4-(3-Chlor-anilino)-2-oxo-2,5-dihydro-furan | 22273-69-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-Chlor-anilino)-2-oxo-2,5-dihydro-furan
• 英文别名: 4-(3-chloro-anilino)-5H-furan-2-one；3-(3-chloroanilino)-2H-furan-5-one
• CAS: 22273-69-4
• 化学式: C₁₀H₈ClNO₂
• 分子量: 209.632
• InChiKey: XCEBXIPTSPAXAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-Chlor-anilino)-2-oxo-2,5-dihydro-furan 、 6-硝基靛红 、 丙二腈 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以79%的产率得到2-amino-1-(3-chlorophenyl)-5'-nitro-2',5-dioxo-5,7-dihydro-1H-spiro[furo[3,4-b]pyridine-4,3'-indoline]-3-carbonitrile
  参考文献：
  名称：

  A facile one-pot ultrasound assisted for an efficient synthesis of 1H-spiro[furo[3,4-b]pyridine-4,3′-indoline]-3-carbonitriles

  摘要：

  A convenient one-pot protocol was developed for the synthesis of 1H-spiro[furo[3,4-6]pyridine-4,3 '-indoline1-3-carbonitrile derivatives. This reaction was carried out through a three component condensation reaction of isatins, malononitrile, and anilinolactones in the presence of a catalytic amount of Et3N as an inexpensive and available basic catalyst in THF under ultrasound irradiation. The products were obtained in high yields and short reaction times. The main advantage of this synthetic method is that the obtained products in ultrasonic irradiations are different from classical heating. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2014.02.014

文献信息

• Supported molybdenum on graphene oxide/Fe3O4: An efficient, magnetically separable catalyst for one-pot construction of spiro-oxindole dihydropyridines in deep eutectic solvent under microwave irradiation
  作者：Mo Zhang、Yu-Heng Liu、Ze-Ren Shang、Hai-Chuan Hu、Zhan-Hui Zhang

  DOI：10.1016/j.catcom.2016.09.028

  日期：2017.1

  Magnetically separable graphene oxide supported molybdenum (Fe3O4/GO-Mo) nanoparticles were prepared and characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and vibrating sample magnetometry (VSM) techniques. The synthesized heterogeneous material was found to exhibit high catalytic activity

  磁性可分离的氧化石墨烯负载的钼（Fe 3 O 4/ GO-Mo）纳米粒子的制备和表征，包括X射线衍射（XRD），扫描电子显微镜（SEM），透射电子显微镜（TEM），傅里叶变换红外光谱（FT-IR）和振动样品磁强度（VSM）技术。发现合成异质材料在微波辐射下，用氯化胆碱（ChCl）/脲作为绿色溶剂，在靛红，丙二腈和苯胺内酯的一锅，三组分反应中显示出高催化活性。它提供了一种高效，高产率地合成螺并吲哚二氢吡啶的有效方法。催化系统可以成功地重复使用八次，而催化性能的下降很小。
• Manganese ferrite nanoparticle catalyzed tandem and green synthesis of spirooxindoles
  作者：Ramin Ghahremanzadeh、Zahra Rashid、Amir-Hassan Zarnani、Hossein Naeimi

  DOI：10.1039/c4ra05756b

  日期：——

  PEG-400 as a nontoxic, green and reusable solvent was used for the synthesis of novel spiro-furo-pyridine-indoline-carbonitriles in the presence of a magnetically recoverable nanocatalyst.

  使用PEG-400作为无毒、绿色和可重复使用的溶剂，在具有可磁性回收的纳米催化剂存在下合成了新型螺环呋喃吡啶-吲哚-腈化合物。