4,4'-dichloro-3,5,3',5'-tetramethyl-2,2'-sulfanediyl-di-phenol | 97646-14-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4,4'-dichloro-3,5,3',5'-tetramethyl-2,2'-sulfanediyl-di-phenol
• 英文别名: 4,4'-Dichlor-3,5,3',5'-tetramethyl-2,2'-sulfandiyl-di-phenol；Bis-(3-chlor-6-hydroxy-2.4-dimethyl-phenyl)-sulfid；3.3'-Dichlor-6.6'-dioxy-2.4.2'.4'-tetramethyl-diphenylsulfid；4-Chloro-2-(3-chloro-6-hydroxy-2,4-dimethylphenyl)sulfanyl-3,5-dimethylphenol
• CAS: 97646-14-5
• 化学式: C₁₆H₁₆Cl₂O₂S
• 分子量: 343.274
• InChiKey: KUXLZVPJUMXGIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  65.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4,4'-dichloro-3,5,3',5'-tetramethyl-2,2'-sulfanediyl-di-phenol 在 溴 、 溶剂黄146 作用下， 生成 6,6'-dibromo-4,4'-dichloro-3,5,3',5'-tetramethyl-2,2'-sulfanediyl-di-phenol
  参考文献：
  名称：

  Lesser; Gad, Chemische Berichte, 1923, vol. 56, p. 968

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯-3,5-二甲基苯酚 在 氯仿 、 二氯化硫 作用下， 生成 4,4'-dichloro-3,5,3',5'-tetramethyl-2,2'-sulfanediyl-di-phenol
  参考文献：
  名称：

  Lesser; Gad, Chemische Berichte, 1923, vol. 56, p. 968

  摘要：

  DOI：

文献信息

• Chemical entities that kill senescent cells for use in treating age-related disease
  申请人：Unity Biotechnology, Inc.

  公开号：US10195213B2

  公开（公告）日：2019-02-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.

  本文公开的化合物可有效治疗与衰老有关的各种疾病状态。所公开的化合物可用于消除衰老细胞以治疗疾病。化合物的给药方式包括单次给药和循环给药。
• Introduction of Mannich Groups into Some Aromatic Phenolic Compounds^1a,1b
  作者：Jacob R. Meadow、E. Emmet Reid

  DOI：10.1021/ja01642a034

  日期：1954.7
• GAIN-OF-FUNCTION BCL-2 INHIBITORS
  申请人：HOCKENBERY David

  公开号：US20120252839A1

  公开（公告）日：2012-10-04

  Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-x L , and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x L . Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-x L , and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-x L . Several scaffolds of active compounds are described.
• COMPOUNDS AND THERAPEUTIC USES
  申请人：Unity Biotechnology, Inc.

  公开号：US20170281649A1

  公开（公告）日：2017-10-05

  Disclosed herein are compounds that are effective for treatment of various disease states associated with senescence. The disclosed compounds can be used to eliminate senescent cells for disease treatment. The dosing of the compounds includes both single administration and regimens of cycling dosages.
• US8865901B2
  申请人：——

  公开号：US8865901B2

  公开（公告）日：2014-10-21