6-丙氧基哒嗪-3-胺 | 90008-50-7

• 物质功能分类: 医药中间体 - 杂环化合物 - 哒嗪类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 6-丙氧基哒嗪-3-胺
• 中文别名: 6-丙氧基-3-氨基吡嗪
• 英文名称: 3-amino-6-propoxypyridazine
• 英文别名: 6-propoxypyridazin-3-amine；6-propoxy-pyridazin-3-ylamine；3-Amino-6-propyloxy-pyridazin
• CAS: 90008-50-7
• 化学式: C₇H₁₁N₃O
• 分子量: 153.184
• InChiKey: YXEDABZQSZKQKZ-UHFFFAOYSA-N

物化性质

• 沸点：
  355.0±22.0 °C(Predicted)
• 密度：
  1.133±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  2-8°C

反应信息

• 作为反应物：
  描述：

  6-丙氧基哒嗪-3-胺 在 N-碘代丁二酰亚胺 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 4.0h， 生成 3-iodo-2-[4-(2-methoxyethoxy)phenyl]-6-propoxyimidazo[1,2-b]pyridazine
  参考文献：
  名称：

  2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

  摘要：

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.096
• 作为产物：
  描述：

  丙醇 、 3-氨基-6-氯哒嗪 在 sodium 作用下， 生成 6-丙氧基哒嗪-3-胺
  参考文献：
  名称：

  2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus

  摘要：

  A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30 nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.05.096

文献信息

• [EN] CONTROL OF PARASITES IN ANIMALS BY THE USE OF IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES<br/>[FR] LUTTE CONTRE LES PARASITES CHEZ DES ANIMAUX, A L'AIDE DE DERIVES D'IMIDAZO[1,2-B]PYRIDAZINE
  申请人：SCHERING PLOUGH LTD

  公开号：WO2005066177A1

  公开（公告）日：2005-07-21

  Novel imidazo[1,2-b]pyridazine compounds useful for controlling parasites in animals and methods of treatment of parasite infestation in animals using the compounds are disclosed. Formula (I).

  新型咪唑并[1,2-b]吡啶嗪化合物，用于控制动物体内寄生虫，并公开了使用这些化合物治疗动物寄生虫感染的方法。公式（I）。
• A revision of the alcoholysis and alkanethiolysis of 3-amino-6-chloropyridazine
  作者：Bert U. W. Maes、Guy L. F. Lemière、Roger Dommisse、Achiel Haemers

  DOI：10.1002/jhet.5570380530

  日期：2001.9

  The synthesis of 3-amino-6-alkoxy- and 3-amino-6-alkylthiopyridazines via nucleophilic aromatic substitution on 3-amino-6-chloropyridazine is described. In contrast to literature reports, no pressure tube is required to perform these reactions.

  描述了通过在3-氨基-6-氯哒嗪上的亲核芳族取代合成3-氨基-6-烷氧基-和3-氨基-6-烷基硫代哒嗪。与文献报道相反，不需要压力管来进行这些反应。
• N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. III. Pyrido- and Pyridazo-Fused [1,2,4,6]Thiatriazine Dioxides
  作者：Teresa Cablewski、Erin J. Carter、Craig L. Francis、Andris J. Liepa、Michael V. Perkins

  DOI：10.1071/ch06367

  日期：——

  N,N-Dialkyl-N′-chlorosulfonylchloroformamidines 1 reacted with 2-aminopyridines 2 to give novel pyrido[1,2-b][1,2,4,6]thiatriazine dioxides 3 and pyrido[2,1-c][1,2,4,6]thiatriazine dioxides 4. Reaction of 1 with 3-aminopyridazines 5 afforded pyridazo[3,2-c][1,2,4,6]thiatriazine dioxides 6 and a pyridazo[2,3-b][1,2,4,6]thiatriazine dioxide 7. The compounds 6 and 7 are derivatives of new ring systems.

  N,N-二烷基-N′-氯磺酰基氯甲酰胺 1 与 2-氨基吡啶 2 反应，得到新型吡啶并[1,2-b][1,2,4,6]噻三嗪二恶英 3 和吡啶并[2,1-c][1,2,4,6]噻三嗪二恶英 4。将 1 与 3-氨基哒嗪 5 反应，可得到哒嗪并[3,2-c][1,2,4,6]噻嗪二恶英 6 和哒嗪并[2,3-b][1,2,4,6]噻嗪二恶英 7。化合物 6 和 7 是新环系的衍生物。
• Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives
  申请人：Winzenberg N. Kevin

  公开号：US20050182059A1

  公开（公告）日：2005-08-18

  Novel imidazo[1,2-b]pyridazine compounds useful for controlling parasites in animals and methods of treatment of parasite infestation in animals using the compounds are disclosed.

  本发明揭示了一种用于控制动物寄生虫的新型咪唑并[1,2-b]吡啶嘧啶化合物，以及使用该化合物治疗动物寄生虫感染的方法。
• Syntheses, pharmacological evaluation and molecular modelling of substituted 6-alkoxyimidazo[1,2-b]pyridazines as new ligands for the benzodiazepine receptor
  作者：PW Harrison、GB Barlin、LP Davies、SJ Ireland、P Mátyus、MG Wong

  DOI：10.1016/0223-5234(96)85873-9

  日期：1996.1

  A series of 2,3-disubstituted-6-alkoxyimidazo[1,2-b] has been synthesized and evaluated for in vitro affinity for the benzodiazepine receptor (BZR). 3-(Benzamidomethyl or substituted benzamidomethyl)-6-methoxy-2-(3,4-methylenedioxyphenyl)imidazo[1,2-b]pyridazines were found to be the most potent BZR ligands (eg, 4a, IC50 7 nM; 4e, IC50 14 nM; 4v, IC50 8 nM). Imidazo[1,2-b]pyridazines unsubstituted in the 3-position, or containing builder alkoxy groups in the 6-position, were found to bind less strongly to the BZR. Selected compounds from the series were identified from in vitro GABA-shift experiments as BZR agonists. Molecular modelling has been employed to identify the common pharmacophoric points of lipophilic and hydrogen bonding, ligand-receptor interaction and areas of steric hindrance for these substituted imidazo[1,2-b]pyridazines at the BZR.