依芬普司-去乙基 | 80854-21-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 依芬普司-去乙基
• 中文别名: 醚菊酯-脱乙基,10ΜG/ΜL于环己烷；叔-丁基4-[3-氨基-5-(三氟甲基)苯甲基]哌嗪-1-羧酸酯
• 英文名称: 3-phenoxybenzyl 2-(4-hydroxyphenyl)-2-methylpropyl ether
• 英文别名: 2-(4-hydroxyphenyl)-2-methylpropyl 3-phenoxybenzyl ether；2-(4-hydroxyphenyl)-2-methylpropyl phenoxybenzyl ether；Phenol, 4-(1,1-dimethyl-2-((3-phenoxyphenyl)methoxy)ethyl)-；4-[2-methyl-1-[(3-phenoxyphenyl)methoxy]propan-2-yl]phenol
• CAS: 80854-21-3
• 化学式: C₂₃H₂₄O₃
• 分子量: 348.442
• InChiKey: VCQNNXOZNOPALT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  碘乙烷 、 依芬普司-去乙基 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 14.0h， 以86%的产率得到醚菊酯
  参考文献：
  名称：

  在环丙烷环上具有两个不对称中心的新型拟除虫菊酯的合成和立体结构-活性关系

  摘要：

  合成了带有手性氰醇酯或手性醚和环丙烷环上的两个不对称中心的2-甲基环丙烷拟除虫菊酯杀虫剂。这些化合物是分别使用氰戊菊酯中的异丙基和 Etofenprox 类似物（甲基、乙基形式）中的两个二甲基之间的“反向连接方法”设计的。这些合成是通过市售的 (±)-、(R)- 和 (S)-环氧丙烷的开环反应实现的，使用 4-氯苄基氰阴离子作为关键步骤，产品的总产率 >98 % ee。对成对的非手性非对映体 (1R*,2S*)-、(1R*,2R*)-氰醇酯和 (1R*,2S*)-、（ 1R*,2R*)-醚类；只有 (1R*, 2R*)-乙醚显着有效。对于对映体 (1S,2S)-醚和 (1R,2R)-醚，活性明显集中在 (1R,2R)-醚上。目前的立体结构-活性关系表明 (i) 氰戊菊酯衍生的氰醇酯出乎意料地无活性，而依托芬普罗衍生的醚具有活性，以及​​ (ii) (1S,2S)-醚和 (1R,2R) 之间

  DOI：

  10.3390/molecules24061023
• 作为产物：
  描述：

  苯乙醚 在 氢氧化钾 、 硫酸 作用下， 以 二甲基亚砜 为溶剂， 反应 20.0h， 生成 依芬普司-去乙基
  参考文献：
  名称：

  摘要：

  An ethophenprox synthesis from, easily available p-nitroneophyl chloride was developed. The reduction of the latter to aniline derivative followed by Sandmayer's and Claisen's reactions furnished p-ethoxyneophyl chloride that by condensation with 3-phenoxybenzyl alcohol in the presence KOH in DMSO yielded ethophenprox.

  DOI：

  10.1023/a:1022562101602

文献信息

• Insecticidal resin coating film
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US04818525A1

  公开（公告）日：1989-04-04

  An insecticidal resin coating film comprising a combination of an acrylonitrile and/or methacrylonitrile copolymer resin and an insecticidal component selected from the group consisting of specified compounds exhibits an insecticidal effect, since the compound is kept on the surface of the coating film in a state capable of exhibiting its insecticidal effect for a long period of time.

  一种含有丙烯腈和/或甲基丙烯腈共聚物树脂和从指定化合物组成的昆虫杀虫成分中选择的组合的杀虫树脂涂膜，由于该化合物被保持在涂膜表面上，能够长时间展现其杀虫效果。
• Preparation of a difluorohalomethoxybenzene
  申请人：Mitsui Toatsu Chemicals, Incorporated

  公开号：US05105021A1

  公开（公告）日：1992-04-14

  A higher yield of the difluorohalomethoxybenzene produced by the reaction of a metal phenolate with dibromodifluoromethane or bromochlorodifluoromethane can be obtained by conducting the addition of a metal alcoholate or a metal hydride as a reaction initiator to a solution or a suspension of an aprotic polar solvent containing the metal phenolate and dibromodifluoromethane or bromochlorodifluoromethane.

  通过在含有金属酚酸盐和二溴二氟甲烷或溴氯二氟甲烷的无极性极性溶剂的溶液或悬浮液中加入金属醇盐或金属氢化物作为反应引发剂，可以获得通过金属酚酸盐与二溴二氟甲烷或溴氯二氟甲烷反应产生的二氟卤甲氧基苯的更高产量。
• 2-Arylpropyl ether or thioether derivatives and insecticidal and
  申请人：Mitsuitoatsu Chemicals Inc.

  公开号：US04397864A1

  公开（公告）日：1983-08-09

  The present invention relates to 2-arylpropyl ether or thioether derivatives represented by the following general formula [I]: ##STR1## wherein Ar stands for an aryl group, R stands for a methyl or ethyl group, Y stands for an oxygen or sulfur atom, and B stands for a group represented by the following formula [II]: ##STR2## or the following general formula [III]: ##STR3## wherein Z stands for an oxygen or sulfur atom or a carbonyl or methylene group, R.sup.1 stands for a hydrogen or halogen atom or a lower alkyl group or a lower alkoxy group, and n is an integer of from 1 to 5 with the proviso that when n is 2 or more, the groups R.sup.1 may be the same or different, and also to processes for the preparation or these ethers of thioethers and a use of these ethers or thioethers. These compounds of the present invention have excellent insecticidal and acaricidal activities while the toxicity of these compounds are very low.

  本发明涉及由以下一般式[I]表示的2-芳基丙基醚或硫醚衍生物：其中Ar代表芳基，R代表甲基或乙基，Y代表氧原子或硫原子，B代表由以下式[I]或以下一般式[III]表示的基团：其中Z代表氧原子或硫原子或羰基或亚甲基基团，R1代表氢原子或卤素原子或较低烷基基团或较低烷氧基团，n是1至5的整数，但当n为2或更多时，基团R1可以相同或不同，并且本发明还涉及制备这些醚或硫醚的方法以及这些醚或硫醚的用途。这些本发明的化合物具有出色的杀虫和杀螨活性，同时这些化合物的毒性非常低。
• Difluorobromomethoxyphenyl derivative and miticide comprising said
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US04782094A1

  公开（公告）日：1988-11-01

  A difluorobromomethyoxyphenyl derivative of the general formula ##STR1## wherein A represents an oxygen atom or a methylene group, and Y represents a hydrogen or fluorine atom. A miticide comprising the above derivative as an active ingredient is also provided.

  本发明提供了一种通式##STR1##中，A代表氧原子或亚甲基基团，Y代表氢原子或氟原子的二氟溴甲氧基苯衍生物。还提供了一种以上述衍生物为活性成分的杀螨剂。
• Immunological detection method of pyrethroid compound, haptenic
  申请人：Mitsui Toatsu Chemicals, Inc.

  公开号：US05608104A1

  公开（公告）日：1997-03-04

  Described is a detection method of a pyrethroid compound which comprises providing a first antibody against the pyrethroid compound, said first antibody having been obtained by immunizing a responder with an immunogen which is a first conjugate between a first carrier and a first haptenic compound represented by the following formula (1) or (2): ##STR1## mixing the first antibody with the sample solution, causing any unreacted portion of the first antibody to be bound on a second conjugate as a coated antigen, said second conjugate being formed of a second carrier and a second haptenic compound and having been coated on a surface of a solid phase carrier, whereby an antigen-antibody conjugate is obtained; and reacting the antigen-antibody conjugate with a second antibody against the first antibody, said second antibody having a labelled enzyme linked therewith. This invention has made it possible to conduct easy, economical and quick analysis of a pyrethroid compound contained in our surroundings such as water or soil, plants or foods.

  本发明涉及一种拟除虫菊酯化合物的检测方法，包括提供第一抗体来检测拟除虫菊酯化合物。所述第一抗体是通过将响应体免疫于免疫原（一种第一载体和第一半抗原化合物之间的第一缀合物，该化合物由以下公式（1）或（2）表示）而获得的。将第一抗体与样品溶液混合，使第一抗体的任何未反应部分结合在第二缀合物上，作为涂层抗原，所述第二缀合物由第二载体和第二半抗原化合物形成，并被涂覆在固相载体的表面上，从而获得抗原-抗体缀合物。然后，将抗原-抗体缀合物与第二抗体反应，所述第二抗体与标记酶链接。本发明使得在我们周围的水或土壤、植物或食品中含有的拟除虫菊酯化合物的易于、经济、快速分析成为可能。