(S)-3-(4-{[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphanyloxy}-phenyl)-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester | 855429-61-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-3-(4-{[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphanyloxy}-phenyl)-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester
• CAS: 855429-61-7
• 化学式: C₃₅H₅₁N₆O₁₁PS
• 分子量: 794.863
• InChiKey: CXTPZPSORQRDFI-KTNJOBELSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.23
• 重原子数：
  54.0
• 可旋转键数：
  15.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  222.24
• 氢给体数：
  2.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  (S)-3-(4-{[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphanyloxy}-phenyl)-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester 在 叔丁基过氧化氢 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 (S)-2-Amino-3-(4-{[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphoryloxy}-phenyl)-propionic acid; compound with trifluoro-acetic acid
  参考文献：
  名称：

  DESIGN OF NEW MONONUCLEOTIDE PRODRUGS: ARYL (SATE) PHOSPHOTRIESTER DERIVATIVES

  摘要：

  Synthesis, biological activities and decomposition kinetics of novel phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-tButyl-2-thioethyl (tBuSATE) group and L-tyrosinyl residues are reported. All the derivatives appeared to be potent inhibitors of HIV-1 replication in various cell culture experiments. The proposed decomposition process of these mixed phosphotriesters may involve successively an esterase and then a phosphodiesterase activation.

  DOI：

  10.1081/ncn-100002302
• 作为产物：
  描述：

  S-pivaloyl-2-thioethyl di(N,N-diisopropylamino)phosphoramidite 在 四氮唑 、 3 A molecular sieve 、 二异丙胺 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 (S)-3-(4-{[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-[2-(2,2-dimethyl-propionylsulfanyl)-ethoxy]-phosphanyloxy}-phenyl)-2-tert-butoxycarbonylamino-propionic acid tert-butyl ester
  参考文献：
  名称：

  S-Acyl-2-thioethyl Aryl Phosphotriester Derivatives as Mononucleotide Prodrugs

  摘要：

  The synthesis and biological activities of phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a phenyl group or L-tyrosinyl residues are reported. The target compounds were obtained via either P-V or p(III) chemistry from the appropriate aryl precursors. All the derivatives were evaluated for their in vitro anti-HIV activity, and they appeared to be potent inhibitors of HIV-1 replication in various cell culture experiments, with EC50 values between the micro- and nanomolar range. Furthermore, compounds incorporating an amino-and/or acid-substituted tyrosinyl residue demonstrated significant anti-HIV effects in thymidine kinase-deficient (TK-) cells showing their ability to act as mononucleotide prodrugs. The proposed decomposition process of these mixed mononucleoside aryl phosphotriesters may involve esterase activation followed by phosphodiesterase hydrolysis.

  DOI：

  10.1021/jm000996o

文献信息

• Rational design of a new series of mixed anti-HIV pronucleotides
  作者：Nathalie Schlienger、Thierry Beltran、Christian Périgaud、Isabelle Lefebvre、Alain Pompon、Anne-Marie Aubertin、Gilles Gosselin、Jean-Louis Imbach

  DOI：10.1016/s0960-894x(98)00535-6

  日期：1998.11

  MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of hew pronucleotide series, (C) 1998 Elsevier Science Ltd. All rights reserved.