4-(octyloxy)aniline hydrochloride | 30402-00-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(octyloxy)aniline hydrochloride
• 英文别名: 4-Octyloxy aniline hydrochloride；4-octoxyaniline;hydrochloride
• CAS: 30402-00-7
• 化学式: C₁₄H₂₃NO*ClH
• 分子量: 257.804
• InChiKey: LQTZHJWCIIFJRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.43
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(octyloxy)aniline hydrochloride 在 盐酸 、 potassium carbonate 、 sodium nitrite 作用下， 以 水 、 丙酮 、 乙腈 为溶剂， 反应 100.0h， 生成 N,N-tris-[2-(2-methoxyethoxy)ethyl]-[4-(4'-octyloxyphenyldiazenyl)phenoxyethyl]ammonium bromide
  参考文献：
  名称：

  JP2015/7026

  摘要：

  公开号：
• 作为产物：
  描述：

  对乙酰氨基酚 在 盐酸 、 potassium carbonate 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 反应 38.0h， 生成 4-(octyloxy)aniline hydrochloride
  参考文献：
  名称：

  光可液化离子晶体：具有功能多样性的光子储能材料的相交叉方法

  摘要：

  偶氮苯衍生物的离子晶体（IC）在紫外线照射下显示出光诱导的IC离子液体（IL）相变（光液化），并且所得的顺式偶氮苯ILs通过可见光可逆地光结晶。IC的光液化在环境温度下伴随着离子电导率的显着增加。光液化还使偶氮苯IC作为光子储能材料具有更大的意义。顺式-IL显示出热诱导的结晶至反式-IC相。这种转变伴随着放热峰，总ΔH为97.1 kJ mol -1，几乎是顺式偶氮苯生色团中存储的构象能量的两倍。因此，光敏性IL和自组装的集成推动了太阳能热电池的极限。

  DOI：

  10.1002/anie.201410184

文献信息

• [EN] PROCESS FOR THE SYNTHESIS OF COMPOUNDS WHICH ABSORB ULTRAVIOLET RADIATION IN FLOW CONDITIONS AND FORMULATIONS COMPRISING SAME<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE COMPOSÉS QUI ABSORBENT LE RAYONNEMENT ULTRAVIOLET DANS DES CONDITIONS D'ÉCOULEMENT ET FORMULATIONS LES COMPRENANT
  申请人：ELKIMIA INC

  公开号：WO2021168582A1

  公开（公告）日：2021-09-02

  The present invention generally relates to a chemical process under flow conditions for manufacturing compounds which absorb ultraviolet (UV) radiation and protect biological materials as well as non-biological materials from damaging exposure to UV radiation. The present invention further includes formulations and compositions comprising such compounds for use in absorbing UV radiation, as well as methods for protecting biological materials as well as non-biological materials from damaging exposure to UV radiation.

  本发明通常涉及一种在流动条件下的化学过程，用于制造吸收紫外线（UV）辐射并保护生物材料和非生物材料免受紫外线辐射破坏的化合物。本发明还包括含有这种化合物的配方和组合物，用于吸收紫外线辐射，以及保护生物材料和非生物材料免受紫外线辐射破坏的方法。
• Comparative structure-activity relationships of antifolate triazines inhibiting murine tumor cells sensitive and resistant to methotrexate
  作者：Cynthia Dias Selassie、Corwin Hansch、Tasneem A. Khwaja、Cecilia B. Dias、Stephanie Pentecost

  DOI：10.1021/jm00369a019

  日期：1984.3

  The inhibitory effect of 108 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines on murine L5178Y tumor cells, resistant and sensitive to methotrexate (MTX), has been studied. From the pI50 values, quantitative structure-activity relationships have been formulated which show that the lipophilic triazines are much more inhibitory against resistant cells than methotrexate or hydrophilic triazines. The results are compared with the behavior of other antifolate drugs that have been used in chemotherapy, as well as with eight antitumor drugs that are not antifolates. The acquired resistance of these cells toward hydrophilic antifolates may be attributed to the combined effect of an impaired active-transport system, a change in the conformation of dihydrofolate reductase in the resistant cells, and an amplified production of dihydrofolate reductase in the resistant cells.
• Galyametdinov, Yu. G.; Ivanova, G. I.; Ovchinnikov, I. V., Journal of general chemistry of the USSR, 1991, vol. 61, # 1.2, p. 212 - 215
  作者：Galyametdinov, Yu. G.、Ivanova, G. I.、Ovchinnikov, I. V.

  DOI：——

  日期：——
• Liquid crystalline N-aryl-β-aminovinyl ketones and their complexes with lanthanides
  作者：O. A. Turanova、Yu. G. Galyametdinov

  DOI：10.1134/s1070363206070152

  日期：2006.7

  Liquid crystalline lanthanide complexes with N-aryl-substituted beta-aminovinyl ketones were synthesized for the first time. The complexes give rise to smectic A mesophase and are stable only in the solid state; in going to solution, they dissociate with formation of the initial ligand.
• US4183958A
  申请人：——

  公开号：US4183958A

  公开（公告）日：1980-01-15