(E)-N-(2,6-dimethylphenyl)formamidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N-(2,6-dimethylphenyl)formamidine
• 英文别名: N'-(2,6-dimethylphenyl)methanimidamide
• 化学式: C₉H₁₂N₂
• 分子量: 148.208
• InChiKey: HGLSGOCZYXRXNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-N-(2,6-dimethylphenyl)formamidine 在 正丁基锂 作用下， 以 四氢呋喃 、 乙醚 、 正戊烷 为溶剂， 反应 16.0h， 生成 [(E)-N'-(2,6-dimethylphenyl)-N-(diisopropylphosphino)formamidine](THF)CrCl3
  参考文献：
  名称：

  [EN] PHOSPHINYL FORMAMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS
  [FR] COMPOSÉS PHOSPHINYL FORMAMIDINE, COMPLEXES MÉTALLIQUES, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES

  摘要：

  描述了N2-磷酰基甲酰胺化合物和N2-磷酰基甲酰胺金属盐配合物。还公开了制备N2-磷酰基甲酰胺化合物和N2-磷酰基甲酰胺金属盐配合物的方法。还公开了利用N2-磷酰基甲酰胺金属盐配合物的催化剂体系，以及利用N2-磷酰基胺化合物和N2-磷酰基胺金属盐配合物进行烯烃的寡聚和/或聚合的用途。

  公开号：

  WO2015094207A1
• 作为产物：
  描述：

  2,6-二甲基苯胺 在 碳酸氢铵 、 对甲苯磺酸 作用下， 以 甲醇 、 苯 为溶剂， 反应 24.0h， 生成 (E)-N-(2,6-dimethylphenyl)formamidine
  参考文献：
  名称：

  [EN] PHOSPHINYL FORMAMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS
  [FR] COMPOSÉS PHOSPHINYL FORMAMIDINE, COMPLEXES MÉTALLIQUES, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES

  摘要：

  描述了N2-磷酰基甲酰胺化合物和N2-磷酰基甲酰胺金属盐配合物。还公开了制备N2-磷酰基甲酰胺化合物和N2-磷酰基甲酰胺金属盐配合物的方法。还公开了利用N2-磷酰基甲酰胺金属盐配合物的催化剂体系，以及利用N2-磷酰基胺化合物和N2-磷酰基胺金属盐配合物进行烯烃的寡聚和/或聚合的用途。

  公开号：

  WO2015094207A1

文献信息

• HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
  申请人：Kozikowski Alan

  公开号：US20140128408A1

  公开（公告）日：2014-05-08

  Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

  本发明公开了组蛋白去乙酰化酶抑制剂（HDACIs）及其组成物。公开了治疗疾病和状况的方法，其中抑制HDAC提供了益处，如癌症、神经退行性疾病、周围神经病变、神经疾病、创伤性脑损伤、中风、高血压、疟疾、自身免疫疾病、自闭症、自闭症谱系障碍和炎症。
• Multinuclear Copper(I) and Silver(I) Amidinate Complexes: Synthesis, Luminescence, and CS₂ Insertion Reactivity
  作者：Andrew C. Lane、Matthew V. Vollmer、Charles H. Laber、Doris Y. Melgarejo、Gina M. Chiarella、John P. Fackler、Xinzheng Yang、Gary A. Baker、Justin R. Walensky

  DOI：10.1021/ic501694d

  日期：2014.11.3

  Dinuclear Cu(I) and Ag(I) complexes, Cu-2[(2,6-Me2C6H3N)(2)C(H)](2), 1, Ag2[(2,6-Me2C6H3N)(2)C(H)](2), 2, Cu-2[2,6-(i)Pr2C6H3N)(2)C(H)](2), 3, and Ag-2[(2,6-(i)Pr2C6H3N)(2)C(H)](2), 4, were synthesized from reactions of [Cu(NCCH3)4][PF6] with Na[(2,6-R2C6H3N)2C(H)] and AgO2CCH3 with [Et3NH][(2,6-R2C6H3N2C(H)], R = Me, (i)Pr. Carbon disulfide was observed to insert into the metal-nitrogen bonds of 1 to produce Cu-4[CS2(2,6-Me2C6H3NC(H)-NC6H3Me2)]4, 5, with a Cu4S8 core, which represents a rare transformation of dinuclear to tetranuclear species. Insertion is also observed with 2 and CS2, with the product likely being polymeric, 6. With the (i)Pr-derivatives, CS2 insertion was also observed, albeit at much slower rate, with 3 and 4 producing hexanuclear clusters, M-6[CS2(2,6-Me2C6H3NC(H)-NC6H3Me2)](6), M = Cu, 7; Ag, 8. Complexes 1 and 5 display green luminescence, a feature not shared by their Ag(I) analogs nor with 3. Notably, oxygen acts as a collisional quencher of the luminescence from 1 and 5 at a rate faster than most metal-based quenchometric O-2 sensors. For example, we find that complex 1 can be rapidly and reversibly quenched by oxygen, presenting a nearly 6-fold drop in intensity upon switching from nitrogen to an aerated atmosphere. The results here provide a platform from which further group 11 amidinate reactivity can be explored.
• PHOSPHINYL FORMAMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS
  申请人：Chevron Phillips Chemical Company LP

  公开号：EP3083646A1

  公开（公告）日：2016-10-26
• Phosphinyl Formamidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins
  申请人：Chevron Phillips Chemical Company LP

  公开号：US20160375431A1

  公开（公告）日：2016-12-29

  N 2 -phosphinyl formamidine compounds and N 2 -phosphinyl formamidine metal salt complexes are described. Methods for making N 2 -phosphinyl formamidine compounds and N 2 -phosphinyl formamidine metal salt complexes are also disclosed. Catalyst systems utilizing the N 2 -phosphinyl formamidine metal salt complexes are also disclosed along with the use of the N 2 -phosphinyl amidine compounds and N 2 -phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.
• US9962689B2
  申请人：——

  公开号：US9962689B2

  公开（公告）日：2018-05-08