4-azidobutanoic anhydride | 947386-28-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-azidobutanoic anhydride
• 英文别名: 4-Azidobutanoyl 4-azidobutanoate；4-azidobutanoyl 4-azidobutanoate
• CAS: 947386-28-9
• 化学式: C₈H₁₂N₆O₃
• 分子量: 240.222
• InChiKey: HBZGORWJDCYGEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-azidobutanoic anhydride 、 辅酶 A 在 盐酸 作用下， 以 水 、 乙腈 为溶剂， 生成 4-azidobutanoyl CoA
  参考文献：
  名称：

  Labeling Lysine Acetyltransferase Substrates with Engineered Enzymes and Functionalized Cofactor Surrogates

  摘要：

  Elucidating biological and pathological functions of protein lysine acetyltransferases (KATs) greatly depends on the knowledge of the dynamic and, spatial localization of their enzymatic targets in the cellular proteome. We report the design and application of chemical probes for facile labeling and detection of substrates of the three major human KAT enzymes. In this approach, we create engineered KATs in junction with synthetic Ac-CoA surrogates to effectively label KAT, substrates even in the presence of competitive nascent cofactor acetyl-CoA. The functionalized and transferable acyl moiety of the Ac-CoA analogs further allowed the labeled substrates to be probed with alkynyl or azido-tagged fluorescent reporters by the copper-catalyzed azide-alkyne cycloaddition. The synthetic cofactors, in combination with either native or rationally engineered KAT enzymes, provide a versatile chemical biology strategy to label and profile cellular targets of KATs at the proteomic level.

  DOI：

  10.1021/ja311636b
• 作为产物：
  描述：

  4-叠氮丁酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 4-azidobutanoic anhydride
  参考文献：
  名称：

  光不稳定接头：利用不稳定键化学来控制水凝胶降解和蛋白质释放的模式和速率

  摘要：

  光不稳定部分已用于从肽合成和受控蛋白质活化到可调和动态材料的应用。基于硝基苄基 (NB) 的接头的光致变色特性很容易调整以响应细胞相容性光剂量，并广泛用于细胞培养和其他微生物学应用。虽然被广泛使用，但关于微环境，特别是有限的水环境（例如，水凝胶）如何影响 NB 部分的裂解模式和速率，导致对系统特性控制的不可预测的限制（例如，快速水解或缓慢水解）知之甚少。光解）。为了应对这些挑战，我们合成并表征了含有不同不稳定键（即酯、酰胺、碳酸酯、或氨基甲酸酯）在逐步生长的水凝胶中充当不稳定的交联。我们观察到 NB 酯键表现出显着的光解和水解速率，而重要的是，NB 氨基甲酸酯键在水凝胶微环境中具有优异的光响应性和抗水解性。利用光解和水解降解的这种协同作用和正交性，我们设计了装载不同货物（例如，具有不同荧光团的模型蛋白）的同心圆柱水凝胶，分别用于组合或顺序释放。总体而言，这项工作为调节 NB 接头的降解性提

  DOI：

  10.1021/jacs.9b11564

文献信息

• [EN] SELECTIN OR GALECTIN ANTAGONISTS FOR TREATING CYTOKINE RELEASE SYNDROME AND CRS-INDUCED NEUROTOXICITY<br/>[FR] ANTAGONISTES DE LA SÉLECTINE OU DE LA GALECTINE POUR LE TRAITEMENT DU SYNDROME DE LIBÉRATION DE LA CYTOKINE ET DE LA NEUROTOXICITÉ INDUITE PAR LE CRS
  申请人：MAGNANI JOHN L

  公开号：WO2020150263A1

  公开（公告）日：2020-07-23

  Methods and compounds for the treatment and/or prevention of CRS and/or CRS-induced neurotoxicities using at least one selectin antagonist are disclosed. The disclosed methods and compounds use at least one of the disclosed antagonists to target and reduce cytokine expression and/or endothelial activation to treat and/or prevent CRS and/or CRS-related conditions such as CRS-induced neurotoxicities.

  使用至少一种选择素拮抗剂治疗和/或预防CRS和/或CRS诱导的神经毒性的方法和化合物被披露。披露的方法和化合物使用至少一种披露的拮抗剂来靶向和减少细胞因子表达和/或内皮活化，以治疗和/或预防CRS和/或CRS相关症状，如CRS诱导的神经毒性。
• [EN] GALACTOSE-LINKED MULTIMERIC GLYCOMIMETIC INHIBITORS OF E-SELECTINS, GALECTIN-3, AND/OR CXCR4 CHEMOKINE RECEPTORS<br/>[FR] INHIBITEURS GLYCOMIMÉTIQUES MULTIMÈRES LIÉS AU GALACTOSE DE SÉLECTINES E, DE GALECTINE-3 ET/OU DE RÉCEPTEURS DE CHIMIOKINE CXCR4
  申请人：GLYCOMIMETICS INC

  公开号：WO2020219417A1

  公开（公告）日：2020-10-29

  Compounds, compositions, and methods for treating and/or preventing at least one disease, disorder, and/or condition associated with E-selectin, galectin-3, and/or CXCR4 chemokine receptor activity are disclosed herein. For example, multimeric glycomimetic inhibitors ofE-selectins, galectin-3, and/or CXCR4 chemokine receptors and their use for treating and/or preventing inflammatory diseases, fibrosis, and cancers are disclosed. Formula (I).

  本文揭示了用于治疗和/或预防与E-选择素、galectin-3和/或CXCR4趋化因子受体活性相关的至少一种疾病、紊乱和/或状况的化合物、组合物和方法。例如，本文揭示了用于治疗和/或预防炎症性疾病、纤维化和癌症的E-选择素、galectin-3和/或CXCR4趋化因子受体的多聚糖类似物抑制剂及其用途。公式（I）。
• [EN] MOLECULAR LOGIC GATES FOR CONTROLLED MATERIAL DEGRADATION<br/>[FR] GRILLES LOGIQUES MOLÉCULAIRES POUR LA DÉGRADATION CONTRÔLÉE DE MATÉRIAU
  申请人：UNIV WASHINGTON

  公开号：WO2018057941A1

  公开（公告）日：2018-03-29

  The present disclosure features, inter alia, a cyclic multifunctional linker, including at least two cleavable moieties; at least two connecting chains connected to the at least two cleavable moieties to provide a cyclic structure; and at least two linking groups, each linking group being bonded at one end to a connecting chain and being located between two cleavable moieties, and each linking group having a second end configured to bond to crosslinkable moieties. In the cyclic multifunctional linker, each connecting chain has at least two ends, and at least two of the connecting chains are each connected at each end to a cleavable moiety.

  本公开涵盖了一个循环多功能连接物，包括至少两个可切断的基团；至少两个连接链连接到至少两个可切断的基团以提供一个循环结构；以及至少两个连接基团，每个连接基团在一端连接到一个连接链，并位于两个可切断的基团之间，每个连接基团具有第二端配置为与可交联基团结合。在循环多功能连接物中，每个连接链具有至少两个端点，并且至少两个连接链中的每一个端点都连接到一个可切断的基团。
• Dendron-decorated cyanine dyes for optical limiting applications in the range of telecommunication wavelengths
  作者：Pierre-Antoine Bouit、Robert Westlund、Patrick Feneyrou、Olivier Maury、Michael Malkoch、Eva Malmström、Chantal Andraud

  DOI：10.1039/b822485d

  日期：——

  Cyanine dyes decorated with 2,2-bis(methylol)propionic acid (bis-MPA) based dendrons up to third generation were synthesized. Dendrons were attached to the chromophore using a “click chemistry” reaction. Photophysical characterizations of these dyes show intense absorption and emission in the near-infrared (NIR), while nonlinear transmission experiments of the dendron-decorated chromophores indicate that properties in the IR of the parent dyes are conserved. This synthetic approach is a crucial preliminary step towards the preparation of solid functional materials for optical limiting (OL) applications in the IR.

  我们合成了以 2,2-双（甲醇）丙酸（bis-MPA）为基础的树枝状化合物装饰的第三代青色染料。树枝通过 "点击化学 "反应连接到发色团上。这些染料的光物理特性显示出在近红外（NIR）有强烈的吸收和发射，而树枝状装饰发色团的非线性透射实验表明，母体染料在红外的特性保持不变。这种合成方法是制备用于红外光限（OL）应用的固体功能材料的关键性初步步骤。
• Photoreversible Patterning of Biomolecules within Click-Based Hydrogels
  作者：Cole A. DeForest、Kristi S. Anseth

  DOI：10.1002/anie.201106463

  日期：2012.2.20

  Lighting the way: Biochemical cues have been reversibly patterned into hydrogels with full spatiotemporal control by using two photochemical reactions. The hydrogel is conjugated with a peptide by a thiol‐ene photoaddition reaction that is initiated by visible light. Subsequent, selective photocleavage of an o‐nitrobenzyl ether with UV light enables dynamic presentation of the peptide to cells with

  照亮道路：通过使用两种光化学反应，生化线索已可逆地图案化为具有完全时空控制的水凝胶。水凝胶通过可见光引发的硫醇-烯光加成反应与肽结合。随后，用紫外光选择性光裂解邻硝基苄基醚，可以在​​三个维度上将肽动态呈递给细胞。