3-octyl-5,5-diphenylimidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-octyl-5,5-diphenylimidazolidine-2,4-dione
• 化学式: C₂₃H₂₈N₂O₂
• 分子量: 364.488
• InChiKey: JQWCZAYQDXLFEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 potassium carbonate 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 3-octyl-5,5-diphenylimidazolidine-2,4-dione
  参考文献：
  名称：

  3-Alkyl-(5,5′-diphenyl)imidazolidinediones as new cannabinoid receptor ligands

  摘要：

  Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [H-3]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00353-4

文献信息

• 3-Alkyl-(5,5′-diphenyl)imidazolidinediones as new cannabinoid receptor ligands
  作者：Martial Kanyonyo、Sophie J. Govaerts、Emmanuel Hermans、Jacques H. Poupaert、Didier M. Lambert

  DOI：10.1016/s0960-894x(99)00353-4

  日期：1999.8

  Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [H-3]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists. (C) 1999 Elsevier Science Ltd. All rights reserved.