6-deutero-5-methyl-1-phenylpyridin-2(H)-one | 1132025-33-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-deutero-5-methyl-1-phenylpyridin-2(H)-one
• 英文别名: 6-Deuterio-5-methyl-1-phenylpyridin-2-one
• CAS: 1132025-33-2
• 化学式: C₁₂H₁₁NO
• 分子量: 186.218
• InChiKey: ISWRGOKTTBVCFA-QOWOAITPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  哌非尼酮 在 氘氧化钠 、 氘代盐酸 作用下， 以 氘代甲醇 、 重水 为溶剂， 反应 16.0h， 生成 6-deutero-5-methyl-1-phenylpyridin-2(H)-one
  参考文献：
  名称：

  [EN] DEUTERATED PIRFENIDONE
  [FR] PIRFÉNIDONE DÉUTÉRÉE

  摘要：

  本发明涉及新颖的取代吡啶酮、其衍生物、药学上可接受的盐、溶剂化合物和水合物。本发明还提供了包含本发明化合物的组合物，并且利用这些组合物治疗通过给予TNF（肿瘤坏死因子）-α产生抑制剂/TGF（转化生长因子）-β抑制剂有益治疗的疾病和病症的方法。

  公开号：

  WO2009035598A1

文献信息

• Deuterated pirfenidone
  申请人：Liu Julie F.

  公开号：US20090131485A1

  公开（公告）日：2009-05-21

  This invention relates to novel substituted pyridinones, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a TNF (tumor necrosis factor)-alpha production inhibitor/TGF (transforming growth factor)-beta inhibitor.
• DEUTERATED PIRFENIDONE
  申请人：Liu Julie F.

  公开号：US20130018193A1

  公开（公告）日：2013-01-17

  This invention relates to novel substituted pyridinones, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a TNF (tumor necrosis factor)-alpha production inhibitor/TGF (transforming growth factor)-beta inhibitor.
• [EN] DEUTERATED PIRFENIDONE<br/>[FR] PIRFÉNIDONE DÉUTÉRÉE
  申请人：CONCERT PHARMACEUTICALS INC

  公开号：WO2009035598A1

  公开（公告）日：2009-03-19

  This invention relates to novel substituted pyridinones, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a TNF (tumor necrosis factor)-alpha production inhibitor/TGF (transforming growth factor)-beta inhibitor.

  本发明涉及新颖的取代吡啶酮、其衍生物、药学上可接受的盐、溶剂化合物和水合物。本发明还提供了包含本发明化合物的组合物，并且利用这些组合物治疗通过给予TNF（肿瘤坏死因子）-α产生抑制剂/TGF（转化生长因子）-β抑制剂有益治疗的疾病和病症的方法。