环(丙氨酸-苯丙氨酸)二肽 | 14474-78-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 环(丙氨酸-苯丙氨酸)二肽
• 英文名称: cyclo-L-alanyl-D-phenylalanyl
• 英文别名: cyclo-(Phe-Ala)；cyclo(Ala-Phe)；3-benzyl-6-methyl-piperazine-2,5-dione；3-Benzyl-6-methyl-piperazin-2,5-dion；3-Benzyl-6-methyl-2,5-dioxo-piperazin；3-Benzyl-6-methyl-2,5-piperazinedione；3-benzyl-6-methylpiperazine-2,5-dione
• CAS: 14474-78-3
• 化学式: C₁₂H₁₄N₂O₂
• 分子量: 218.255
• InChiKey: CNXWPOWVDIUTPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-benzyl-6-methyl-1,6-dihydro-pyrazine-2,5-dione 、 环(丙氨酸-苯丙氨酸)二肽 在 盐酸 作用下， 生成 DL-丙氨酸
  参考文献：
  名称：

  Bergmann; Miekeley, Justus Liebigs Annalen der Chemie, 1927, vol. 458, p. 66

  摘要：

  DOI：
• 作为产物：
  描述：

  D-苯丙氨酸甲酯盐酸盐 在 甲酸 、 N,N'-二环己基碳二亚胺 作用下， 以 甲苯 、 仲丁醇 为溶剂， 反应 2.0h， 生成 环(丙氨酸-苯丙氨酸)二肽
  参考文献：
  名称：

  Conformational effects in reversed-phase liquid chromatographic separation of diastereomers of cyclic dipeptides

  摘要：

  The capacity factors, k', of 11 cyclic dipeptides (X-Y) including diastereomers have been determined on an RP-HPLC column in 30% and 50% methanol and 10%, 30%, and 50% acetonitrile solutions. These factors are roughly correlated with hydrophobic parameters, such as octanol-water partition coefficients estimated and k' values for alcohols. For a pair of diastereomers of cyclic (L-X-L-Phe) and (L-X-D-Phe) derivatives k'LL is larger than k'LD, and for cyclic (D-Ala-L-Trp) and (L-Ala-L-Trp) k'LL is smaller than k'DL, particularly in highly aqueous solutions. These elution orders can be well predicted by the holistic molecular surface area approach which takes into account the folded structures of cyclic dipeptides. The present results will be useful for prediction of the log k' values of larger peptides and the hydrophobicity and related properties of peptides.

  DOI：

  10.1021/ac00062a010

文献信息

• One-Year Follow-Up of Medication Management Capacity in Highly Functioning Older Adults
  作者：H. K. Edelberg、E. Shallenberger、J. M. Hausdorff、J. Y. Wei

  DOI：10.1093/gerona/55.10.m550

  日期：2000.10.1

  Background, We tested the hypothesis that impairment in the ability to take medication independently predicts early functional decline.Methods. A 12-month, prospective cohort study was performed at two continuing-care retirement facilities using the Drug Regimen Unassisted Grading Scale (DRUGS). This geriatric screening tool utilizes a stepwise progression of four tasks: (i) identification, (ii) access, (iii) dosage, and (iv) timing.Results, Forty-seven (86%) of the eligible participants completed the 12-month follow-up assessment; three were transferred to skilled nursing facilities. The mean age at study entry was 84.2 i: 5.1 years; 72% of the participants were women, and 68% were college educated. At 12 months there was a decline in the Mini-Mental State Examination (MMSE) score(p = .029), an increase in the timed "Up and Go" test(p = .023), and a decline in the DRUGS score (p = .029). Nine (18%) of the participants resided in assisted- versus independent-living situations compared with three par participants (5%) at study entry (p = .031). Both 12-month DRUGS score and 12-month self-reported medication manage ment capacity were associated with 12-month MMSE (p = .0001 and p = .019, respectively). Baseline DRUGS score was associated with 12-month MMSE and Geriatric Depression Scale scores (p = .0002 and p = .002, respectively). Both baseline DRUGS score and self-reported medication management capacity were also associated with residence in assisted-living communities at 6 months (p = .029 and p = .040, respectively). MMSE was not associated with any of the clinical outcomes.Conclusions. The DRUGS tool may predict functional decline in highly functioning older adults.
• Schoeller,W., Diss. <Berlin 1906>, S. 39, 44
  作者：Schoeller,W.

  DOI：——

  日期：——
• Abderhalden, Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1923, vol. 128, p. 123
  作者：Abderhalden

  DOI：——

  日期：——
• Abderhalden; Funk, Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1907, vol. 53, p. 28
  作者：Abderhalden、Funk

  DOI：——

  日期：——
• Bergmann; Miekeley, Justus Liebigs Annalen der Chemie, 1927, vol. 458, p. 66
  作者：Bergmann、Miekeley

  DOI：——

  日期：——

表征谱图