Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
OPTICAL FIBRE COATING WITH NON-RADIATION-CURABLE ACRYLIC HARD-SOFT BLOCK COPOLYMER
申请人:Corning Inc.
公开号:EP3092277A2
公开(公告)日:2016-11-16
THERAPEUTIC COMPOSITIONS
申请人:Tzianabos Arthur
公开号:US20110052673A1
公开(公告)日:2011-03-03
Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
US20140341524A1
申请人:——
公开号:US20140341524A1
公开(公告)日:2014-11-20
METHOD FOR PRODUCING RESIN COMPOSITION AND RESIN COMPOSITION
申请人:CANON KABUSHIKI KAISHA
公开号:US20140323659A1
公开(公告)日:2014-10-30
A method for producing a resin composition, comprising the step of: subjecting a radical copolymerization of a first radical polymerizable monomer which is free from any crystalline molecular chain, and a second radical polymerizable monomer having a crystalline molecular chain, in the presence of a radical polymerization initiator, wherein the second radical polymerizable monomer is the following compound, and
(wherein R
1
denotes a hydrogen atom or a methyl group, and R
2
denotes an alkyl group having at least 17 carbon atoms) the first radical polymerizable monomer has a particular reactivity ratio.