isopropylmalate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: isopropylmalate
• 英文别名: 2-Hydroxy-4-oxo-4-propan-2-yloxybutanoic acid
• 化学式: C₇H₁₂O₅
• 分子量: 176.169
• InChiKey: GYDOWLCNBQVRKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  苹果酸 、 异丙醇 在 硼酸 作用下， 反应 18.0h， 生成 3-Hydroxy-4-oxo-4-propan-2-yloxybutanoic acid 、 isopropylmalate
  参考文献：
  名称：

  硼酸催化α-羟基羧酸的化学选择性酯化。

  摘要：

  硼酸催化α-羟基羧酸的选择性酯化反应，而不会引起与其他羧酸的明显酯化反应。该过程简单，高产率，并且适用于在同一分子内存在其他羧酸（包括β-羟基酸）的情况下对α-羟基羧酸酯进行酯化。[反应：看文字]

  DOI：

  10.1021/ol036123g

文献信息

• METHOD FOR PRODUCING 3-AMINOMETHYLTETRAHYDROFURAN DERIVATIVE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1780205A1

  公开（公告）日：2007-05-02

  An object of the present invention is to provide a process for producing a 3-cyanotetrahydrofuran derivative in a high yield from inexpensive industrial materials. According to the present invention, a 3-aminomethyltetrahydrofuran derivative is produced by preparing a 3-cyanotetrahydrofuran derivative in a high yield from an inexpensive and industrially easily available malic acid derivative, and reducing the cyano group of the 3-cyanotetrahydrofuran derivative.

  本发明的一个目的是提供一种从廉价的工业原料中高产率生产3-氰基四氢呋喃衍生物的方法。根据本发明，通过从廉价且工业上易获得的苹果酸衍生物制备高产率的3-氰基四氢呋喃衍生物，然后还原3-氰基四氢呋喃衍生物的氰基，从而制备3-氨甲基四氢呋喃衍生物。
• PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE ELEMENT, METHOD FOR FORMING RESIST PATTERN, AND METHOD FOR PRODUCING PRINTED WIRING BOARD
  申请人：Hitachi Chemical Company, Ltd.

  公开号：EP2063318A1

  公开（公告）日：2009-05-27

  A photosensitive resin composition comprising (A) a binder polymer, (B) a photopolymerizing compound with an ethylenic unsaturated bond, and (C) a photopolymerization initiator, wherein component (B) includes a photopolymerizing compound with an organic group represented by the following general formula (1). In the formula, R1 and R2 each independently represent hydrogen or a methyl group, L1 and L2 each independently represent a C1-6 alkylene group and m and n each independently represent an integer of 0-50 selected so that the total of m and n is 0-50.

  一种光敏树脂组合物，包括(A)粘合剂聚合物，(B)具有乙烯基不饱和键的光聚合化合物，和(C)光聚合引发剂，其中组分(B)包括具有下通式(1)所代表的有机基团的光聚合化合物。 式中，R1 和 R2 各自独立地代表氢或甲基，L1 和 L2 各自独立地代表 C1-6 亚烷基，m 和 n 各自独立地代表 0-50 的整数，m 和 n 的总和为 0-50。
• ACRYLIC RUBBER COMPOSITION AND VULCANIZATES THEREOF
  申请人：Denki Kagaku Kogyo Kabushiki Kaisha

  公开号：EP2159263A1

  公开（公告）日：2010-03-03

  To provide an acrylic rubber composition and its vulcanized product, having excellent workability and an excellent balance of the vulcanization properties, the reduction of scorching, the rubber mechanical properties, the compression set and the heat resistance. An acrylic rubber composition comprising a carboxy group-containing acrylic rubber, a novolac phenol resin salt of a diazabicycloalkene compound and a polyamine compound. Particularly, the diazabicycloalkene compound is preferably 2,3,4,6,7,8,9,10-octahydropyrimido(1,2-a)azepine or 2,3,4,6,7,8-hexahydropyrrolo(1,2-a)pyrimidine, and the polyamine compound is preferably an aromatic polyamine or an aliphatic polyamine.

  提供一种丙烯酸橡胶组合物及其硫化产品，该组合物具有极佳的加工性，并在硫化性能、减少焦烧、橡胶机械性能、压缩永久变形和耐热性方面实现了极佳的平衡。 一种丙烯酸橡胶组合物，由含羧基的丙烯酸橡胶、重氮双环烯化合物的酚醛树脂盐和多胺化合物组成。特别是，重氮双环烯化合物最好是 2,3,4,6,7,8,9,10-八氢嘧啶并(1,2-a)氮杂卓或 2,3,4,6,7,8-六氢吡咯并(1,2-a)嘧啶，多胺化合物最好是芳香族多胺或脂肪族多胺。
• ACRYLIC RUBBER COMPOSITION, VULCANIZED RUBBER THEREFROM AND USE THEREOF
  申请人：Denki Kagaku Kogyo Kabushiki Kaisha

  公开号：EP2159264A1

  公开（公告）日：2010-03-03

  To provide an acrylic rubber composition and a vulcanized rubber that ensure heat resistance of the vulcanized rubber, especially less changes in the elongation at break (EB) and hardness of the vulcanized rubber under heating conditions. An acrylic rubber composition comprising a carboxyl group-containing acrylic rubber and, per 100 parts by mass of the carboxyl group-containing acrylic rubber, from 10 to 100 parts by mass of carbon black, from 0.1 to 15 parts by mass of at least one primary antioxidant selected from the group consisting of an amine antioxidant and a phenolic antioxidant and from 0.1 to 15 parts by mass of at least one secondary antioxidant selected from the group consisting of a phosphorus antioxidant and a sulfur antioxidant.

  提供一种丙烯酸橡胶组合物和硫化橡胶，确保硫化橡胶的耐热性，特别是在加热条件下硫化橡胶的断裂伸长率（EB）和硬度变化较小。 一种丙烯酸橡胶组合物，包括含羧基的丙烯酸橡胶，以及每 100 份含羧基丙烯酸橡胶中含 10 至 100 份碳黑、0.1 至 15 份至少一种一级抗氧化剂（选自胺类抗氧化剂和酚类抗氧化剂）和 0.1 至 15 份至少一种二级抗氧化剂（选自磷类抗氧化剂和硫类抗氧化剂）。
• PHOTOSENSITIVE RESIN COMPOSITION, PHOTOSENSITIVE ELEMENT, RESIST PATTERN MANUFACTURING METHOD, AND PRINTED CIRCUIT BOARD MANUFACTURING METHOD
  申请人：Hitachi Chemical Company, Ltd.

  公开号：EP2284611A1

  公开（公告）日：2011-02-16

  A photosensitive resin composition comprising a (A) binder polymer, a (B) photopolymerizing compound having ethylenic unsaturated bonds in the molecule, a (C) photopolymerization initiator and a (D) polymerization inhibitor, wherein the (C) photopolymerization initiator comprises an acridine compound, and the content of the (D) polymerization inhibitor is 20-100 ppm by weight.

  一种光敏树脂组合物，包括（A）粘合剂聚合物、（B）分子中含有乙烯不饱和键的光聚合化合物、（C）光聚合引发剂和（D）聚合抑制剂，其中（C）光聚合引发剂包括吖啶化合物，而（D）聚合抑制剂的含量按重量计为 20-100 ppm。