Nonanamide, N-[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]methyl]-

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Nonanamide, N-[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]methyl]-
• 英文别名: N-[[4-[tert-butyl(dimethyl)silyl]oxy-3-methoxyphenyl]methyl]nonanamide
• 化学式: C₂₃H₄₁NO₃Si
• 分子量: 407.669
• InChiKey: ZZGHKDPDWQUUGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.45
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Nonanamide, N-[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]methyl]- 在 盐酸 、 正丁基锂 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 水 为溶剂， 反应 12.0h， 生成 N-methylnonivamide triflate
  参考文献：
  名称：

  An Improved Catalyst System for the Pd-Catalyzed Fluorination of (Hetero)Aryl Triflates

  摘要：

  The stable Pd(0) species [(1,5-cyclooctadiene)(L.Pd)(2)] (L = AdBrettPhos) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biologically active and heteroaryl phenols, challenging substrates for our previously reported catalyst system. Additionally, this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles.

  DOI：

  10.1021/ol402859k
• 作为产物：
  描述：

  香草壬酰胺 、 叔丁基二甲基氯硅烷 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以99%的产率得到Nonanamide, N-[[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methoxyphenyl]methyl]-
  参考文献：
  名称：

  An Improved Catalyst System for the Pd-Catalyzed Fluorination of (Hetero)Aryl Triflates

  摘要：

  The stable Pd(0) species [(1,5-cyclooctadiene)(L.Pd)(2)] (L = AdBrettPhos) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biologically active and heteroaryl phenols, challenging substrates for our previously reported catalyst system. Additionally, this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles.

  DOI：

  10.1021/ol402859k

文献信息

• An Improved Catalyst System for the Pd-Catalyzed Fluorination of (Hetero)Aryl Triflates
  作者：Hong Geun Lee、Phillip J. Milner、Stephen L. Buchwald

  DOI：10.1021/ol402859k

  日期：2013.11

  The stable Pd(0) species [(1,5-cyclooctadiene)(L.Pd)(2)] (L = AdBrettPhos) has been prepared and successfully evaluated as a precatalyst for the fluorination of aryl triflates derived from biologically active and heteroaryl phenols, challenging substrates for our previously reported catalyst system. Additionally, this precatalyst activates at room temperature under neutral conditions, generates 1,5-cyclooctadiene as the only byproduct, and leads to overall cleaner reaction profiles.