2-[甲基-[3-苯基-3-[4-(三氟甲基)苯氧基]丙基]氨基]乙酸 | 372198-80-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2-[甲基-[3-苯基-3-[4-(三氟甲基)苯氧基]丙基]氨基]乙酸
• 英文名称: Org24598
• 英文别名: N-methyl-N-[3-[(4-trifluoromethyl)phenoxy]-3-phenyl-propyl]glycine；Glycine, N-methyl-N-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-；2-[methyl-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino]acetic acid
• CAS: 372198-80-6
• 化学式: C₁₉H₂₀F₃NO₃
• 分子量: 367.368
• InChiKey: KZWQAWBTWNPFPW-UHFFFAOYSA-N

物化性质

• 沸点：
  483.7±45.0 °C(Predicted)
• 密度：
  1.254±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  氟西汀 在 lithium hydroxide 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-[甲基-[3-苯基-3-[4-(三氟甲基)苯氧基]丙基]氨基]乙酸
  参考文献：
  名称：

  Discovery and SAR of Org 24598—A Selective Glycine Uptake Inhibitor

  摘要：

  The discovery of Org 24598, one of the first potent and selective inhibitors of the glycine transporter is discussed. In vitro structure-activity relationships (SARs) data for interaction of a ligand with this system is discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00355-9

文献信息

• Compositions for enhancing memory and methods therefor
  申请人：Baudry Michel

  公开号：US20060063707A1

  公开（公告）日：2006-03-23

  Compositions for enhancing memory of a subject comprising a combination of a positive modulator of an AMPA receptor and a positive modulator of an NMDA receptor are provided, wherein each modulator of the combination is present at a subtherapeutic dose for effecting memory enhancement. Methods for using such compositions in the treatment of cognitive impairment associated with aging, age-related diseases, and CNS disorders, for example, are provided. New fusion molecules are also provided that combine the positive modulator functionalities into one molecule.

  提供了用于增强主体记忆的组合物，包括AMPA受体的正调节剂和NMDA受体的正调节剂，其中组合物中的每种调节剂均以次治疗剂量存在，以实现记忆增强效果。提供了在治疗与衰老、与年龄相关的疾病和中枢神经系统疾病相关的认知障碍中使用这种组合物的方法。还提供了将正调节剂功能结合到一个分子中的新融合分子。
• PSYCHO-PHARMACEUTICALS
  申请人：University College Dublin National University Of Ireland, Dublin

  公开号：EP2288345B1

  公开（公告）日：2015-06-10
• [EN] COMPOSITIONS FOR ENHANCING MEMORY AND METHODS THEREFOR<br/>[FR] COMPOSITIONS POUR RENFORCER LA MÉMOIRE ET PROCÉDÉS IDOINES
  申请人：LIFELIKE BIOMATIC INC

  公开号：WO2006034196A1

  公开（公告）日：2006-03-30

  Compositions for enhancing memory of a subject comprising a combination of a positive modulator of an AMPA receptor and a positive modulator of an NMDA receptor are provided, wherein each modulator of the combination is present at a subtherapeutic dose for effecting memory enhancement. Methods for using such compositions in the treatment of cognitive impairment associated with aging, age-related diseases, and CNS disorders, for example, are provided. New fusion molecules are also provided that combine the positive modulator functionalities into one molecule.
• [EN] PSYCHO-PHARMACEUTICALS<br/>[FR] PRODUITS PSYCHO-PHARMACEUTIQUES
  申请人：UNIV DUBLIN

  公开号：WO2009128058A1

  公开（公告）日：2009-10-22

  The invention provides a compound for use in the treatment of symptoms associated with psychosis, schizophrenia, a cognitive impairment disorder, a mood disorder, a nervous system disorder and/or a behavioral disorder. The compound has the formula ? and is administered to a subject in need thereof in an effective amount. The compound Meparfynol (3-methylpent-l-yn-3-ol) has been found to be effective.
• [EN] COMPOSITIONS TARGETING CB1 RECEPTOR FOR CONTROLLING FOOD INTAKE<br/>[FR] COMPOSITIONS CIBLANT LE RÉCEPTEUR CB1 POUR LA RÉGULATION DE LA PRISE ALIMENTAIRE
  申请人：INST NAT SANTE RECH MED

  公开号：WO2011067225A1

  公开（公告）日：2011-06-09

  The present invention relates to compositions and methods for controlling food intake exploiting the synergistic effects of CBl receptor agonists with GABA receptor or glutamate receptor agonists, respectively. More particularly, the present invention relates to compositions and method for reducing food intake and/or body weight in a mammal comprising administering to said mammal a pharmaceutically low amount of at least one CBl receptor agonist and an amount of at least one glutamate receptor agonist. The present invention also relates to compositions and method for elevating food intake and/or body weight in a mammal comprising administering to said mammal a pharmaceutically high amount of at least one CBl receptor agonist and an amount of at least one GABA receptor agonist.