2-磺基十八烷酸 | 1115-17-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-磺基十八烷酸
• 中文别名: 2-磺酸基硬脂酸
• 英文名称: 2-sulfo-octadecanoic acid
• 英文别名: Stearinsaeure-sulfonsaeure-(2)；2-Sulfo-octadecansaeure；2-Sulfo-stearinsaeure；α-sulfo stearic acid；α-sulfostearic acid；α-Sulfostearinsaeure；Octadecanoic acid, 2-sulfo-；2-sulfooctadecanoic acid
• CAS: 1115-17-9
• 化学式: C₁₈H₃₆O₅S
• 分子量: 364.547
• InChiKey: XQITUXIEASXIMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  24
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  癸醇 、 2-磺基十八烷酸 生成 1-decyloxycarbonyl-heptadecane-1-sulfonic acid
  参考文献：
  名称：

  Sodium Salts of Alkyl α-Sulfopalmitates and Stearates^1,2

  摘要：

  DOI：

  10.1021/ja01115a528
• 作为产物：
  描述：

  sodium stearate 在 二氧化硫 作用下， 生成 2-磺基十八烷酸
  参考文献：
  名称：

  Preparation of ammonium and amine salts of acidic organic compounds

  摘要：

  公开号：

  US02324199A1

文献信息

• α‐sulfonated fatty acid esters: II. Solution behavior of α‐sulfonated fatty acid polyethylene glycol esters
  作者：Tomomichi Okano、Naoyuki Egawa、Masami Fujiwara、Masahiro Fukuda

  DOI：10.1007/bf02523445

  日期：1996.1

  Sodium α‐sulfonated, fatty acid polyethylene glycol monoesters [C_mH_2m+1CH(SO₃Na)COO(C₂H₄O)_nH] and diesters [C_mH_2m+1CH(SO₃Na)COO(C₂H₄O)_nCOCH(SO₃Na)C_mH_2m+1], wherem=10–16 andn=1–35, were prepared by esterification of α‐sulfonated, fatty acids with polyethylene glycols, followed by neutralization with NaOH. Crude products were purified by reversed‐phase column chromatography on an octadecyl‐modified silica gel. Characteristic solution behavior of these α‐sulfonated fatty acid esters was, examined, and the following features were observed. All monoesters prepared in this work had Krafft points below 0°C and also possessed good calcium stabilities. Critical micelle concentrations of the monoesters increased monotonously, as a rule, with an increase in the number of oxyethylene units. These results suggest that the polyethylene glycol residue of the monoester behaves as a hydrophile. On the other hand, diesters possessed high water solubility, low foamability, and critical micelle concentrations that were lower by a factor of ten compared to those of the monoesters.

  摘要α-磺化脂肪酸聚乙二醇单酯[CmH2m+1CH(SO3Na)COO(C2H4O)nH]和二酯[CmH2m+1CH(SO3Na)COO(C2H4O)nCOCH(SO3Na)CmH2m+1]、其中，m=10-16，n=1-35，是由α-磺化脂肪酸与聚乙二醇酯化，然后用 NaOH 中和制备的。粗产物在十八烷基改性硅胶上通过反相柱色谱法纯化。对这些 α-磺化脂肪酸酯的溶液特性进行了研究，发现它们具有以下特点。本研究制备的所有单酯的克拉夫特点均低于 0°C，并具有良好的钙稳定性。单酯的临界胶束浓度通常随着氧乙烯单元数量的增加而单调增加。这些结果表明，单酯的聚乙二醇残基具有亲水性。另一方面，二酯具有高水溶性、低发泡性，临界胶束浓度比单酯低十倍。
• Improvements in or relating to polymeric compounds
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0358400A2

  公开（公告）日：1990-03-14

  A polymeric compound is derived from a polyhydric material and has pendant sulphonate groups of the general formula where X is an aliphatic, aromatic, carbocylic or heterocyclic group; Y is hydrogen, halogen or an alkyl, aryl, alkoxy, aryloxy or aralkyl group, CO₂⁻Z⁺, CO₂R or SO₃⁻Z⁺; Z⁺ is a cationic counter ion and R is hydrogen, alkyl, alkylene, aryl or aralkyl group.

  一种聚合化合物来源于多水材料，并具有通式如下的悬垂磺酸基团 其中，X 是脂肪族、芳香族、羰基或杂环基；Y 是氢、卤素或烷基、芳基、烷氧基、芳氧基或芳烷基、CO₂-Z⁺、CO₂R 或 SO₃-Z⁺；Z⁺ 是阳离子反离子，R 是氢、烷基、亚烷基、芳基或芳烷基。
• New lysosphingolipid derivatives
  申请人：FIDIA S.p.A.

  公开号：EP0373038A2

  公开（公告）日：1990-06-13

  Novel derivatives of lysophingolipids free from sialic acids which are N-acyllysosphingolipids having one of the two formulae: in which -A- stands for the group -CH=CH- or -CH₂-CH₂-, n₁ is a whole number of between 6 and 18, n₂ a whole number of between 11 and 15, X is a hydrogen atom or the residue of a monosaccharide or a disaccharide or phosphorylcholine and R represents an alkyl radical derived from a saturated or unsaturated aliphatic carboxylic acid having from 2 to 24 carbon atoms substituted by one or more polar groups. The lysosphingolipid derivatives of the invention exhibit an inhibiting action on protein-kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system.

  不含硅酸的溶血鞘磷脂新衍生物，属于具有以下两种式子之一的 N-酰基鞘磷脂： 其中 -A- 代表基团 -CH=CH- 或 -CH₂-CH₂-，n₁ 是介于 6 和 18 之间的整数，n₂ 是介于 11 和 15 之间的整数、X 是氢原子或单糖、双糖或磷酸胆碱的残基，R 代表烷基，衍生自具有 2 至 24 个碳原子的饱和或不饱和脂肪族羧酸，并被一个或多个极性基团取代。本发明的溶血磷脂衍生物对蛋白激酶 C 的活化具有抑制作用，因此可用于治疗神经系统的各种病症。
• Di-lysogangliosides derivatives
  申请人：FIDIA S.p.A.

  公开号：EP0410883A2

  公开（公告）日：1991-01-30

  N-acyl-N,N′-di-lysogangliosides, N′-acyl-N,N′-di-­lysogangliosides and N,N′-diacyl-N,N′-di-­lysogangliosides, wherein the acyl groups are derived from an aliphatic acid having from 1 to 24 carbon atoms, substituted by one or more polar groups. The acyl-di-­lysogangliosides of the invention exhibit an inhibiting action on protein kinase C activation and, thus, can be utilized in therapies for various pathologies of the nervous system. Pharmaceutical compositions and therapeutic utilities for the lysoganglioside derivatives are also disclosed.

  N-acyl-N,N′-di-lysogangliosides, N′-acyl-N,N′-di-lysogangliosides和N,N′-diacyl-N,N′-di-lysogangliosides，其中酰基来自具有1至24个碳原子的脂肪族酸，并被一个或多个极性基团取代。本发明的酰基二-赖索神经节苷脂对蛋白激酶 C 的活化具有抑制作用，因此可用于治疗神经系统的各种病症。本发明还公开了溶糖神经节苷脂衍生物的药物组合物和治疗用途。
• Polymeric compounds
  申请人：Du Pont (UK) Limited

  公开号：EP0442638A2

  公开（公告）日：1991-08-21

  A polymeric compound is derived from a polyhydric material and has pendant sulphonate groups of the general formula and pendant alkyl urethane groups of the formula where X is an aliphatic, aromatic, carboxylic or heterocyclic group; Y is hydrogen, halogen or an alkyl, aryl, alkoxy, aryloxy or aralkyl group, CO₂⁻Z⁺, CO₂R or SO₃⁻Z⁺; Z⁺ is a cationic counter ion and R is hydrogen alkyl, alkylene, aryl or aralkyl group.

  一种聚合化合物来源于一种多水材料，并具有通式如下的悬垂磺酸基团 和式中的烷基聚氨酯基团 其中，X 是脂肪族、芳香族、羧基或杂环基；Y 是氢、卤素或烷基、芳基、烷氧基、芳氧基或芳烷基、CO₂-Z⁺、CO₂R 或 SO₃-Z⁺；Z⁺ 是阳离子反离子，R 是氢烷基、亚烷基、芳基或芳烷基。