pseudo-porphobilinogen | 144929-06-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: pseudo-porphobilinogen
• 英文别名: Ohskccylcdxiji-uhfffaoysa-；3-[4-amino-5-(2-carboxyethyl)-1H-pyrrol-3-yl]propanoic acid
• CAS: 144929-06-6
• 化学式: C₁₀H₁₄N₂O₄
• 分子量: 226.232
• InChiKey: OHSKCCYLCDXIJI-UHFFFAOYSA-N

物化性质

• 沸点：
  519.8±45.0 °C(Predicted)
• 密度：
  1.432±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-氨基乙酰丙酸盐酸盐 在 sodium hydroxide 作用下， 反应 4.0h， 生成 pseudo-porphobilinogen 、 3,6-二氢-2,5-吡唑啉胆酸
  参考文献：
  名称：

  The nonenzymatic cyclic dimerisation of 5-aminolevulinic acid

  摘要：

  The nonenzymatic cyclic dimerisation of 5-aminolevulinic acid (5-ALA) leads to the formation of a pyrazine (3) and, under some circumstances, pseudo-porphobilinogen (1). On the other hand, the enzyme-catalysed process leads to porphobilinogen (PBG). The products of the former reaction were identified from their NMR spectra and mechanisms for their formation are proposed.

  DOI：

  10.1016/s0040-4020(01)80465-8

文献信息

• The nonenzymatic cyclic dimerisation of 5-aminolevulinic acid
  作者：Anthony R Butler、Sharon George

  DOI：10.1016/s0040-4020(01)80465-8

  日期：1992.1

  The nonenzymatic cyclic dimerisation of 5-aminolevulinic acid (5-ALA) leads to the formation of a pyrazine (3) and, under some circumstances, pseudo-porphobilinogen (1). On the other hand, the enzyme-catalysed process leads to porphobilinogen (PBG). The products of the former reaction were identified from their NMR spectra and mechanisms for their formation are proposed.