(2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(2,3-bis(stearoyloxy)propoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate | 1357286-90-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(2,3-bis(stearoyloxy)propoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
• CAS: 1357286-90-8
• 化学式: C₅₃H₉₄O₁₄
• 分子量: 955.321
• InChiKey: KTKVRIJIGJZXDJ-ZCLMFKIHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.06
• 重原子数：
  67.0
• 可旋转键数：
  43.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  176.26
• 氢给体数：
  0.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(2,3-bis(stearoyloxy)propoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 在 水 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以86%的产率得到单半乳糖甘油二酯
  参考文献：
  名称：

  An efficient and versatile chemical synthesis of bioactive glyco-glycerolipids

  摘要：

  Synthesis of beta-glyco-1,2-diacylglycerols is achieved by a versatile and simple procedure based on trichloro-acetimidate methodology and use of peracetate sugar substrates. The chemical strategy was tested through stereoselective preparation of beta-galacto- and beta-gluco-lipid derivatives capable to trigger immune system response. The synthetic approach is designed to obtain enantiomerically pure regio- and stereo-isomers including derivatives containing poly-unsaturated fatty acids. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.030
• 作为产物：
  描述：

  2,3,4,6-O-四乙酰基-D-半乳糖 在 4-二甲氨基吡啶 、 zinc(II) nitrate hexahydrate 、 三氟化硼乙醚 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 8.0h， 生成 (2R,3S,4S,5R,6R)-2-(acetoxymethyl)-6-(2,3-bis(stearoyloxy)propoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
  参考文献：
  名称：

  An efficient and versatile chemical synthesis of bioactive glyco-glycerolipids

  摘要：

  Synthesis of beta-glyco-1,2-diacylglycerols is achieved by a versatile and simple procedure based on trichloro-acetimidate methodology and use of peracetate sugar substrates. The chemical strategy was tested through stereoselective preparation of beta-galacto- and beta-gluco-lipid derivatives capable to trigger immune system response. The synthetic approach is designed to obtain enantiomerically pure regio- and stereo-isomers including derivatives containing poly-unsaturated fatty acids. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.030