2-phenyl monomethyl glutarate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-phenyl monomethyl glutarate
• 英文别名: 5-Methoxy-5-oxo-4-phenylpentanoic acid
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: YFPCPKOUODSSTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-phenyl monomethyl glutarate 、 二丁基二氯化锡 在 三乙胺 作用下， 以85%的产率得到dibutyltin bis(2-phenylmonomethylglutarate)
  参考文献：
  名称：

  Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate

  摘要：

  A novel series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, H-1, C-13, Sn-119 NMR, Sn-119m Mossbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.08.006
• 作为产物：
  描述：

  甲醇 、 2-苯基戊二酸酐 反应 10.0h， 以75%的产率得到2-phenyl monomethyl glutarate
  参考文献：
  名称：

  Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate

  摘要：

  A novel series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, H-1, C-13, Sn-119 NMR, Sn-119m Mossbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2014.08.006

文献信息

• US6294577B1
  申请人：——

  公开号：US6294577B1

  公开（公告）日：2001-09-25
• Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate
  作者：Wajid Rehman、Amin Badshah、Fazal Rahim、Musa Kaleem Baloch、Hameed Ullah、Obaid-Ur-Rahman Abid、Mohsan Nawaz、Isfahan Tauseef

  DOI：10.1016/j.ica.2014.08.006

  日期：2014.11

  A novel series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, H-1, C-13, Sn-119 NMR, Sn-119m Mossbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity. (C) 2014 Elsevier B.V. All rights reserved.