2-(o-nitro)phenyl-tetrahydro-(2H)-1,3-oxazine | 124732-84-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(o-nitro)phenyl-tetrahydro-(2H)-1,3-oxazine
• 英文别名: 2-(2-Nitrophenyl)-1,3-oxazinane
• CAS: 124732-84-9
• 化学式: C₁₀H₁₂N₂O₃
• 分子量: 208.217
• InChiKey: HNJHUICSPWUAKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  67.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(o-nitro)phenyl-tetrahydro-(2H)-1,3-oxazine 生成 (E)-3-((2-nitrobenzylidene) amino)propan-1-ol
  参考文献：
  名称：

  Carbon transfer reactions with heterocycles - V. A facile synthesis of nifedipine and analogues

  摘要：

  DOI：

  10.1016/s0040-4020(01)89255-3
• 作为产物：
  描述：

  3-氨基-1-丙醇 、 邻硝基苯甲醛 以 甲醇 为溶剂， 以93%的产率得到2-(o-nitro)phenyl-tetrahydro-(2H)-1,3-oxazine
  参考文献：
  名称：

  Carbon transfer reactions with heterocycles - V. A facile synthesis of nifedipine and analogues

  摘要：

  DOI：

  10.1016/s0040-4020(01)89255-3

文献信息

• An expedient protocol of the Biginelli dihydropyrimidine synthesis using carbonyl equivalents
  作者：Kamaljit Singh、Jasbir Singh、Prasant K. Deb、Harjit Singh

  DOI：10.1016/s0040-4020(99)00760-7

  日期：1999.10

  A one - pot condensation of perhydro-1,3 heterocycles - aldehyde equivalents with ethyl acetoacetate and ureas provides a convenient synthesis of the title compounds with a variety of substituents at C-4. Yields are equivalent or significantly higher than the conventional methods.

  全氢-1,3杂环-醛当量与乙酰乙酸乙酯和脲的一锅缩合反应可方便地合成标题化合物，其在C-4处具有多个取代基。产率与常规方法相当或相当高。
• Modified Pictet–Spengler reaction. A highly diastereoselective approach to 1,2,3-trisubstituted-1,2,3,4-tetrahydro-β-carbolines using perhydro-1,3-heterocycles
  作者：Kamaljit Singh、Prasant K Deb、P Venugopalan

  DOI：10.1016/s0040-4020(01)00763-3

  日期：2001.9

  A flexible variant of the Pictet-Spengler reaction employing oxazinanes as synthetic equivalents of several carbonyl compounds has been developed. Using acid catalyzed one pot condensation of perhydro-1,3-heterocycles various 1,3-disubstituted and 1,2,3-trisubstituted-1,2,3,4-tetrahydro-beta -carbolines (THBCs) have been synthesized diastereoselectively. (C) 2001 Elsevier Science Ltd. All rights reserved.
• Efficient and versatile single pot approach to dipyrromethanes and bis(heterocyclyl)methanes
  作者：Kamaljit Singh、Sonia Behal、Maninder Singh Hundal

  DOI：10.1016/j.tet.2005.04.029

  日期：2005.7

  An efficient single pot route is presented involving the use of 0, N-perhydro 1,3-heterocycles as carbonyl equivalents for the synthesis of 5-substituted dipyrromethanes, 5,10-disubstituted tripyrranes and bis(heterocyclyl)methanes. (c) 2005 Elsevier Ltd. All rights reserved.
• SINGH, HARJIT;SINGH, KAMALJIT, TETRAHEDRON, 45,(1989) N2, C. 3967-3974
  作者：SINGH, HARJIT、SINGH, KAMALJIT

  DOI：——

  日期：——
• Carbon transfer reactions with heterocycles - V. A facile synthesis of nifedipine and analogues
  作者：Harjit Singh、Kamaljit Singh

  DOI：10.1016/s0040-4020(01)89255-3

  日期：1989.1