N,N'-bis(2-hydroxy-5-sulfobenzyl)ethylenediamine-N,N'-diacetic acid | 3625-86-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-bis(2-hydroxy-5-sulfobenzyl)ethylenediamine-N,N'-diacetic acid
• 英文别名: N,N'-di(2-hydroxy-5-sulphobenzyl)ethylenediamine-N,N'-diacetic acid；N.N'-Bis-carboxmethyl-N.N'-bis-<2-hydroxy-5-sulfo-benzyl>-aethylendiamin；N.N'-Bis-carboxmethyl-N.N'-bis-(2-hydroxy-5-sulfo-benzyl)-aethylendiamin；2-[2-[carboxymethyl-[(2-hydroxy-5-sulfophenyl)methyl]amino]ethyl-[(2-hydroxy-5-sulfophenyl)methyl]amino]acetic acid
• CAS: 3625-86-3
• 化学式: C₂₀H₂₄N₂O₁₂S₂
• 分子量: 548.549
• InChiKey: NPFXDGLJVJSQDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  36
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  247
• 氢给体数：
  6
• 氢受体数：
  14

安全信息

• 海关编码：
  2922509090

反应信息

• 作为反应物：
  描述：

  N,N'-bis(2-hydroxy-5-sulfobenzyl)ethylenediamine-N,N'-diacetic acid 在 双氧水 、 氧气 、 铁粉 、 sodium hydroxide 作用下， 以 水 为溶剂， 生成 N,N'-di(2-hydroxy-5-sulphobenzyl)-ethylenediamine-N,N'-diacetic acid iron(III) sodium salt
  参考文献：
  名称：

  A process for the preparation of Fe(III) chelates of N,N'-di(2-hydroxybenzyl)-ethylenediamine-N,N'-diacetic acid and its derivatives

  摘要：

  公开号：

  EP2289869B1

文献信息

• [EN] A PROCESS FOR THE PREPARATION OF FE(III) CHELATES OF N,N'-DI(2-HYDROXYBENZYL)-ETHYLENEDIAMINE-N,N'-DIACETIC ACID AND ITS DERIVATIVES<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE CHÉLATES DE FE(III) DE L'ACIDE N,N'-DI(2-HYDROXYBENZYL)-ÉTHYLÈNEDIAMINE-N,N'-DIACÉTIQUE ET SES DÉRIVÉS
  申请人：PRZED PROD CONSULTINGOWE ADOB SP Z O O SP K

  公开号：WO2011006763A1

  公开（公告）日：2011-01-20

  The invention relates to the process for the preparation of iron(lll) chelates of N, N'- di(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid and its derivatives of the formula (I) wherein both R substituents have the same meaning and represent H, C1 -C4 alkyl, CH2OH, SO3M or COOM, and M is a sodium, potassium or ammonium cation, wherein the aqueous solution of a corresponding chelating agent is contacted with metallic iron by the circulation of said aqueous solution through the bed of pieces of metallic iron in a flow reactor while simultaneously blowing air or oxygen through the aqueous solution of the chelating agent in the flow reactor, optionally in the presence of a hydrogen peroxide solution. Chelates of the formula (I) are useful as the components of plant fertilizers.

  该发明涉及一种制备铁（III）螯合物N，N'-二（2-羟基苯甲基）乙二胺-N，N'-二乙酸及其衍生物的过程，其化学式为（I），其中两个R取代基具有相同的含义，代表H，C1-C4烷基，CH2OH，SO3M或COOM，M为钠，钾或铵阳离子，其中通过将相应的螯合剂的水溶液通过金属铁的块状床在流动反应器中循环，同时通过在流动反应器中通过螯合剂的水溶液吹送空气或氧气，可选地在过氧化氢溶液的存在下，制备出化学式（I）的螯合物，用作植物肥料的组分。
• [EN] NOVEL CXCR4-TARGETING COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS CIBLANT CXCR4
  申请人：PROVINCIAL HEALTH SERVICES AUTHORITY

  公开号：WO2022082312A1

  公开（公告）日：2022-04-28

  The present disclosure relates to peptidic compounds of Formula A, A-II, A-III, B, or C, or salt or solvate thereof, compositions thereof, and methods of use thereof. The compounds of the present disclosure are useful for targeting CXCR4 for purposes such as imaging and/or therapeutics.

  本公开涉及A，A-II，A-III，B或C的肽化合物，或其盐或溶剂，以及其组合物和使用方法。本公开的化合物可用于针对CXCR4进行成像和/或治疗等目的。
• Surface treatment composition and method for treating surface of substrate by using the same
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0858102A2

  公开（公告）日：1998-08-12

  A surface treatment composition containing a complexing agent as a metal deposition preventive in a liquid medium, in which the complexing agent is an ethylenediaminephenol derivative of the following general formula (1) or its salt: wherein X1 and X2 are hydroxyl groups; Y1 to Y8 are respectively independently a hydrogen atom, a hydroxyl group, a halogen atom, a carboxyl group, a phosphonic acid group, a sulfonic acid group, a carbonyl group, a nitro group, a nitroso group, an amino group, an imino group, a nitrilo group, a nitrile group, a thiocyanate group, a hydroxyamino group, a hydroxyimino group, or an alkyl or alkoxy group which may have a substituent, provided that at least one of Y1 to Y8 is not a hydrogen atom; Z1 to Z4 are respectively independently a hydrogen atom, a carboxyl group or a sulfonic acid group; and R1 to R4 are respectively independently a hydrogen atom or an alkyl group which may have a substituent.

  一种含有络合剂的表面处理组合物，作为液体介质中的金属沉积防止剂，其中的络合剂是下式通式(1)的乙二胺苯酚衍生物或其盐： 其中 X1 和 X2 为羟基；Y1至Y8分别独立地为氢原子、羟基、卤素原子、羧基、膦酸基、磺酸基、羰基、硝基、亚硝基、氨基亚氨基、硝基、腈基、硫氰酸基、羟基氨基、羟基亚氨基、或可具有取代基的烷基或 烷氧基，条件是 Y1 至 Y8 中至少有一个不是氢原子；Z1 至 Z4 分别独立地为氢原子、羧基或磺酸基；以及 R1 至 R4 分别独立地为氢原子或可带有取代基的烷基。
• Library of pH responsive polymers and nanoprobes thereof
  申请人：The Board of Regents of the University of Texas System

  公开号：US10098971B2

  公开（公告）日：2018-10-16

  The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

  本公开涉及含有对 pH 值敏感的疏水和亲水段的聚合物。在某些方面，聚合物形成对 pH 值敏感的胶束，并根据特定 pH 值导致荧光变化。在某些方面，本公开还提供了将聚合物用于细胞或细胞外环境成像或递送药物的方法。
• Radiolabeled melanocortin 1 receptor-specific alpha-melanocyte-stimulating hormone analogues for imaging or therapy
  申请人：PROVINCIAL HEALTH SERVICES AUTHORITY

  公开号：US11395857B2

  公开（公告）日：2022-07-26

  A compound is provided comprising a melanocortin 1 receptor (MC1R) targeting peptide (MC1RTP), a radiolabeling group, and a linker joining the MC1RTP to the radio labeling group. The MC1RTP is linear or cyclized, and comprises a sequence of Formula I or Formula II: Xaa1-Xaa2a-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7a (I) or Xaa1-Xaa2b-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7b (II). Xaa1 is L-/D-Nle, L-/D-Nle, L-/D-Ala, L-/D-Leu, L-/D-Ile, D-Ile, L-/D-Cys, L-/D-Met, L-/D-Phe, L-/D-Trp, L-/D-Val, L-/D-Nal, L-/D-2-Nal, Gly, L-/D-α-aminobutryic acid, L-/D-norvaline, or L-/D-homonorleucine. Xaa2a and Xaa7b are L-/D-Cys, L-/D-Asp, L-/D-Glu, L-/D-2-Aad, L-/D-3-Aad, L-/D-Pra, L-/D-Hpg, or L-/D-Bpg. Xaa2b and Xaa7a are L-/D-Cys, L-/D-Lys, L-/D-Orn, L-/D-Dab, L-/D-Dap, L-/D-Lys(N3), L-/D-Orn(N3), L-/D-Dab(N3), L-/D-Dap(N3), L-/D-2-(5′-azidopentyl)alanine, or L-/D-2-(6′-azidohexyl)alanine. Xaa3 is L-/D-His, Pro, beta-(1,2,3-triazol-4-yl)-L-alanine, beta-(1,2,3-triazol-4-yl)-D-alanine, 1,2,4-triazole-3-alanine, or 1,2,4-triazole-3-D-alanine. Xaa4 is L-/D-Phe, L-/D-2-Nal, L-/D-Phe(4-F), L-/D-Phe(4-Cl), L-/D-Phe(4-Br), L-/D-Phe(4-I), L-/D-Phe(4-NH2), or L-/D-Phe(4-NO2). Xaa5 is L-/D-Arg, L-/D-hArg), Leu, L-/D-Agb, or L-/D-Agp. Xaa6 is L-/D-Trp, L-/D-Phe, L-/D-Trp(5-Br), L-/D-Trp(5-OCH3), L-/D-Trp(6-F), L-/D-Trp(5-OH) or L-/D-Trp(CHO). One or more amino acid residues of the MC1RTP is alpha N-methylated, wherein 1, 2, 3 or 4 of Xaa3, Xaa5, Xaa6 and Xaa7a is alpha N-methylated or wherein 1, 2, 3 or 4 of Xaa3, Xaa5, Xaa6 and Xaa7b is alpha N-methylated. The linker comprises an albumin-binding group.

  本发明提供了一种化合物，它由黑色素皮质素 1 受体（MC1R）靶向肽（MC1RTP）、放射性标记基团和连接 MC1RTP 与放射性标记基团的连接体组成。MC1RTP 是线性或环化的，由式 I 或式 II 的序列组成：Xaa1-Xaa2a-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7a (I) 或 Xaa1-Xaa2b-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7b (II)。Xaa1 是 L-/D-Nle、L-/D-Nle、L-/D-Ala、L-/D-Leu、L-/D-Ile、D-Ile、L-/D-Cys、L-/D-Met、L-/D-Phe、L-/D-Trp、L-/D-Val、L-/D-Nal、L-/D-2-Nal、Gly、L-/D-α-氨基丁酸、L-/D-正缬氨酸或 L-/D-单亮氨酸。Xaa2a 和 Xaa7b 是 L-/D-Cys、L-/D-Asp、L-/D-Glu、L-/D-2-Aad、L-/D-3-Aad、L-/D-Pra、L-/D-Hpg 或 L-/D-Bpg。Xaa2b 和 Xaa7a 是 L-/D-Cys、L-/D-Lys、L-/D-Orn、L-/D-Dab、L-/D-Dap、L-/D-Lys(N3)、L-/D-Orn(N3)、L-/D-Dab(N3)、L-/D-Dap(N3)、L-/D-2-(5′-叠氮戊基)丙氨酸或 L-/D-2-(6′-叠氮己基)丙氨酸。Xaa3 是 L-/D-His、Pro、β-(1,2,3-三唑-4-基)-L-丙氨酸、β-(1,2,3-三唑-4-基)-D-丙氨酸、1,2,4-三唑-3-丙氨酸或 1,2,4-三唑-3-D-丙氨酸。Xaa4 是 L-/D-Phe、L-/D-2-Nal、L-/D-Phe(4-F)、L-/D-Phe(4-Cl)、L-/D-Phe(4-Br)、L-/D-Phe(4-I)、L-/D-Phe(4-NH2)或 L-/D-Phe(4-NO2)。Xaa5 是 L-/D-Arg、L-/D-hArg）、Leu、L-/D-Agb 或 L-/D-Agp。Xaa6 是 L-/D-Trp、L-/D-Phe、L-/D-Trp(5-Br)、L-/D-Trp(5-OCH3)、L-/D-Trp(6-F)、L-/D-Trp(5-OH) 或 L-/D-Trp(CHO)。MC1RTP的一个或多个氨基酸残基为α-N-甲基化，其中Xaa3、Xaa5、Xaa6和Xaa7a中的1、2、3或4个氨基酸残基为α-N-甲基化，或者Xaa3、Xaa5、Xaa6和Xaa7b中的1、2、3或4个氨基酸残基为α-N-甲基化。连接体包括白蛋白结合基团。