methyl 6-(dichloromethylene)heptanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 6-(dichloromethylene)heptanoate
• 英文别名: Methyl 7,7-dichloro-6-methylhept-6-enoate
• 化学式: C₉H₁₄Cl₂O₂
• 分子量: 225.115
• InChiKey: HRUPORUVQSMLFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  四氯化碳 、 6-氧代庚酸甲酯 在 四氯化钛 、 magnesium 作用下， 以 四氢呋喃 、 1,2-二氯乙烷 为溶剂， 反应 1.0h， 以79%的产率得到methyl 6-(dichloromethylene)heptanoate
  参考文献：
  名称：

  Novel Ambiphilic Dichlorocarbenoid Equivalent in Alkene Cyclopropanation and Carbonyl Olefination

  摘要：

  The Ti-Mg-dichloromethylene complexes derived from the oxidative addition of CCl4 to the Mg-TiCl4 bimetallic species serve as a novel class of ambiphilic dichlorocarbenoid equivalents. Not only is Ti-Mg-dichlorocarbenoid highly selective but also it seems highly reactive in both alkene cyclopropanations and carbonyl dichloromethylenations.

  DOI：

  10.1021/jo052610t

文献信息

• Novel Ambiphilic Dichlorocarbenoid Equivalent in Alkene Cyclopropanation and Carbonyl Olefination
  作者：Ching-Ting Chien、Chia-Chung Tsai、Chi-Hui Tsai、Tsai-Yuan Chang、Ping-Kuei Tsai、Ying-Chuan Wang、Tu-Hsin Yan

  DOI：10.1021/jo052610t

  日期：2006.5.1

  The Ti-Mg-dichloromethylene complexes derived from the oxidative addition of CCl4 to the Mg-TiCl4 bimetallic species serve as a novel class of ambiphilic dichlorocarbenoid equivalents. Not only is Ti-Mg-dichlorocarbenoid highly selective but also it seems highly reactive in both alkene cyclopropanations and carbonyl dichloromethylenations.