2',6'-diethyl-2-iodoacetanilide | 145143-46-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2',6'-diethyl-2-iodoacetanilide
• 英文别名: 2-iodo-N-<2,6-diethylphenyl>acetamide；Acetamide, N-(2,6-diethylphenyl)-2-iodo-；N-(2,6-diethylphenyl)-2-iodoacetamide
• CAS: 145143-46-0
• 化学式: C₁₂H₁₆INO
• 分子量: 317.17
• InChiKey: UBLXSCCLLZTJIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3-二氮杂萘 、 2',6'-diethyl-2-iodoacetanilide 以 丙酮 为溶剂， 反应 8.0h， 以80%的产率得到2-[N-(2,6-diethylphenyl)carbamoylmethyl]phtalazinium iodide
  参考文献：
  名称：

  Dumitraşcu, Florea; Mitan, Carmen Irena; Draghici, Constantin, Revue Roumaine de Chimie, 2002, vol. 47, # 3-4, p. 309 - 314

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-2,6-二乙基乙酰苯胺 在 sodium iodide 作用下， 以 丙酮 为溶剂， 反应 10.0h， 生成 2',6'-diethyl-2-iodoacetanilide
  参考文献：
  名称：

  Dumitraşcu, Florea; Mitan, Carmen Irena; Draghici, Constantin, Revue Roumaine de Chimie, 2002, vol. 47, # 3-4, p. 309 - 314

  摘要：

  DOI：

文献信息

• New substituted 2-(pyrazol-1-yl)-dialkylacetanilides with potential local anesthetic and antiarrhythmic action. Part II
  作者：Mircea Iovu、Christina Zalaru、Florea Dumitrascu、Constantin Draghici、Mircea Moraru、Elena Cristea

  DOI：10.1016/s0014-827x(02)00014-9

  日期：2003.4

  Nine substituted 2-(pyrazol-1-yl)-dialkylacetanilides were synthesized by N-alkylation of pyrazole and its derivatives with several 2-iodoacetanilides. The new compounds exhibited local anesthetic and antiarrhythmic actions. They have been characterized by elemental chemical analysis, UV-Vis, IR, 1H NMR, 13C NMR, SM spectra and pharmacology research.

  通过吡唑及其衍生物与几种2-碘乙酰苯胺的N-烷基化反应合成了九个取代的2-（吡唑-1-基）-二烷基乙酰苯胺。新化合物表现出局部麻醉和抗心律不齐的作用。它们已通过元素化学分析，UV-Vis，IR，1H NMR，13C NMR，SM光谱和药理研究进行了表征。
• Active heteromethylene compounds. 3. Synthesis of 4,4-difluoro-2-azetidinones from .alpha.-haloacetamides and Freon 22
  作者：John P. Chupp、David M. Hemmerly、John J. Freeman

  DOI：10.1021/jo00053a045

  日期：1993.1
• METHOD FOR DOUBLE STRAND SEQUENCING
  申请人：Oxford Nanopore Technologies PLC

  公开号：US20220389481A1

  公开（公告）日：2022-12-08

  Provided herein is a method of sequencing a target double stranded nucleic acid. The method comprises contacting the double stranded nucleic acid with a reagent as described herein to form a construct and sequencing the construct using a single-molecule sequencing technique as described herein. Associated products and kits are further provided.
• [EN] METHOD FOR DOUBLE STRAND SEQUENCING<br/>[FR] PROCÉDÉ DE SÉQUENÇAGE À DOUBLE BRIN
  申请人：OXFORD NANOPORE TECH LTD

  公开号：WO2021099801A1

  公开（公告）日：2021-05-27

  Provided herein is a method of sequencing a target double stranded nucleic acid. The method comprises contacting the double stranded nucleic acid with a reagent as described herein to form a construct and sequencing the construct using a single-molecule sequencing technique as described herein. Associated products and kits are further provided.
• [EN] METHOD OF CHARACTERISING A TARGET POLYPEPTIDE USING A NANOPORE<br/>[FR] PROCÉDÉ DE CARACTÉRISATION D'UN POLYPEPTIDE CIBLE À L'AIDE D'UN NANOPORE
  申请人：OXFORD NANOPORE TECH LTD

  公开号：WO2021111125A1

  公开（公告）日：2021-06-10

  Provided herein are methods of characterising a target polypeptide as it moves with respect to a nanopore. Also provided are related kits, systems and apparatuses for carrying out such methods.