1-linolein-3-olein

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-linolein-3-olein
• 英文别名: rac 1-Oleoyl-3-linoleoylglycerol；[2-hydroxy-3-[(9Z,12Z)-octadeca-9,12-dienoyl]oxypropyl] (Z)-octadec-9-enoate
• 化学式: C₃₉H₇₀O₅
• 分子量: 618.982
• InChiKey: GREDRAMJRDQWEJ-LTEAFHAISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.7
• 重原子数：
  44
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  十八烷酰氯 、 1-linolein-3-olein 在 喹啉 作用下， 以 氯仿 为溶剂， 生成 α-Lineoyl-β-stearoyl-α'-olein
  参考文献：
  名称：

  Serebrennikova,G.A. et al., Journal of general chemistry of the USSR, 1962, vol. 32, p. 2174 - 2176

  摘要：

  DOI：
• 作为产物：
  描述：

  亚麻酰氯 、 1-monooleoyl glycerol 在 吡啶 作用下， 反应 24.0h， 生成 1-linolein-3-olein
  参考文献：
  名称：

  AGENTS FOR MAINTAINING UNDIFFERENTIATED STATE AND PROMOTING PROLIFERATION OF STEM CELLS

  摘要：

  本发明的目的是寻找一种新的物质，能够高效地促进干细胞的增殖，同时保持其未分化状态，并将该物质作为维持干细胞未分化状态的药剂或促进干细胞增殖的药剂提供。本发明的另一个目的是提供一种治疗伤口的药剂，该药剂对皮肤具有愈合作用，在皮肤再生医学或美容治疗领域中易得，且安全且价格便宜。本发明涉及一种维持干细胞未分化状态或促进干细胞增殖或治疗伤口的药剂，其包括以下通式（I）所表示的脂肪酸甘油酯之一或两种或更多种混合物作为活性成分：其中R1、R2和R3中至少有一个代表由具有16到22个碳原子的不饱和脂肪酸衍生的酰基，其他各自代表由饱和脂肪酸或氢原子衍生的酰基。

  公开号：

  US20170320809A1

文献信息

• SYSTEMS AND METHODS FOR MEASURING OBESITY USING METABOLOME ANALYSIS
  申请人：Human Longevity, Inc.

  公开号：US20190310269A1

  公开（公告）日：2019-10-10

  The disclosure relates to systems, software and methods for diagnosis or prognosis of subjects for obesity or a disease related thereto, including, classification and treatment of subjects who have been diagnosed with or deemed at risk of having obesity. The methods are based, in part, on the detection of the levels or activities of a plurality of metabolites or their derivatives, such as levels of amino acids, carbohydrates, lipids, nucleic acids, and/or cofactors, in the subject's biological sample, e.g., blood.
• MODIFIED AMINE LIPIDS
  申请人：Itellia Therapeutics, Inc.

  公开号：US20220119341A1

  公开（公告）日：2022-04-21

  The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
• [EN] SYSTEMS AND METHODS FOR MEASURING OBESITY USING METABOLOME ANALYSIS<br/>[FR] SYSTÈMES ET MÉTHODES DE MESURE D'OBÉSITÉ AU MOYEN D'UNE ANALYSE DE MÉTABOLOME
  申请人：HUMAN LONGEVITY INC

  公开号：WO2019195638A1

  公开（公告）日：2019-10-10

  The disclosure relates to systems, software and methods for diagnosis or prognosis of subjects for obesity or a disease related thereto, including, classification and treatment of subjects who have been diagnosed with or deemed at risk of having obesity. The methods are based, in part, on the detection of the levels or activities of a plurality of metabolites or their derivatives, such as levels of amino acids, carbohydrates, lipids, nucleic acids, and/or cofactors, in the subject's biological sample, e.g., blood.
• [EN] MODIFIED AMINE LIPIDS<br/>[FR] LIPIDES AMINÉS MODIFIÉS
  申请人：INTELLIA THERAPEUTICS INC

  公开号：WO2020118041A1

  公开（公告）日：2020-06-11

  The disclosure provides ionizable amine lipids and salts thereof (e.g., pharmaceutically acceptable salts thereof) useful for the delivery of biologically active agents, for example delivering biologically active agents to cells to prepare engineered cells. The ionizable amine lipids disclosed herein are useful as ionizable lipids in the formulation of lipid nanoparticle-based compositions.
• AGENTS FOR MAINTAINING UNDIFFERENTIATED STATE AND PROMOTING PROLIFERATION OF STEM CELLS
  申请人：NIPPON MENARD COSMETIC CO., LTD.

  公开号：US20170320809A1

  公开（公告）日：2017-11-09

  An object of the present invention is to find a novel substance that is capable of efficiently promoting the proliferation of stem cells while maintaining the undifferentiated state thereof and to provide the substance as an agent for maintaining the undifferentiated state of stem cells or an agent for promoting the proliferation of stem cells. Another object of the present invention is to provide an agent for treating a wound that has a wound healing effect on the skin and is readily available in the field of skin regenerative medicine or cosmetic treatment, and safe and inexpensive. The present invention relates to an agent for maintaining the undifferentiated state or promoting the proliferation of stem cells or an agent for treating a wound, comprising, as an active ingredient, one or a mixture of two or more of fatty acid glycerides represented by the following general formula (I): wherein at least one of R 1 , R 2 , and R 3 represents an acyl group derived from an unsaturated fatty acid having 16 to 22 carbon atoms and the others each represent an acyl group derived from a saturated fatty acid or a hydrogen atom.

  本发明的目的是寻找一种新的物质，能够高效地促进干细胞的增殖，同时保持其未分化状态，并将该物质作为维持干细胞未分化状态的药剂或促进干细胞增殖的药剂提供。本发明的另一个目的是提供一种治疗伤口的药剂，该药剂对皮肤具有愈合作用，在皮肤再生医学或美容治疗领域中易得，且安全且价格便宜。本发明涉及一种维持干细胞未分化状态或促进干细胞增殖或治疗伤口的药剂，其包括以下通式（I）所表示的脂肪酸甘油酯之一或两种或更多种混合物作为活性成分：其中R1、R2和R3中至少有一个代表由具有16到22个碳原子的不饱和脂肪酸衍生的酰基，其他各自代表由饱和脂肪酸或氢原子衍生的酰基。