(3aS,4S,6aR)-4-(4-Carboxymethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester | 817602-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: (3aS,4S,6aR)-4-(4-Carboxymethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester
• CAS: 817602-46-3
• 化学式: C₂₅H₃₆N₂O₈SSi
• 分子量: 552.721
• InChiKey: XDMWHAVLCUEWOX-IPJJNNNSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.64
• 重原子数：
  37.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  131.47
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  (3aS,4S,6aR)-4-(4-Carboxymethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester 在 4-二甲氨基吡啶 、 potassium fluoride 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 36.0h， 生成
  参考文献：
  名称：

  Protein Patterning Based on Electrochemical Activation of Bioinactive Surfaces with Hydroquinone-Caged Biotin

  摘要：

  We report a protein attachment and patterning method based on a hydroquinone-caged biotin surface that generates bioactive biotin by mild electrochemical perturbation. The electrochemical activation proceeds under the buffered aqueous environment at neutral pH. It also allows site-selective generation of bioactive biotin for the immobilization of target protein by using prepatterned electrode arrays.

  DOI：

  10.1021/ja0459330
• 作为产物：
  描述：

  (3aS,4S,6aR)-4-(4-tert-Butoxycarbonylmethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester 在 三氟乙酸 作用下， 以 氯仿 为溶剂， 反应 15.0h， 以100%的产率得到(3aS,4S,6aR)-4-(4-Carboxymethoxycarbonyl-butyl)-2-oxo-hexahydro-thieno[3,4-d]imidazole-1-carboxylic acid 4-(tert-butyl-dimethyl-silanyloxy)-phenyl ester
  参考文献：
  名称：

  Protein Patterning Based on Electrochemical Activation of Bioinactive Surfaces with Hydroquinone-Caged Biotin

  摘要：

  We report a protein attachment and patterning method based on a hydroquinone-caged biotin surface that generates bioactive biotin by mild electrochemical perturbation. The electrochemical activation proceeds under the buffered aqueous environment at neutral pH. It also allows site-selective generation of bioactive biotin for the immobilization of target protein by using prepatterned electrode arrays.

  DOI：

  10.1021/ja0459330