High throughput screening enabled the development of a Cu-based catalyst system for the asymmetric hydrogenation of prochiral aryl and heteroaryl ketones that operates at H2 pressures as low as 5 bar. A ligand combination of (R,S)-N-Me-3,5-xylyl-BoPhoz and tris(3,5-xylyl)phosphine provided benzylic alcohols in good yields and enantioselectivities. The electronic and steric characteristics of the ancillary
高通量筛选使得能够开发用于在低至5 bar的H 2压力下进行的前手性芳基和杂芳基酮的不对称氢化的Cu基催化剂体系。(R,S)-N -Me-3,5-二
甲苯基-BoPhoz和三(3,5-二
甲苯基)膦的
配体组合以良好的收率和对映选择性提供了
苄醇。辅助三芳基膦的电子和空间特性对于确定反应性和选择性均很重要。