2,3-dihydro-1H-indene-5,6-diol | 3598-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2,3-dihydro-1H-indene-5,6-diol
• 英文别名: 5,6-dihydroxyindan；4,5-Trimethylen-brenzcatechin
• CAS: 3598-20-7
• 化学式: C₉H₁₀O₂
• 分子量: 150.177
• InChiKey: MYGHRGDHIRSOKL-UHFFFAOYSA-N

物化性质

• 熔点：
  116 °C
• 沸点：
  331.0±42.0 °C(Predicted)
• 密度：
  1.301±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2906299090

反应信息

• 作为反应物：
  描述：

  2,3-dihydro-1H-indene-5,6-diol 在 乙醚 、 sodium sulfate 、 silver(l) oxide 作用下， 生成 2,3-dihydro-1H-indene-5,6-dione
  参考文献：
  名称：

  70.酚和酮的缩合产物。第二部分邻苯二酚和丙酮

  摘要：

  DOI：

  10.1039/jr9380000347
• 作为产物：
  描述：

  5,6-二甲氧基茚酮 在 盐酸 、 三溴化硼 、 汞 、 锌 作用下， 以 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 9.0h， 生成 2,3-dihydro-1H-indene-5,6-diol
  参考文献：
  名称：

  Synthesis and antianxiety activity of (.omega.-piperazinylalkoxy)indan derivatives

  摘要：

  A series of (omega-piperazinylalkoxy)indan derivatives has been synthesized and screened for potential antianxiety activities. The effect of structural modification of these molecules on activities has been systemically examined. Antianxiety activity was displayed by 5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (2), 5-[3-[4-(4-fluorophenyl)-1-piperazinyl]-propoxy]indan (8), 6-fluoro-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (33), and 6-methyl-5-[3-(4-phenyl-1-piperazinyl)propoxy]indan (42), as determined in antifighting and anti-morphine tests. These derivatives in antianxiety tests were equipotent or more potent than chlordiazepoxide with less muscle-relaxant effect. They also showed weak neuroleptic-like action.

  DOI：

  10.1021/jm00356a024

文献信息

• A New Entry to the Synthesis of 1,2-Benzenediol Congeners.
  作者：Yutaka OZAKI、Ikumi OSHIO、Yasue OHSUGA、Shouichi KABURAGI、Zhung-Zhu SUNG、Sang-Won KIM

  DOI：10.1248/cpb.39.1132

  日期：——

  1, 2-Benzenediols were synthesized via 1, 1-bis(ethylthio)-3-cyclohexen-2-one derivatives, which were prepared by condensation of 1, 1-bis(ethylthio)-2-propanone with Mannich bases. Regioselective preparation of their monoethers was also achieved.

  1, 2-苯二醇通过1, 1-双(乙硫基)-3-环己烯-2-酮衍生物合成，这些衍生物是通过1, 1-双(乙硫基)-2-丙酮与曼尼希碱的缩合反应制备的。同时，单醚的位选择性合成也得以实现。
• Palladium-Catalyzed Asymmetric Dihydroxylation of 1,3-Dienes with Catechols
  作者：Tao Fan、Hong-Cheng Shen、Zhi-Yong Han、Liu-Zhu Gong

  DOI：10.1002/cjoc.201800540

  日期：2019.3

  palladium‐catalyzed asymmetric dihydroxylation of 1,3‐dienes with catechols is developed using chiral pyridinebis(oxazoline) ligands. Various chiral 2‐substituted 1,4‐benzodioxanes could be synthesized with moderate to high yields and enantioselectivities from readily available starting materials. The reaction is proposed to proceed through a cascade Wacker‐type hydroxypalladation/asymmetric allylation process

  使用手性吡啶双（恶唑啉）配体开发了钯催化的1,3-二烯与邻苯二酚的不对称二羟基化反应。各种手性的2-取代的1,4-苯并二恶烷可以容易获得的起始原料合成，具有中等至高收率和对映选择性。建议该反应通过级联的Wacker型羟基palladation /不对称烯丙基化过程进行。
• Ru₃(CO)₁₂-Catalyzed Reaction of 1,6-Diynes, Carbon Monoxide, and Water via the Reductive Coupling of Carbon Monoxide
  作者：Cathleen M. Crudden、Yuuki Maekawa、Joshua J. Clarke、Tomohide Ida、Yoshiya Fukumoto、Naoto Chatani、Shinji Murai

  DOI：10.1021/acs.orglett.0c02349

  日期：2020.11.20

  We report the ruthenium-catalyzed cyclization of 1,6-diynes with two molecules of carbon monoxide and water to give a variety of catechols. This reaction likely proceeds through the intermediacy of the water–gas shift reaction to generate an yne–diol-type intermediate followed by a [4 + 2] cycloaddition with 1,6-diynes. The reaction requires no external reductants or hydride sources and provides a

  我们报道了钌催化的1，6-二炔与两分子一氧化碳和水的环化反应，得到了多种儿茶酚。该反应可能通过水煤气变换反应的中间过程进行，生成炔二醇类型的中间体，然后与1，6-二炔进行[4 + 2]环加成反应。该反应不需要外部还原剂或氢化物源，并提供了一种新颖且有价值的合成多种儿茶酚的方法。
• Structure–Activity Relationship in the Domain of Odorants Having Marine Notes
  作者：Jean-Marc Gaudin、Olga Nikolaenko、Jean-Yves de Saint Laumer、Beat Winter、Pierre-Alain Blanc

  DOI：10.1002/hlca.200790126

  日期：2007.7

  9-tetrahydro-7H-benzocyclohepten-7-ones 11 (Schemes 5 and 6), since the lead compound for the olfactory note of perfumes based on marine accords is a well-known benzodioxepinone named Calone 1951® (9b). We meticulously described the odor profile of each synthesized compound and discussed relevant structure–odor relationships (Tables 1–3). In particular, we revealed a correlation between the conformation of the seven-membered

  我们合成或重新合成了大量2 H -1,5-benzodioxepin-3（4 H）-ones 9（方案1），4,5-dihydro-1-benzoxepin-3（2 H）-ones 10（方案3和4）和5,6,8,9-四氢-7 H-苯并环庚烯-7-酮11（方案5和6），因为基于海洋协议的香水嗅觉的先导化合物很好命名-known benzodioxepinone使Calone 1951年®（9B）。我们精心描述的每个合成的化合物的气味特征和讨论有关结构气味的关系（表1 - 3）。特别地，我们揭示了七元环的构象与这些化合物的活性之间的相关性（表4和图3）。我们还阐明了芳环上烷基取代基的位置和大小的影响。
• Systems and Methods for the Depolymerization of a Biopolymer
  申请人：YALE UNIVERSITY

  公开号：US20160130202A1

  公开（公告）日：2016-05-12

  Methods for the production and isolation of a monomer from a biopolymer are described. The method includes extracting a biopolymer from a biopolymer source and depolymerizing the biopolymer into a monomer. Methods for the production and isolation of a monomer from corn lignin are also described. The method includes extracting corn lignin from corn biomass and depolymerizing the corn lignin into a monomer.

  描述了从生物聚合物中生产和分离单体的方法。该方法包括从生物聚合物源中提取生物聚合物，并将生物聚合物降解为单体。还描述了从玉米木质素中生产和分离单体的方法。该方法包括从玉米生物质中提取玉米木质素，并将玉米木质素降解为单体。