3-MOM-HM | 5053-45-2

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: 3-MOM-HM
• 英文别名: 3-O-Methoxymethyl-dimorphinon；4,5α-epoxy-3-methoxymethoxy-17-methyl-morphinan-6-one；(4R,4aR,7aR,12bS)-9-(methoxymethoxy)-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one
• CAS: 5053-45-2
• 化学式: C₁₉H₂₃NO₄
• 分子量: 329.396
• InChiKey: FAIZQVBKZNFIIL-ATNYCFDYSA-N

物化性质

• 沸点：
  492.6±45.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-MOM-HM 在 溶剂黄146 作用下， 反应 40.0h， 生成 6-亚甲基二氢环氧吗啡
  参考文献：
  名称：

  Synthesis and Pharmacology of 6-Methylenedihydrodesoxymorphine¹

  摘要：

  DOI：

  10.1021/jm00319a001
• 作为产物：
  描述：

  氢吗啡酮 、 氯甲基甲基醚 生成 3-MOM-HM
  参考文献：
  名称：

  Synthesis and Pharmacology of 6-Methylenedihydrodesoxymorphine¹

  摘要：

  DOI：

  10.1021/jm00319a001

文献信息

• [EN] BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF<br/>[FR] CONJUGUÉS D'HYDROMORPHONE AVEC DE L'ACIDE BENZOÏQUE, DES DÉRIVÉS D'ACIDE BENZOÏQUE ET UN ACIDE HÉTÉROARYLCARBOXYLIQUE, PROMÉDICAMENTS, LEURS PROCÉDÉS DE FABRICATION ET LEURS UTILISATIONS
  申请人：KEMPHARM INC

  公开号：WO2013063204A1

  公开（公告）日：2013-05-02

  The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.

  目前描述的技术提供了含有芳基羧酸与羟吗啡（4,5-α-环氧-3-羟基-17-甲基吗啡-6-酮）化学共轭形成的新型前药/羟吗啡组合物的组合物。与未共轭的羟吗啡相比，本技术的羟吗啡前药具有减少副作用和滥用潜力的特点。本技术还提供了治疗患者的方法、药物配套工具和合成本技术共轭物的方法。
• BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF HYDROMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF
  申请人：KemPharm, Inc.

  公开号：US20130150395A1

  公开（公告）日：2013-06-13

  The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
• Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydromorphone, Prodrugs, Methods of Making and Use Thereof
  申请人：KemPharm, Inc.

  公开号：US20170143839A1

  公开（公告）日：2017-05-25

  The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
• US8816083B2
  申请人：——

  公开号：US8816083B2

  公开（公告）日：2014-08-26
• US9566343B2
  申请人：——

  公开号：US9566343B2

  公开（公告）日：2017-02-14