙烯基羧酰胺的中间体，其中化合物VII又是新的。N-烯基或N-乙烯基羧酰胺本身可以加工成有价值的均聚物和共聚物。
• METHOD FOR PRODUCING N-METHYL-N-VINYLACETAMIDE HAVING IMPROVED STABILITY AND POLYMERIZABILITY
  申请人：Showa Denko K.K.

  公开号：EP2239250A1

  公开（公告）日：2010-10-13

  The present invention relates to a method for producing N-methyl-N-vinylacetamide, which comprises a step for controlling the N-1,3-butadienyl-N-methylacetamide content in N-methyl-N-vinylacetamide to 0.01-150 ppm. This method enables production of N-methyl-N-vinylacetamide having a stable quality, which can be controlled in stability and polymerizability as a monomer. N-methyl-N-vinylacetamide produced by the method enables production of an N-methyl-N-vinylacetamide polymer having stable physical properties such as a molecular weight.

  本发明涉及一种生产N-甲基-N-乙烯基乙酰胺的方法，其中包括控制N-1,3-丁二烯基-N-甲基乙酰胺在N-甲基-N-乙烯基乙酰胺中的含量为0.01-150 ppm的步骤。该方法使得能够生产具有稳定质量的N-甲基-N-乙烯基乙酰胺，可以在稳定性和聚合性作为单体中进行控制。通过该方法生产的N-甲基-N-乙烯基乙酰胺能够生产具有稳定物理性质，如分子量的N-甲基-N-乙烯基乙酰胺聚合物。
• COMPOSITION FOR PRODUCING N-VINYL CARBOXYLIC ACID AMIDE
  申请人：SHOWA DENKO K.K.

  公开号：US20220112155A1

  公开（公告）日：2022-04-14

  The present invention relates to a composition for producing an N-vinylcarboxylic acid amide, the composition including (A) an N-(1-alkoxyethyl)carboxylic acid amide and (B) a carboxylic acid amide other than the N-(1-alkoxyethyl)carboxylic acid amide and the N-vinylcarboxylic acid amide, and satisfying the following conditions (1) to (4): (1) the composition has a melting point of 0 to 30° C.; (2) a water content is 0 to 1.00% by mass in a total amount of the composition; (3) a content ratio of the component (A) to the component (B) is 4.0 to 20.0 in terms of a molar ratio; and (4) a 5% by mass aqueous solution of the composition has a pH of 4.0 to 8.0. The present invention also relates to a method for producing an N-vinylcarboxylic acid amide, the method including thermally decomposing or catalytically decomposing the composition for producing an N-vinylcarboxylic acid amide.

  本发明涉及一种用于生产N-乙烯基羧酸酰胺的组合物，该组合物包括（A）N-(1-烷氧基乙基)羧酸酰胺和（B）除N-(1-烷氧基乙基)羧酸酰胺和N-乙烯基羧酸酰胺以外的羧酸酰胺，并满足以下条件（1）至（4）：（1）组合物的熔点为0至30℃；（2）组合物总量中的水含量为0至1.00%质量分数；（3）组分（A）与组分（B）的含量比为摩尔比4.0至20.0；（4）组合物的5%质量分数水溶液的pH值为4.0至8.0。本发明还涉及一种生产N-乙烯基羧酸酰胺的方法，该方法包括热分解或催化分解上述用于生产N-乙烯基羧酸酰胺的组合物。
• METHOD OF PRODUCING N-VINYLCARBOXYLIC ACID AMIDE
  申请人：SHOWA DENKO K.K.

  公开号：US20210214302A1

  公开（公告）日：2021-07-15

  A method for producing an N-vinylcarboxylic acid amide is provided, the method focusing on unsaturated aldehydes that are contained as impurities generated during a reaction. The method for producing an N-vinylcarboxylic acid amide includes a step for controlling the contained amount of unsaturated aldehydes in the N-vinylcarboxylic acid amide to be not more than 20 mass ppm.

  提供了一种生产N-乙烯基羧酸酰胺的方法，该方法侧重于在反应过程中生成的不饱和醛作为杂质。生产N-乙烯基羧酸酰胺的方法包括一步，控制N-乙烯基羧酸酰胺中含有的不饱和醛的含量不超过20质量ppm。
• Process for preparing n-vinyl amides
  申请人：Air Products and Chemicals, Inc.

  公开号：US04942259A1

  公开（公告）日：1990-07-17

  N-vinyl amides having the general structural formula: CH.sub.2 .dbd.CH--NHCOR.sup.1 wherein R.sup.1 is hydrogen, a C.sub.1 to C.sub.6 alkyl group or C.sub.6 -C.sub.9 aryl or substituted aryl group, are formed by cracking carboxylic acid amides having the general structure formula: ##STR1## wherein R.sup.1 is as described above, and R.sup.2 is a C.sub.1 to C.sub.9 alkoxy, carboxy or carboxamide group. Said carboxylic acid amides are cracked by heating, to a temperature of about 150.degree.-350.degree. C., in the presence of a porous, hydrogen-abstracting catalyst.

  具有一般结构式CH.sub.2.dbd.CH--NHCOR.sup.1的N-乙烯基酰胺，其中R.sup.1为氢、C.sub.1至C.sub.6烷基或C.sub.6-C.sub.9芳基或取代芳基，是通过加热裂解具有以下一般结构式的羧酸酰胺形成的：##STR1## 其中R.sup.1如上所述，而R.sup.2是C.sub.1至C.sub.9烷氧基、羧基或羧酰胺基团。在多孔的氢抽提催化剂的存在下，将该羧酸酰胺加热至约150℃至350℃的温度，即可裂解。