N-[2-(4-羟基-3-甲氧基苯基)乙基]甲酰胺 | 282721-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: N-[2-(4-羟基-3-甲氧基苯基)乙基]甲酰胺
• 英文名称: N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]formamide
• 英文别名: N-Formyl-3-methoxy-4-hydroxy-phenaethylamin；N2-(3-methoxy-4-hydroxyphenyl)ethylformamide
• CAS: 282721-32-8
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: VLUDIKIXDYJLGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[2-(4-羟基-3-甲氧基苯基)乙基]甲酰胺 在 sodium methylate 、 三乙胺 、 三氯氧磷 作用下， 生成 4-(2-isocyanoethyl)-2-methoxy-1-(prop-2-ynyloxy)benzene
  参考文献：
  名称：

  N-Sulfonyl Amino Acid Amides, a Novel Class of Compounds with Fungicidal Activity [1]

  摘要：

  已经设计和制备了新型的疫霉菌杀菌剂。这些N-磺酰氨基酸酰胺的合成方法已经概述。生物测定表明它们对重要植物病害如晚疫病菌（番茄和马铃薯晚疫病）和葡萄霜霉病（葡萄霜霉病）具有很高的效力。结构活性关系研究也已讨论。

  DOI：

  10.2533/000942903777678542
• 作为产物：
  描述：

  N-benzyloxycarbonyl-3,4-dihydroxyphenylethylamine 在 palladium on activated charcoal 氢气 、 碳酸氢钠 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 21.0h， 生成 N-[2-(4-羟基-3-甲氧基苯基)乙基]甲酰胺
  参考文献：
  名称：

  Casagrande; Santangelo; Saini, Arzneimittel-Forschung/Drug Research, 1986, vol. 36, # 2 A, p. 291 - 303

  摘要：

  DOI：

文献信息

• Phenyl-propargylether derivatives
  申请人：Syngenta Crop Protection, Inc.

  公开号：US06683211B1

  公开（公告）日：2004-01-27

  The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl, R9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is halogen, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkenylthio; optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenylsulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkenylsulfonyl or optionally substituted alkynylsulfonyl. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

  该发明涉及一般式I的苯基-丙炔醚衍生物，包括其光学异构体和这些异构体的混合物，其中 R1为氢、烷基、环烷基或可选择取代的芳基， R2和R3分别独立为氢或烷基， R4为烷基、烯基或炔基， R5、R6、R7和R8分别独立为氢或烷基， R9为氢、可选择取代的烷基、可选择取代的烯基或可选择取代的炔基， R10为可选择取代的芳基或可选择取代的杂环芳基，以及 Z为卤素、可选择取代的芳氧基、可选择取代的烷氧基、可选择取代的烯氧基、可选择取代的炔氧基、可选择取代的芳硫基、可选择取代的烷硫基、可选择取代的烯硫基、可选择取代的炔硫基、可选择取代的烷亚砜基、可选择取代的烯亚砜基、可选择取代的炔亚砜基、可选择取代的烷砜基、可选择取代的烯砜基或可选择取代的炔砜基。这些化合物具有有用的植物保护性能，并可有利地用于农业实践中，用于控制或预防植物受植物病原微生物，特别是真菌的侵害。
• Propargylether derivatives
  申请人：Syngenta Participations AG

  公开号：US06469005B1

  公开（公告）日：2002-10-22

  Propargylether derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl and R9 is a group R10 is optionally substituted aryl or optionally substituted heteroaryl, R11 is hydrogen or optionally substituted alkyl, alkenyl or alkynyl, Z is hydrogen —CO—R16, —COOR16, —CO—COOR16 or —CONR16R17, R12 is hydrogen, or optionally substituted alkyl, alkenyl or alkynyl, R13 is hydrogen or alkyl, R14 is hydrogen, alkyl, cycloalkyl or cycloalkyl-alkyl, R15 is alkyl, alkenyl, alkynyl, optionally substituted aryl or optionally substituted aryl-alkyl, and R16 and R17 are independently of each other hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl, have been found to be useful for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi. The invention relates the novel compounds and also to the preparation thereof and to the use of the compounds for plant protection, and to compositions suitable for applying the novel compounds in agricultural techniques.

  式I的Propargylether衍生物包括其光学异构体和这些异构体的混合物，其中R1是氢，烷基，环烷基或可选择取代的芳基，R2和R3分别独立地是氢或烷基，R4是烷基，烯基或炔基，R5、R6、R7和R8分别独立地是氢或烷基，R9是基团，R10是可选择取代的芳基或可选择取代的杂环芳基，R11是氢或可选择取代的烷基，烯基或炔基，Z是氢，-CO-R16，-COOR16，-CO-COOR16或-CONR16R17，R12是氢或可选择取代的烷基，烯基或炔基，R13是氢或烷基，R14是氢，烷基，环烷基或环烷基-烷基，R15是烷基，烯基，炔基，可选择取代的芳基或可选择取代的芳基-烷基，R16和R17独立地是氢，可选择取代的烷基，可选择取代的环烷基，可选择取代的芳基或可选择取代的杂环芳基，已被发现对控制或预防植物受植物病原微生物，尤其是真菌的侵害具有有用性。该发明涉及新颖的化合物，以及其制备和用于植物保护的化合物的用途，以及适用于在农业技术中应用新化合物的组合物。
• PHARMACEUTICAL COMPOUNDS
  申请人：Duffield Andrew John

  公开号：US20100087475A1

  公开（公告）日：2010-04-08

  This application describes substituted 1,3,4,6,7,11b-hexahydro-benzo(a)quinolizine compounds, pharmaceutical compositions containing them, processes for making them and their therapeutic methods.

  该应用程序描述了取代的1,3,4,6,7,11b-六氢苯并(a)喹啉化合物，含有它们的药物组合物，制备它们的方法以及它们的治疗方法。
• &agr;-sulfenimino acid derivatives
  申请人：Syngenta Crop Protection, Inc.

  公开号：US06479550B1

  公开（公告）日：2002-11-12

  &agr;-Sulfenimino acid derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein A is cycloalkyl, cycloalkenyl, aryl or heteroaryl, each optionally substituted, B is a direct bond or optionally substituted alkylene, E is hydrogen or optionally substituted aryl, R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl, each optionally substituted, and T is NH or oxygen, have been found to be useful for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi. The invention relates the novel compounds and also to the preparation thereof and to the use of the compounds for plant protection, and to compositions suitable for applying the novel compounds in agricultural techniques.

  公式I中的&agr;-Sulfenimino酸衍生物，包括其光学异构体和混合物，其中A是环烷基，环烯基，芳基或杂环芳基，每个都可以选择性地取代，B是直接键或选择性取代的烷基，E是氢或选择性取代的芳基，R是氢，烷基，烯基，炔基，环烷基，环烷基烷基，芳基或芳基烷基，每个都可以选择性地取代，T是NH或氧。已经发现这些化合物对于控制或预防植物被植物病原微生物，特别是真菌的侵染非常有用。本发明涉及新化合物的制备及其使用以保护植物，并涉及适用于在农业技术中应用新化合物的组合物。
• Novel n-p-propargyloxyphenethyl-thioacetic acid amides
  申请人：——

  公开号：US20040127739A1

  公开（公告）日：2004-07-01

  The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R 1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R 2 and R 3 are each independently hydrogen or alkyl, R 4 is alkyl, alkenyl or alkynyl, R 5 , R 6 , R 7 and R 8 are each independently hydrogen or alkyl, R 9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R 10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is hydroxy, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenysulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkenylsulfonyl, optionally substituted alkynylsulfonyl or a group —O—CO—R 11 , —O—CO—O—R 11 or —O—CO—CO—O—R 11 wherein R 11 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi. 1

  本发明涉及一般式（I）的N-丙炔氧基-苯乙硫酸酰胺衍生物，包括其光学异构体和混合物，其中R1是氢、烷基、环烷基或可选取代芳基，R2和R3各自独立地是氢或烷基，R4是烷基、烯基或炔基，R5、R6、R7和R8各自独立地是氢或烷基，R9是氢、可选取代烷基、可选取代烯基或可选取代炔基，R10是可选取代芳基或可选取代杂环芳基，Z是羟基、可选取代芳氧基、可选取代烷氧基、可选取代炔基氧基、可选取代芳硫基、可选取代烷硫基、可选取代炔基硫基、可选取代烷基亚砜基、可选取代烯基亚砜基、可选取代炔基亚砜基、可选取代烷基磺酰基、可选取代烯基磺酰基、可选取代炔基磺酰基或基团—O—CO—R11，—O—CO—O—R11或—O—CO—CO—O—R11，其中R11是氢、可选取代烷基、可选取代环烷基、可选取代芳基或可选取代杂环芳基。这些化合物具有有用的植物保护特性，并可优势地用于农业实践中控制或预防植物受植物病原微生物（尤其是真菌）侵害。