2-[4-[(2-Fluorophenyl)methylideneamino]phenyl]sulfonylguanidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-[(2-Fluorophenyl)methylideneamino]phenyl]sulfonylguanidine
• 化学式: C₁₄H₁₃FN₄O₂S
• 分子量: 320.347
• InChiKey: AZNINNOQDAYIAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氟苯甲醛 、 磺胺脒 以 乙醇 为溶剂， 生成 2-[4-[(2-Fluorophenyl)methylideneamino]phenyl]sulfonylguanidine
  参考文献：
  名称：

  SYNTHETIC, STEREOCHEMICAL, AND BIOLOGICAL ASPECTS OF MANGANESE (II) COMPLEXES WITH UNSYMMETRICAL SULFUR CONTAINING BIDENTATE SCHIFF BASES

  摘要：

  The synthesis and characterization of tetracoordinated manganese (II) complexes of unsymmetrical sulpha drug azomethines having general formula ((MnLL2)-L-1,) are reported. The 1:1:1 reactions of hydrated manganese chloride with unsymmetrical monobasic bidentate azomethines resulted in the formation of coloured solids. The complexes have been characterized by elemental analysis, molecular weight determinations, magnetic measurements, IR, ESR, and UV spectral studies. The magnetic and spectral studies indicate tetrahedral geometry for the resulting complexes. The ligands along with their complexes have,been screened in vitro against a number of pathogenic fungal and bacterial strains. The antifertility activity of some representative ligands and their manganese complexes have been studied and important parameters like testicular biochemistry, sperm dynamics, and reproductive organ weights have been discussed. The studies indicate that the metal chelates are more potent than the parent ligands.

  DOI：

  10.1080/10426500490274664

文献信息

• SYNTHETIC, STEREOCHEMICAL, AND BIOLOGICAL ASPECTS OF MANGANESE (II) COMPLEXES WITH UNSYMMETRICAL SULFUR CONTAINING BIDENTATE SCHIFF BASES
  作者：R. V. Singh、S. C. Joshi、Rakhi Dwivedi

  DOI：10.1080/10426500490274664

  日期：2004.2.1

  The synthesis and characterization of tetracoordinated manganese (II) complexes of unsymmetrical sulpha drug azomethines having general formula ((MnLL2)-L-1,) are reported. The 1:1:1 reactions of hydrated manganese chloride with unsymmetrical monobasic bidentate azomethines resulted in the formation of coloured solids. The complexes have been characterized by elemental analysis, molecular weight determinations, magnetic measurements, IR, ESR, and UV spectral studies. The magnetic and spectral studies indicate tetrahedral geometry for the resulting complexes. The ligands along with their complexes have,been screened in vitro against a number of pathogenic fungal and bacterial strains. The antifertility activity of some representative ligands and their manganese complexes have been studied and important parameters like testicular biochemistry, sperm dynamics, and reproductive organ weights have been discussed. The studies indicate that the metal chelates are more potent than the parent ligands.