[manganese(III)(C19H6N2(C6F5)3(SO3H)2] | 443927-55-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [manganese(III)(C19H6N2(C6F5)3(SO3H)2]
• 英文别名: 5,10,15-tris(pentafluorophenyl)-2,17-bis(sulfonic acid)corrolatomanganese(III)；2,17-bis(sulfonato)-5,10,15-tris(pentafluorophenyl)-corrolato manganese(III)
• CAS: 443927-55-7
• 化学式: C₃₇H₈F₁₅MnN₄O₆S₂
• 分子量: 1008.54
• InChiKey: NKVXRNMODVKDAK-QDWXPRJESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [manganese(III)(C19H6N2(C6F5)3(SO3H)2] 在 亚碘酰苯 作用下， 以 not given 为溶剂， 生成
  参考文献：
  名称：

  白蛋白共轭 Corrole 金属配合物：极其简单但非常有效的仿生氧化系统

  摘要：

  一个极其简单的仿生氧化系统，由混合两亲性corroles的金属配合物与血清白蛋白组成，利用过氧化氢进行高达74% ee的不对称磺化氧化。与白蛋白结合的锰也显示出类似过氧化氢酶的活性，机理证据表明，氧化剂配位的锰 (III) 作为主要反应中间体。

  DOI：

  10.1021/ja045372c
• 作为产物：
  描述：

  以 水 为溶剂， 生成 [manganese(III)(C19H6N2(C6F5)3(SO3H)2]
  参考文献：
  名称：

  铁和锰的腐蚀剂是过氧亚硝酸盐分解的有效催化剂。

  摘要：

  DOI：

  10.1002/anie.200601399
• 作为试剂：
  描述：

  过氧亚硝酸 在 [manganese(III)(C19H6N2(C6F5)3(SO3H)2] sodium hydroxide 、 phosphate buffer 作用下， 以 水 为溶剂， 生成 亚硝酸
  参考文献：
  名称：

  铁和锰的腐蚀剂是过氧亚硝酸盐分解的有效催化剂。

  摘要：

  DOI：

  10.1002/anie.200601399

文献信息

• Selective Substitution of Corroles:  Nitration, Hydroformylation, and Chlorosulfonation
  作者：Irena Saltsman、Atif Mahammed、Israel Goldberg、Elena Tkachenko、Mark Botoshansky、Zeev Gross

  DOI：10.1021/ja025851g

  日期：2002.6.1

  work demonstrates the feasibility and power of electrophilic substitution on the peripheral carbon atoms of triarylcorroles as a synthetic tool to new derivatives. The large difference in the reactivity of the various carbon atoms on the macrocycle was shown to be of electronic rather than steric origin. A careful choice of reagents and a delicate control of reaction conditions allowed the selective

  这项工作证明了在三芳基可罗的外围碳原子上亲电取代作为合成新衍生物的工具的可行性和能力。大环上各种碳原子反应性的巨大差异被证明是电子的而不是空间的。仔细选择试剂和精细控制反应条件允许选择性合成新衍生物，在所有这些衍生物中，仅在大环的直接连接的吡咯环中选择性地发生取代。这已通过各种产品的 X 射线晶体学及其核磁共振谱的详细分析得到证实。
• Neuroprotection against superoxide anion radical by metallocorroles in cellular and murine models of optic neuropathy
  作者：Akiyasu Kanamori、Maria-Magdalena Catrinescu、Atif Mahammed、Zeev Gross、Leonard A. Levin

  DOI：10.1111/j.1471-4159.2010.06781.x

  日期：2010.7

  J. Neurochem. (2010) 114, 488–498.AbstractCorroles are tetrapyrrolic macrocycles that have come under increased attention because of their unique capabilities for oxidation catalysis, reduction catalysis, and biomedical applications. Corrole‐metal complexes (metallocorroles) can decompose certain reactive oxygen species (ROS), similar to metalloporphyrins. We investigated whether Fe‐, Mn‐, and Ga‐corroles have neuroprotective effects on neurons and correlated this with superoxide scavenging activity in vitro and in vivo. Apoptosis was induced in retinal ganglion cell‐5 neuronal precursor cells by serum deprivation. Cell death was measured with sodium 3′‐[1‐[(phenylamino)‐carbonyl]‐3,4‐tetrazolium]‐bis (4‐methoxy‐6‐nitro) benzene‐sulfonic acid hydrate and calcein‐AM/propidium iodide assays. Fe‐ and Mn‐corroles, but not the non‐redox‐active Ga‐corrole used as control, reduced RGC‐5 cell death after serum deprivation. Serum deprivation caused increased levels of intracellular superoxide, detected by an increase in the fluorescence intensity of 2‐hydroxyethidium, and this was blocked by Fe‐ and Mn‐corroles, but not Ga‐corrole. In vivo real‐time confocal imaging of retinas after optic nerve transection assessed the superoxide production within individual rat retinal ganglion cells. Fe‐ and Mn‐corroles, but not Ga‐corrole, scavenged neuronal superoxide in vivo. Given that the neuroprotective activity of metallocorroles correlated with superoxide scavenging activity, Fe‐ and Mn‐corroles could be candidate drugs for delaying neuronal death after axonal injury in optic neuropathies, such as glaucoma.