6,6'-dibromopenicillanicacid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6,6'-dibromopenicillanicacid
• 英文别名: (5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
• 化学式: C₈H₉Br₂NO₃S
• 分子量: 359.038
• InChiKey: YLGIIVBDSLVWDR-PUOGSPQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  82.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6,6'-dibromopenicillanicacid 生成 溴巴坦
  参考文献：
  名称：

  VON, DAEHNE, W.

  摘要：

  DOI：
• 作为产物：
  描述：

  6β-aminopenicillanic acid 在 硫酸 、 溴 、 sodium nitrite 作用下， 生成 6,6'-dibromopenicillanicacid
  参考文献：
  名称：

  Process Analytical Technology:  An Investment in Process Knowledge

  摘要：

  Process analytical technology (PAT) is fast becoming an integral part of many active pharmaceutical ingredient (API) production facilities. The incorporation of early PAT devices, such as pH probes for example, was shown to increase process efficiency and safety by acting on data in real time and by eliminating sampling. PAT applications, such as online redox, NIR, and sophisticated particle size analysis, increase (in real time) detailed knowledge of processes, thus affording increased robustness and greater straight-through processing (right-first-time) opportunities. Modern developments in analytical technologies provide chemical and analytical insights for all types of chemical reactions and process monitoring such as drying, distillations, crystallizations, hydrogenations, and others. This article will discuss two applications; each is very different from the other. The first application, redox monitoring, is a traditional PAT application used to monitor differences in the oxidation state of two reaction constituents. Our discussion will describe an oxidation/reduction (redox) application used to monitor the reduction of excess bromine with sodium bisulfite using an online probe. The second application is crystallization and granulation monitoring using a Lasentec Focused Beam Reflectance Measurement (FBRM) instrument for the optimization of a crystallization and granulation process in manufacturing (reference information is publicly available on this equipment; visit the Mettler-Toledo website at: http:// www.lasentec.com/method_of_measurement.html).

  DOI：

  10.1021/op0402127

文献信息

• CARROLL, RONNIE D.;VOLKMANN, ROBERT A.
  作者：CARROLL, RONNIE D.、VOLKMANN, ROBERT A.

  DOI：——

  日期：——
• MARTEL, ALAIN;DARIS, JEAN-PAUL;BACHAND, CAROL;MENARD, MARCEL, CAN. J. CHEM., 65,(1987) N 9, 2279-2281
  作者：MARTEL, ALAIN、DARIS, JEAN-PAUL、BACHAND, CAROL、MENARD, MARCEL

  DOI：——

  日期：——
• MARTEL, ALAIN;DARIS, JEAN-PAUL
  作者：MARTEL, ALAIN、DARIS, JEAN-PAUL

  DOI：——

  日期：——