4-(甲氧基甲氧基)苯甲酸正丁酯 | 251640-53-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(甲氧基甲氧基)苯甲酸正丁酯
• 英文名称: n-butyl 4-(methoxymethoxy)benzoate
• 英文别名: Butyl 4-(methoxymethoxy)benzoate
• CAS: 251640-53-6
• 化学式: C₁₃H₁₈O₄
• 分子量: 238.284
• InChiKey: OIHUXCGMIZSHMZ-UHFFFAOYSA-N

物化性质

• 沸点：
  338.1±22.0 °C(Predicted)
• 密度：
  1.065±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(甲氧基甲氧基)苯甲酸正丁酯 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 3.0h， 以87%的产率得到4-(甲氧基甲基)苯甲酸
  参考文献：
  名称：

  Glucopyranoside Recognition by Polypyridine-Macrocyclic Receptors Possessing a Wide Cavity with a Flexible Linkage

  摘要：

  New polypyridine-macrocyclic receptors for glucopyranosides were designed and synthesized. The artificial receptors possess a terpyridine skeleton asa hydrogen-bonding site and a flexible polyoxyethylene chain as a bridge for the macrocyclic structure, in which the cavity of the receptors is large enough to incorporate pyranosides, The receptors showed high affinities for n-octyl beta-(D)-glucopyranoside, and selective binding of the receptors was observed between epimeric pyranosides. The results obtained in this paper demonstrated versatility of the terpyridine skeleton as a hydrogen-bonding site for saccharides.

  DOI：

  10.1021/jo9911138
• 作为产物：
  描述：

  尼泊金丁酯 、 氯甲基甲基醚 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以92%的产率得到4-(甲氧基甲氧基)苯甲酸正丁酯
  参考文献：
  名称：

  Glucopyranoside Recognition by Polypyridine-Macrocyclic Receptors Possessing a Wide Cavity with a Flexible Linkage

  摘要：

  New polypyridine-macrocyclic receptors for glucopyranosides were designed and synthesized. The artificial receptors possess a terpyridine skeleton asa hydrogen-bonding site and a flexible polyoxyethylene chain as a bridge for the macrocyclic structure, in which the cavity of the receptors is large enough to incorporate pyranosides, The receptors showed high affinities for n-octyl beta-(D)-glucopyranoside, and selective binding of the receptors was observed between epimeric pyranosides. The results obtained in this paper demonstrated versatility of the terpyridine skeleton as a hydrogen-bonding site for saccharides.

  DOI：

  10.1021/jo9911138

文献信息

• An asymmetric synthesis of l-[3-13C]phenylalanine and l-[3-13C]tyrosine from [13C]carbon monoxide
  作者：Kazuhiko Takatori、Mikiko Nishihara、Yukie Nishiyama、Masahiro Kajiwara

  DOI：10.1016/s0040-4020(98)00995-8

  日期：1998.12

  l-[3-13C]Phenylalanine and l-[3-13C]tyrosine were synthesized. [α-13C]Benzyl bromides were prepared from [13C]carbon monoxide via the palladium-catalyzed carboalkoxylation of aryl halides. The asymmetric carbon corresponding to the 2-position in phenylalanine was introduced by the diastereoselective alkylation of Dellaria's oxazinone with [α-13C]benzyl bromides. Finally, ethanolysis, deprotection,

  合成了1- [3- 13 C]苯丙氨酸和1- [3- 13 C]酪氨酸。[α- 13是从[制备C]苄基溴化物13 C]一氧化碳通过芳基卤化物的钯催化carboalkoxylation。对应于苯丙氨酸2-位的不对称碳是由Dellaria的恶嗪酮的非对映烷基化引入的[α- 13 C]苄基溴化物。最后，所得烷基化的恶嗪酮的乙醇解，脱保护，氢解和酸水解以高光学纯度得到1- [3- 13 C]苯丙氨酸和1- [3- 13 C]酪氨酸。
• An Efficient and Selective Deprotecting Method for Methoxymethyl Ethers
  作者：Yungui Peng、Changyun Ji、Yingchun Chen、Chengzhi Huang、Yaozhong Jiang

  DOI：10.1081/scc-200039382

  日期：2004.12.31

  Methoxymethyl ethers were selectively deprotected to the corresponding phenols in high yields by CBr4 and PPh3 in aprotic solvent (CICH2CH2Cl) under slightly thermal reaction conditions.