[Cu(phen)(PPh3)2]NO3 | 33989-10-5

• 物质功能分类: 生物 - 生化试剂盒
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Cu(phen)(PPh3)2]NO3
• 英文别名: (1,10-phenanthroline)bis(triphenylphosphine)copper(I) nitrate；copper(1+);1,10-phenanthroline;triphenylphosphane;nitrate
• CAS: 33989-10-5
• 化学式: C₄₈H₃₈CuN₂P₂*NO₃
• 分子量: 830.342
• InChiKey: PXUBYFDFTVBCDA-UHFFFAOYSA-N

物化性质

• 熔点：
  202-204°C
• 稳定性/保质期：

  遵循规定使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  9.43
• 重原子数：
  57
• 可旋转键数：
  6
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.7
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 安全说明：
  S26,S36/37/39
• 危险类别码：
  R36/37/38
• 危险标志：
  GHS07
• 危险性描述：
  H315,H319,H335
• 危险性防范说明：
  P261,P305 + P351 + P338
• 储存条件：
  存于阴凉干燥处。

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product name : (1,10-Phenanthroline)bis(triphenylphosphine)copper(I) nitrate
dichloromethane adduct

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
According to Regulation (EC) No1272/2008
Skin irritation (Category 2)
Eye irritation (Category 2)
Specific target organ toxicity - single exposure (Category 3)
According to European Directive 67/548/EEC as amended.
Irritating to eyes, respiratory system and skin.
Label elements
Pictogram
Signal word Warning
Hazard statement(s)
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.
Precautionary statement(s)
P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Hazard symbol(s)
Xi Irritant
R-phrase(s)
R36/37/38 Irritating to eyes, respiratory system and skin.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
S36 Wear suitable protective clothing.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Formula : C48H38CuN3O3P2
Molecular Weight : 830,33 g/mol
CAS-No. EC-No. Index-No. Classification Concentration
(1,10-Phenanthroline)bis(triphenylphosphine)copper(I) nitrate dichloromethane adduct
33989-10-5 - - Skin Irrit. 2; Eye Irrit. 2; STOT -
SE 3; H315, H319, H335
Xi, R36/37/38
For the full text of the H-Statements mentioned in this Section, see Section 16.

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Section 4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire
protection.
Conditions for safe storage
Keep container tightly closed in a dry and well-ventilated place. Store in cool place.

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Personal protective equipment
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level
protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators
and components tested and approved under appropriate government standards such as NIOSH (US) or
CEN (EU).
Hand protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without
touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves
after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the
standard EN 374 derived from it.
Eye protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin and body protection
impervious clothing, The type of protective equipment must be selected according to the concentration
and amount of the dangerous substance at the specific workplace.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at
the end of workday.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Form solid
Safety data
pH no data available
Melting point 202 - 204 °C
Boiling point no data available
Flash point no data available
Ignition temperature no data available
Lower explosion limit no data available
Upper explosion limit no data available
Water solubility no data available

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Section 10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Conditions to avoid
no data available
Materials to avoid
Strong oxidizing agents
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx),
Oxides of phosphorus, Copper oxides

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Section 11. TOXICOLOGICAL INFORMATION
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional
waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent
and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
ADR/RID
Not dangerous goods
IMDG
Not dangerous goods
IATA
Not dangerous goods

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SECTION 15 - REGULATORY INFORMATION
N/A

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 双(三苯基膦)硝酸铜(I) 以 氯仿 为溶剂， 反应 0.5h， 以75%的产率得到[Cu(phen)(PPh3)2]NO3
  参考文献：
  名称：

  Methods and systems for preparing fused heterocyclic compounds using copper(I) catalysts

  摘要：

  一种铜(I)催化的合成苯并[b]杂环化合物的方法。该方案可用于合成多种2-芳基苯并[b]呋喃和吲哚，收率良好至优秀。此方法能容忍多种官能团，无需使用昂贵添加剂，并且不含钯。

  公开号：

  US07473786B1
• 作为试剂：
  描述：

  2,5-二溴对苯二胺 在 potassium phosphate 、 三叔丁基膦 、 [Cu(phen)(PPh3)2]NO3 、 palladium diacetate 、 caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 50.0h， 生成
  参考文献：
  名称：

  유기 화합물 및 이를 포함하는 유기 전계 발광 소자

  摘要：

  这项发明涉及将有机化合物及其包含在一个或多个有机层中以提高有机电致发光器件的发光效率、驱动电压、寿命等特性。

  公开号：

  KR20160078138A

文献信息

• Copper(I)–Phosphine Polypyridyl Complexes: Synthesis, Characterization, DNA/HSA Binding Study, and Antiproliferative Activity
  作者：Wilmer Villarreal、Legna Colina-Vegas、Gonzalo Visbal、Oscar Corona、Rodrigo S. Corrêa、Javier Ellena、Marcia Regina Cominetti、Alzir Azevedo Batista、Maribel Navarro

  DOI：10.1021/acs.inorgchem.6b02419

  日期：2017.4.3

  A series of copper(I)–phosphine polypyridyl complexes have been investigated as potential antitumor agents. The complexes [Cu(PPh3)2dpq]NO3 (2), [Cu(PPh3)2dppz]NO3 (3), [Cu(PPh3)2dppa]NO3 (4), and [Cu(PPh3)2dppme]NO3 (5) were synthesized by the reaction of [Cu(PPh3)2NO3] with the respective planar ligand under mild conditions. These copper complexes were fully characterized by elemental analysis, molar

  已经研究了一系列铜（I）-膦多吡啶基络合物作为潜在的抗肿瘤药。[Cu（PPh 3）2 dpq] NO 3（2），[Cu（PPh 3）2 dppz] NO 3（3），[Cu（PPh 3）2 dppa] NO 3（4）和[Cu通过[Cu（PPh 3）2 NO 3的反应合成了（PPh 3）2 dppme] NO 3（5）在温和的条件下用相应的平面配体]。这些铜络合物通过元素分析，摩尔电导率，FAB-MS和NMR，UV-vis和IR光谱进行了充分表征。这些铜（I）-膦基聚吡啶基络合物与DNA之间的相互作用已通过各种光谱技术和分析方法进行了研究，例如UV-vis滴定，热变性，圆二色性，粘度测量，凝胶电泳和竞争性荧光嵌入剂置换分析。我们的研究结果表明，这些铜（I）配合物以嵌入方式与DNA相互作用。此外，通过荧光研究确定了它们对人血清白蛋白的高蛋白结合亲和力。此外，所有复合物对几种肿瘤细胞系（人乳腺MC